There is some evidence that periodontitis increases the risk of atherothrombosis. Abdominal aortic aneurysm (AAA) is a cardiovascular disease with specific risk factors and physiopathological mechanisms that can lead to rupture in the absence of treatment. The aim of the present systematic review was to explore the influence of periodontitis on the progression of AAAs as a specific disease. A systematic search in PubMed/MEDLINE and Embase databases was performed. Human and animal studies exploring the influence of periodontal pathogens on the progression of AAA were considered for inclusion. After systematic screening, 5 articles were included in the review. Due to the heterogeneity of the selected studies, a meta-analysis could not be performed. The descriptive analyses of the studies emphasized that periodontal pathogens or their by-products contribute to systemic and local innate immunity likely to be associated with AAA physiopathology. Periodontitis seems to play a role in the development and progression of AAA. The present systematic review suggests that the presence of periodontal bacteria in the bloodstream or in situ in the vascular lesion is a risk associated with aneurysmal disease progression.
ToghillBJSaratzisABownMJ. Abdominal aortic aneurysm – an independent disease to atherosclerosis?. Cardiovasc Pathol. 2017;27:71–5.
3.
SaratzisADattaniNBrownA. Multi-centre study on cardiovascular risk management on patients undergoing AAA surveillance. Eur J Vasc Endovasc Surg. 2017;54(1):116–22.
4.
ToghillBJSaratzisAHarrisonSCVerissimoARMallonEBBownMJ. The potential role of DNA methylation in the pathogenesis of abdominal aortic aneurysm. Atherosclerosis. 2015;241(1):121–9.
5.
SaratzisABownMJ. The genetic basis for aortic aneurysmal disease. Heart. 2014;100(12):916–22.
6.
MichelJBMartin-VenturaJLEgidoJ. Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans. Cardiovasc Res. 2011;90(1):18–27.
7.
MichelJBThaunatOHouardXMeilhacOCaligiuriGNicolettiA. Topological determinants and consequences of adventitial responses to arterial wall injury. Arterioscler Thromb Vasc Biol. 2007;27(6):1259–68.
8.
MichelJBHo-Tin-NoeB. Thrombi and neutrophils. Circ Res. 2015;116(7):1107–8.
9.
MichelJBLattionALSalzmannJL. Hormonal and cardiac effects of converting enzyme inhibition in rat myocardial infarction. Circ Res. 1988;62(4):641–50.
10.
Allenspach-PetrzilkaGEGuggenheimB. Bacterial invasion of the periodontium: an important factor in the pathogenesis of periodontitis?. J Clin Periodontol. 1983;10(6):609–17.
11.
van Palenstein HeldermanWH. Microbial etiology of periodontal disease. J Clin Periodontol. 1981;8(4):261–80.
12.
van WinkelhoffAJde GraaffJ. Microbiology in the management of destructive periodontal disease. J Clin Periodontol. 1991;18(6):406–10.
13.
EkePIWeiLBorgnakkeWS. Periodontitis prevalence in adults >/= 65 years of age, in the USA. Periodontol 2000. 2016;72(1):76–95.
14.
NazirMA. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci (Qassim). 2017;11(2):72–80.
15.
DzinkJLTannerACHaffajeeADSocranskySS. Gram negative species associated with active destructive periodontal lesions. J Clin Periodontol. 1985;12(8):648–59.
16.
HaffajeeADSocranskySSSmithCDibartS. Relation of baseline microbial parameters to future periodontal attachment loss. J Clin Periodontol. 1991;18(10):744–50.
17.
ListgartenMALevinS. Positive correlation between the proportions of subgingival spirochetes and motile bacteria and susceptibility of human subjects to periodontal deterioration. J Clin Periodontol. 1981;8(2):122–38.
18.
OffenbacherSOdleBvan DykeT. The microbial morphotypes associated with periodontal health and adult periodontitis: composition and distribution. J Clin Periodontol. 1985;12(9):736–49.
19.
