Langerhans-cell histiocytosis is characterized by abnormal proliferation of Langerhans cells, and frequently associated with cigarette smoking. A 24-year-old man who underwent excisional biopsy of a pulmonary nodule and segmental rib resection was found to have the eosinophilic granuloma variation of Langerhans-cell histiocytosis.
GaensierEACarringtonCB. Open biopsy of chronic diffuse infiltrative lung disease: Clinical roentgenographic, and physiological correlations in 502 patients. Ann Thorac Surg1980; 30: 411–26
TravisWDBorokZRoumJHZhangJFeuersteinIFerransVJPulmonary Langerhans' cell granulomatosis (histiocytosis X): a clinicopathologic study of 48 cases. Am J Surg Pathol1993; 17: 971–86
4.
CasolaroMABernaudinJFSaltiniCFerransVJCrystalRG. Accumulation of Langerhans' cells on the epithelial surface of the lower respiratory tract in normal subjects in association with cigarette smoking. Am Rev Respir Dis1988; 137: 406–11
5.
SchönfeldNFrankWWenigSUhrmeisterPAllicaEPreusslerHClinical and radiologic features, lung function and therapeutic results in pulmonary histiocytosis X. Respiration1993; 60: 38–44
6.
GionaFCarusoRTestiAMMoletiMLMalagninoFMartelliMLangerhans' cell histiocytosis adults: a clinical and therapeutic analysis of 11 patients from a single institution. Cancer1997; 80: 1786–91
