Practicing clinicians come across uses of pharmacologic agents that may not always be listed in the usual references. For example, glycerin injection for nerve block, H2 antagonists in colorectal cancer, or colchicine for systemic sclerosis may represent novel, hard-to-find clinical applications. If you have encountered a new and/or unusual use of a drug, submit the information to this Hospital Pharmacy feature.
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References
1.
ScottR.C., BesagF.M.C., NevilleB.G.R.Buccal midazolam and rectal diazepam for the treatment of prolonged seizures in childhood and adolescence: A randomized trial. Lancet.1999; 353: 623–6.
2.
MilliganM., DhillonS., GriffithsA.A clinical trial of single dose rectal and oral administration of diazepam for the prevention of serial seizures in adult epileptic patients. J Neurol Neurosurg Psychiatry.1984; 47: 235–40.
3.
WallaceS.J.Nasal benzodiazepines for the management of acute childhood seizure?[Letter] Lancet.1997; 349: 222.
4.
YagerJ.Y., SeshiaS.S.Sublingual lorazepam in childhood serial seizures. Am J Dis Child.1988; 142: 931–2.
5.
HoppuK., SantavuoriP.Diazepam rectal solution for home treatment of acute seizures in children. Acta Peediatr Scand.1981; 70: 369–72.
6.
KrielR.L., CloydJ.C., HadsallR.S.Home use of rectal diazepam for cluster and prolonged seizures: Efficacy, adverse reactions, quality of life, and cost analysis. Pediatr Neurol.1991; 7: 13–17.
O'ReganM., BrownJ., ClarkM.Nasal rather than rectal benzodiazepines in the treatment of acute childhood seizures. Dev Med Child Neurol.1996; 38: 1037–45.
9.
ScheepersM., CornishS., CordesL.Buccal midazolam and rectal diazepam for epilepsy. [letter] Lancet.1999; 353: 1797.
10.
KendallJ.L., ReynoldsM., GoldbergR.Intranasal midazolam in patients with status epilepticus. Ann Emerg Med.1997; 29: 415–7.
GriffithN., HowellS., MasonD.G.Intranasal midazolam for premedication of children undergoing day-case anaesthesia: Comparison of two delivery systems with assessment of intra-observer variability. Br J Anaesth.1998; 81: 865–9.
13.
HenryR.J., RuanoN., CastoD.A pharmacokinetic study of midazolam in dogs: Nasal drop vs. atomizer administration. Pediatr Dent.1998; 20: 321–6.
14.
De BoerA.G., De LeedeL.G., BreimerD.D.Drug absorption by sublingual and rectal routes. Br J Anaesthesia.1984; 56: 69–82.
15.
ScottR.C., BesagF.M., BoydS.G.Buccal absorption of midazolam: Pharmacokinetics and EEG pharmacodynamics. Epilepsia.1998; 39: 290–4.
16.
HolmesG.L.Buccal route for benzodiazepines in treatment of seizures?Lancet.1999; 353: 608–9.
17.
EllisS.J., BaddelyL.Buccal midazolam and rectal diazepam for epilepsy. [letter] Lancet.1999; 353: 1796–7.
18.
ChattopadhyayA., MorrisB., BlackburnL.Buccal midazolam and rectal diazepam for epilepsy. [letter] Lancet.1999; 353: 1798.