We describe the preparation of cellulose nanofibrous material directly from cellulose solution via electrospinning. The resulting nanofiber is composed of pure cellulose. The spinning procedure can be performed under ambient conditions at room temperature without post-spun treatment. By mixing drugs with the pre-spun cellulose solution, followed by electrospinning, the drug-loaded nanofiber was prepared and the releasing properties were examined with respect to biomedical applications.
Doshi, J., and Reneker, D.H., Electrospinning Process and Applications of Electrospun Fibers, J. Electrost., 35, 151-160 (1995).
2.
Fong, H., and Reneker, D.H., Electrospinning and the Formation of Nanofibers, in "Structure Formation in Polymeric Fibers", Salem, D. R. (ed.), Hanser Gardner, Munich, 2001, pp. 225-246.
Formhals, A., "Electrical Spinning of Fibers from Solutions", U.S. Patent 2123992, 1938.
5.
Formhals, A., "Electrical Spinning of Fibers such as Those Produced from Cellulose Acetate", US Patent, 2116942, 1938.
6.
Ward, K.J., Occurrence of Cellulose, in "Cellulose and Cellulose Derivatives ", Ott, E. (ed.), Interscienc, New York, 1943, pp. 7-25.
7.
Ohkawa, K., Cha, D., Kim, H., Nishida, A., and Yamamoto, H., Electrospinning of Chitosan, Macromol. Rapid Commun., 25, 1600-1605 (2004).
8.
Kulpinski, P. , Cellulose Nanofibers Prepared by the N-methylmorpholine-N-oxide Method, J. Appl. Polym. Sci., 98, 1855- 1859 ( 2005).
9.
Kim, C.-W. , Frey, M.W., Marquez, M., and Joo, Y.L., Preparation of Submicron-scale Electrospun Cellulose Fibers via Direct Dissolution, J. Polym. Sci. B: Polym. Phys., 43, 1673- 1683 (2005).
10.
Kim, C.-W. , Kim, D.-S., Kang, S.-Y., Marquez, M., and Joo, Y.L., Structural Studies of Electrospun Cellulose Nanofibers, Polymer, 47, 5097-5107 (2006 ).
11.
Frey, M.W., and Joo, Y.L., "Cellulose Solution in Solvent and Electrospinning Thereof", U.S. Patent Application 834041, 2004; U.S. Patent 247236, 2005.
12.
Kang, Y.S., Kim, H.Y., Ryu, Y.J., and Lee, D.R., Manufacturing the Cellulose Web by using Electro-spinning and in vitro Behaviour of Oxidized Cellulose Web, J. Korean Fiber Soc., 39, 14-20 (2002).
13.
Son, W.K. , Youk, J.H., and Park, W.H., Preparation of Ultrafine Oxidized Cellulose Mats via Electrospinning, Biomacromolecules, 5, 197-201 (2004).
14.
Ohkawa, K., Minato, K.-I., Kumagai, G., Hayashi, S., and Yamamoto, H., Chitosan Nanofiber, Biomacromolecules, 7, 3291-3294 ( 2006).
15.
Hasegawa, M. , Isogai, A., Onabe, F., and Usuda, M., Dissolving States of Cellulose and Chitosan in Trifluoroacetic Acid, J. Appl. Polym. Sci., 45, 1857-1863 (1992).
Ohkawa, K., Kim, H., Lee, K., and Yamamoto, H., Electrospun Non-woven Fabrics of poly(ε-caprolactone) and their Biodegradation by Pure Cultures of Soil Filamentous Fungi, Macromol. Symp. , 216, 301-306 (2004).
18.
Goldberg, M. , Langer, R., and Jia, X., Nanostructured Materials for Applications in Drug Delivery and Tissue Engineering, J. Biomater. Sci. Polym. Ed., 18, 241-268 (2007).
19.
Takagi, H., and Asano, A., Characterization of "Green" Composites Reinforced by Cellulose Nanofibers , Key Eng. Mater., 334-335, 389-392 (2007).
20.
Ma, Z., Kotaki, M., and Ramakrishna, S., Electrospun Cellulose Nanofiber as Affinity Membrane, J. Membrane Sci., 265, 115-123 (2005).
21.
Huang, Z.-M. , Zhang, Y.Z., Kotaki, M., and Ramakrishna , S., A Review on Polymer Nanofibers by Electrospinning and their Applications in Nanocomposites, Compos . Sci. Technol., 63, 2223-2253 (2003 ).