Acute hemorrhagic edema of infancy (AHEI) is a cutaneous leukocytoclastic vasculitis that usually occurs in children younger than 2 years of age. It is a rare disease characterized by mild fever, a violent onset of hemorrhagic skin lesions, and edema usually followed by a spontaneous and complete recovery. Although the etiology is unknown, AHEI often follows infections, drug treatment, or vaccination. In the present report, the authors describe 4 cases of AHEI and review the relevant literature.
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Cunningham BB , Caro WA, Eramo LRNeonatal acute hemorrhagic edema of childhood: case report and review of the English-language literature. Pediatr Dermatol. 1996;13:39-44.
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Yu JE, Mancini AJ, Miller MLIntussusception in an infant with acute hemorrhagic edema of infancy. Pediatr Dermatol. 2007;24:61-64.