Neuro Omics: Translational Neuropathology Applications of Spatial Technologies From Nonclinical Models to Human Disease

Abstract

The basis for current and future neurologic disease research and therapeutic discovery and development is rooted in the understanding of genetic, transcriptional, and molecular expression profiles of cells and their spatial interplays in anatomical context. Neuro omics aim to analyze all possible molecular and morphological types within the nervous system using specific methods such as genomics, transcriptomics, proteomics, metabolomics, and pathomics (ie, radiology and histology). In this scientific session of the Society of Toxicologic Pathology’s 44th Annual Symposium, speakers with diverse experience in drug discovery and nonclinical development presented scientific principles and practical applications of some of the emerging omics technologies as applied to the pursuit of target discovery, preclinical safety, and mechanistic investigations of novel human therapeutics. Spanning both human biology, such as Alzheimer disease, and nonclinical models, session speakers also shared their insights on the promise as well as pitfalls of the omics workflow in nonclinical drug development laboratories.