We analyzed T-lymphocytes and their subsets in 20 patients with Bell's palsy. We used the monoclonal antibodies anti-Leulanti-Leu-2a, and anti-Leu-3a directed against T-lymphocytes and T suppressor/cytotoxic (Ts) and T helper/inducer (Th) cell subsets. Blood samples taken in the acute and convalescent phases of the illness were compared. The percentage of T cells (Leu-1+ cells) was decreased during the acute stage, mainly because of a reduction of the Th cell subset (Leu-3+ cells). No significant alteration was found in the Ts cell subset (Leu-2+ cells). The T cell and Th cell subset depressions were restored to normal within 4 to 6 weeks of the onset of the palsy. The T cell changes in the peripheral blood in the acute stage of Bell's palsy indicate the involvement of cellular immune mechanisms.
Karlsson-ParraAForsumUKlareskogLSjöbergO.A simple immunoenzyme batch staining method for the enumeration of peripheral human T lymphocyte subsets. J Immunol Methods1983; 64: 85–90
7.
SjöbergOInganäsM.Detection of Fc receptor-bearing lymphocytes by using IgG-coated latex particles. Scand J Immunol1979; 9: 547–52
8.
Manos-PujolMBuendiaEMestreM, T-lymphocyte subpopulations in Bell's palsy. In: PortmannM, ed. Proceedings of the Fifth International Symposium on the Facial Nerve. New York: Masson, 1985: 197–202
9.
AdourKKBylFMHilsingerRLKahnZMSheldonMI. The true nature of Bell's palsy: Analysis of 1,000 consecutive patients. Laryngoscope1978; 88: 787–801
De WaeleMThielemansCVan CampBKG. Characterization of immunoregulatory T cells in EBV-induced infectious mononucleosis by monoclonal antibodies. N Engl J Med1981; 304: 460–2
12.
CarneyWPRubinRHHoffmanRAHansenWPHealeyKHirschMS. Analysis of T lymphocyte subsets in cytomegalovirus mononucleosis. J Immunol1981; 126: 2114–6
13.
LifsonJDFinchSLSasakiDTEnglemanEG. Variables affecting T-lymphocyte subsets in a volunteer blood donor population. Clin Immunol Immunopathol1985; 36: 151–60
ShawGMBroderSEssexMGalloRC. Human T-cell leukemia virus: Its discovery and role in leukemogenesis and immunosuppression. In: StollermanGH, ed. Advances in internal medicine. Vol 30. Chicago: Year Book Medical Publishers, 1984: 1–27
16.
MartinMABryanTRasheedSKhanAS. Identification and cloning of endogenous retroviral sequences present in human DNA. Proc Natl Acad Sci USA1981; 78: 4892–6
17.
O'ConnellCO'BrienSNashWGCohenM.ERV3, a full-length human endogenous provirus: Chromosomal localization and evolutionary relationships. Virology1984; 138: 225–35
18.
LevyJAShimabukuroJHollanderHMillsJKaminskyL.Isolation of AIDS-associated retroviruses from cerebrospinal fluid and brain of patients with neurological symptoms. Lancet1985; 2: 586–8
19.
KoprowskiHDeFreitasECHarperME, Multiple sclerosis and human T-cell lymphotropic retroviruses. Nature1985; 318: 154–60
20.
EdströmSHannerPAndersenORosenhallUVahlneAKarlssonB.Elevated levels of myelin basic protein in CSF in relation to auditory brainstem responses in Bell's palsy. Acta Otolaryngol (Stockh)1987; 103: 198–203
21.
ReinherzELWeinerHLHauserSLCohenJADistasoJASchlossmanSF. Loss of suppressor T cells in active multiple sclerosis. N Engl J Med1980; 303: 125–9
22.
BachM-APhan-Dinh-TuyFTournierEChatenoudLBachJ-F.Deficit of suppressor T cells in active multiple sclerosis. Lancet1980; 2: 1221–3
