Primary pulmonary synovial sarcoma is a very rare tumor, thus there is no consensus as to the most appropriate management. A 78-year-old man presented with nonspecific symptoms of weight loss and shortness of breath. Imaging confirmed a large right-sided mass and accompanying pleural effusion. Strong 18F-fluorodeoxyglucose uptake was found on positron-emission tomography. The preoperative work-up and intraoperative frozen section were inconclusive. Immunohistochemistry and molecular analysis confirmed the diagnosis of primary pulmonary monophasic synovial sarcoma.
DennisonSWepplerEGiacoppeG. Primary pulmonary synovial sarcoma: a case report and review of current diagnostic and therapeutic standards. Oncologist2004; 9: 339–342.
2.
JindalTDuttaRKumarAKumarRKumarNChoudharySK. Primary pulmonary synovial cell sarcoma: radiological findings and management. Asian Cardiovasc Thorac Ann2011; 19: 72–75.
3.
LisleJWEaryJFO'SullivanJConradEU. Risk assessment based on FDG-PET imaging in patients with synovial sarcoma. Clin Orthop Relat Res2009; 467: 1605–1611.
4.
WatzkaSSetinekUProschHMullerM. Primary synovial sarcoma of the lung as an incidental finding. Interact Cardiovasc Thorac Surg2009; 9: 1026–1028.
5.
LadanyiMAntonescuCRLeungDH. Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. Cancer Res2002; 62: 135–140.
6.
NilssonGSkyttingBXieY. The SYT-SSX1 variant of synovial sarcoma is associated with a high rate of tumor cell proliferation and poor clinical outcome. Cancer Res1999; 59: 3180–3184.
7.
Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: meta-analysis of individual data. Sarcoma Meta-Analysis Collaboration. Lancet1997; 350: 1647–1654.
8.
KawaiAWoodruffJHealeyJBrennanMAntonescuCLadanyiM. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med1998; 338: 153–160.
