On occasion of the 25th year of publication of Toxicologic Pathology, the Editor has asked for a report about recent progress in the area addressed by an article entitled “Olefinic Hydrocarbons: A First Risk Estimate,” one of the top 10 most frequently cited papers of the journal (3). Because general issues of risk assessment have very recently been addressed in this journal (6), I will focus on new specific aspects of ethene carcinogenicity.
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