This paper describes the control and operational management process of plant-wide production processes and analyzes the relationship between the control system actions and the multiple global production indices that characterize quality, yield, costs, and consumptions etc. The existing research results in control and optimization are reviewed. From the angles of mathematical models-based, data-based and their combinations, the state-of-art of control and optimization is summarized. This is followed by the analysis on the challenging issues on the optimal control for plant-wide production processes in terms of process control, operational optimization and the realization of the control systems.
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