Restricted accessResearch articleFirst published online 2025
Association of Systemic Inflammatory Response Index (SIRI) With Severity of Coronary Artery Disease in Patients With Coronary Heart Disease: A CSCD-TCM Plus Study
The systemic inflammation response index (SIRI) is a novel inflammatory biomarker that reflects the chronic inflammatory status. This study aimed to evaluate its clinical utility in determining coronary heart disease (CHD) severity. Participants in this study, sourced from the Cohort Study on the Treatment of Cardiovascular Diseases with Traditional Chinese Medicine (CSCD-TCMplus), were divided into tertiles (T) based on their SIRI values. The number of diseased vessels (single- and multi-vessel CHD) was used as a measure of disease severity, assessed by coronary angiography. Logistic regression analysis was used to investigate the relationship between SIRI and the severity of CHD. Among the 7706 participants, 6215 (80.6%) had multi-vessel disease. Logistic regression analysis revealed a significant association between SIRI and CHD severity (odds ratio [OR]: 1.09; 95% confidence interval [CI]: 1.03-1.15). Compared with males, females had a higher risk of CHD severity at the SIRI T3 tertile (OR: 1.64; 95% CI: 1.28-2.10). Also, patients >55 years of age had a greater risk than those ≤55 years old (OR: 1.93; 95% CI: 1.67-2.01). The association between SIRI and CHD severity persisted even after adjusting for confounding factors.
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