The presence of multiple giant cell lesions in the maxillofacial region is suggestive of hyperparathyroidism or neurofibromatosis. A case of synchronous, multiple peripheral giant cell granulomas is reported, bilaterally affecting the mandibular gums and also the upper right maxillary gingival mucosa, without concomitant systemic disease. Only 2 cases of central giant cell granulomas, and no cases of peripheral giant cell granulomas exhibiting similar characteristics, have been reported in the literature to date.
BonettiFPelosiGMartignoniG. Peripheral giant cell granuloma: Evidence for osteoclastic differentiation. Oral Surg Oral Med Oral Pathol1990; 70: 471–5.
2.
BodnerLPeistMGatotAFlissDM. Growth potential of peripheral giant cell granuloma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod1997; 83: 548–51.
3.
KfirYBuchnerAHansenLS. Reactive lesions of the gingiva. Aclinicopathological study of 741 cases. J Periodontol1980; 51: 655–61.
4.
PammerJWeningerWHullaHMazalPHorvatR. Expression of regulatory apoptotic proteins in peripheral giant cell granulomas and lesions containing osteoclast-like giant cells. J Oral Pathol Med1998; 27: 267–71.
5.
WhitakerSBWaldronCA. Central giant cell lesions of the jaws. A clinical, radiologic, and histopathologic study. Oral Surg Oral Med Oral Pathol1993; 75: 199–208.
6.
WarringtonRDReeseDJAllenG. The peripheral giant cell granuloma. Gen Dent1997; 45: 577–9.
RuggieriMPavoneVPolizziA. Unusual form of recurrent giant cell granuloma of the mandible and lower extremities in a patient with neurofibromatosis type 1. Oral Surg Oral Med Oral Pathol Oral Radiol Endod1999; 87: 67–72.
9.
ArdekianLManorRPeledMLauferD. Bilateral central giant cell granulomas in a patient with neurofibromatosis: Report of a case and review of the literature. J Oral Maxillofac Surg1999; 57: 869–72.
10.
MollerupCLBollerslevJBlichert-ToftM. Primary hyperparathyroidism: Incidence and clinical and biochemical characteristics. A demographic study. Eur J Surg1994; 160: 485–9.
11.
ParbataniRTinsleyGFDanfordMH. Primary hyperparathyroidism presenting as a giant-cell epulis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod1998; 85: 282–4.
12.
OkadaHDaviesJEYamamotoH. Brown tumor of the maxilla in a patient with secondary hyperparathyroidism: A case study involving immunohistochemistry and electron microscopy. J Oral Maxillofac Surg2000; 58: 233–8.
13.
KrauseIEisensteinBDavidovitsMCleperRTobarACalderonS. Maxillomandibular brown tumor — A rare complication of chronic renal failure. Pediatr Nephrol2000; 14: 499–501.
14.
FriedmanJMBirchPH. Type 1 neurofibromatosis: A descriptive analysis of the disorder in 1,728 patients. Am J Med Genet1997; 70: 138–43.
MighellAJRobinsonPAHumeWJ. Peripheral giant cell granuloma: A clinical study of 77 cases from 62 patients, and literature review. Oral Dis1995; 1: 12–9.
17.
AnnerothGSigurdsonA. Hyperplastic lesions of the gingiva and alveolar mucosa. A study of 175 cases. Acta Odontol Scand1983; 41: 75–86.
18.
KatsikerisNKakarantza-AngelopoulouEAngelopoulosAP. Peripheral giant cell granuloma. Clinicopathologic study of 224 new cases and review of 956 reported cases. Int J Oral Maxillofac Surg1988; 17: 94–9.
