Bridge to Life: The Lifebridge B2T® extracorporeal life support system in an in vitro trial

Abstract

Extracorporeal life support systems (ECLS) have become common in cardiothoracic surgery, but are still “Terra Incognita” in other medical fields due to the fact that perfusion units are normally bound to cardiothoracic centres. The Lifebridge B2T^® is an ECLS that is meant to be used as an easy and fast-track extracorporeal cardiac support to provide short-term perfusion for the transport of a patient to a specialized centre. With the Lifebridge B2T^®, it is now possible to provide extracorporeal bypass for patients in hospitals without a perfusion unit. The Lifebridge B2T^® was tested on three calves to analyze the handling, performance and security of this system. The Lifebridge B2T^® safely can be used clinically and can provide full extracorporeal support for patients in cardiac or pulmonary failure. Flows up to 3.9 ± 0.2l/min were reached, with an inflow pressure of −103 ± 13mmHg, using a 21Fr. BioMedicus^® (Medtronic, Minneapolis, MN, USA) venous cannula. The “Plug and Play” philosophy, with semi-automatic priming, integrated check-list, a long battery time of over two hours and instinctively designed user interface, makes this device very interesting for units with high-risk interventions, such as catheterisation labs. If a system is necessary in an emergency unit, the Lifebridge can provide a high security level, even in centres not acquainted with cardiopulmonary bypass.

Keywords

cardiopulmonary bypass ECMO (extracorporeal membrane oxygenation)extracorporeal life support mechanical assist device

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References

1 Hill, JD, O’Brian, TG, Murray, JJ, et al. Prolonged extracorporeal oxygenation for acute post-traumatic respiratory failure(shock-lung syndrome). Use of the Bramson membrane lung. N Engl J Med 1972; 286(12): 629–634.

2 Zapol, WM, Snider, MT, Hill, JD, et al. Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized pospective study. JAMA 1979; 242(20): 2193–2196.

3 Vainer, J, van Ommen, V, Maessen, J, Geskes, G, Lamerichs, L, Waltenberger, J. Elective high-risk percutaneous coronary interventions supported by extracorporeal life support. Am J Cardiol 2007; 99(6): 771–773.

4 Perez, A, Butt, WW, Millar, KJ, et al. Long-distance transport of critically ill children on extracorporeal life support in Australia. Crit Care Resusc 2008; 10(1): 34.

5 Kolcz, J, Pietrzyk, J, Januszewska, K, Procelewska, M, Mroczek, T, Malec, E. Extracorporeal life support in severe propranolol and verapamil intoxication. J Intensive Care Med 2007; 22(6): 381–385.

6 Tsai, FC, Wang, YC, Huang, et al. Extracorporeal life support to terminate refractory ventricular tachycardia. Crit Care Med 2007; 35(7): 1673–1676.

7 Madershahian, N, Wittwer, T, Strauch, J, et al. Application of ECMO in multitrauma patients with ARDS as rescue therapy. J Card Surg 2007; 22(3): 180–184.

8 Potapov, EV, Merkle, F, Güttel, A, et al. Transcontinental transport of a patient with an AbioMed BVS 5000 BVAD. Ann Thoac Surg. 2004; 77(4): 1428–1430.

9 Ferrari, M, Wittman, G, Neumann, S, et al. Die perkutan implantierbare Herz-Lungen-Maschine erweitert die therapeutischen und diagnostischen Möglichkeiten bei therapiefraktärem Kreislaufstillstand. Intensivmedizin und Notfallmedizin 1998; 35: 56–61.

10.

10 Combes, A, Leprince, P, Luyt, CE, et al. Outcomes and long-term quality-of-life of patients supported by extracorporeal membrane oxygenation for refractory cardiogenic shock. Crit Care Med 2008; 36(5): 1404–1411.

11.

11 Segers, PA, Heida, JF, de Vries, I, Maas, C, Boogaart, AJ, Eilander, S. Clinical evaluation of nine hollow-fibre membrane oxygenators. Perfusion 2001; 16: 95–106.

12.

12 Brown, SM, Fennigkoh, L, Gerrits, R, Hietpas, M, Tritt, C. A model of venous return while utilizing vacuum assist during cardiopulmonary bypass. J Extra Corpor Technol 2003; 35(3): 224–229.

13.

13 Ni, YM, Leskosek, B, Shi, LP, et al. Optimization of venous tubing diameter for cardiopulmonary bypass. Eur J Cardiothorac Surg 2001; 20: 614–620.