SocranskySSHaffajeeADCuginiMASmithCKentRLJr. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998;25(2):134–44.
20.
SocranskySSHaffajeeADSmithCDibartS. Relation of counts of microbial species to clinical status at the sampled site. J Clin Periodontol. 1991;18(10):766–75.
21.
KinaneDFZhangPBenakanakereM. Experimental gingivitis, bacteremia and systemic biomarkers: a randomized clinical trial. J Periodontal Res. 2015;50(6):864–9.
22.
KinaneDFCullenCFJohnstonFAEvansCW. Neutrophil chemotactic behaviour in patients with early-onset forms of periodontitis (I). Leading front analysis in Boyden chambers. J Clin Periodontol. 1989;16(4):242–6.
23.
KinaneDFCullenCFJohnstonFAEvansCW. Neutrophil chemotactic behaviour in patients with early-onset forms of periodontitis (II). Assessment using the under agarose technique. J Clin Periodontol. 1989;16(4):247–51.
ChangYCYangSFLaiCCLiuJYHsiehYS. Regulation of matrix metalloproteinase production by cytokines, pharmacological agents and periodontal pathogens in human periodontal ligament fibroblast cultures. J Periodontal Res. 2002;37(3):196–203.
26.
EjeilALIgondjo-TchenSGhomrasseniSPellatBGodeauGGoglyB. Expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in healthy and diseased human gingiva. J Periodontol. 2003;74(2):188–95.
27.
DongWXiangJLiCCaoZHuangZ. Increased expression of extracellular matrix metalloproteinase inducer is associated with matrix metalloproteinase-1 and -2 in gingival tissues from patients with periodontitis. J Periodontal Res. 2009;44(1):125–32.
28.
SorsaTGursoyUKNwhatorS. Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases. Periodontol 2000. 2016;70(1):142–63.
29.
SorsaTTjaderhaneLKonttinenYT. Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann Med. 2006;38(5):306–21.
30.
MeyleJChappleI. Molecular aspects of the pathogenesis of periodontitis. Periodontol 2000. 2015;69(1):7–17.
31.
EmingilGHanBGurkanA. Matrix metalloproteinase (MMP)-8 and tissue inhibitor of MMP-1 (TIMP-1) gene polymorphisms in generalized aggressive periodontitis: gingival crevicular fluid MMP-8 and TIMP-1 levels and outcome of periodontal therapy. J Periodontol. 2014;85(8):1070–80.
32.
SapnaGGokulSBagri-ManjrekarK. Matrix metalloproteinases and periodontal diseases. Oral Dis. 2014;20(6):538–50.
33.
RuggieroSCosgareaRPotempaJPotempaBEickSChiquetM. Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C. Biochim Biophys Acta. 2013;1832(4):517–26.
34.
LetraASilvaRMRylandsRJ. MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression. J Clin Periodontol. 2012;39(8):707–16.
35.
SorsaTTervahartialaTLeppilahtiJ. Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines. Pharmacol Res. 2011;63(2):108–13.
36.
SorsaTMantylaPTervahartialaTPussinenPJGamonalJHernandezM. MMP activation in diagnostics of periodontitis and systemic inflammation. J Clin Periodontol. 2011;38(9):817–9.
37.
TravisJPikeRImamuraTPotempaJ. Porphyromonas gingivalis proteinases as virulence factors in the development of periodontitis. J Periodontal Res. 1997;32(1 Pt 2):120–5.
38.
SuzukiJIAoyamaNOgawaM. Periodontitis and cardiovascular diseases. Expert Opin Therapeutic Targets. 2010;14(10):1023–7.
39.
LeeYLHuHYHuangNHwangDKChouPChuD. Dental prophylaxis and periodontal treatment are protective factors to ischemic stroke. Stroke. 2013;44(4):1026–30.
40.
TonettiMSVan DykeTE. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Periodontol. 2013;84(suppl 4):S24–S29.
41.
TonettiMS. Periodontitis and risk for atherosclerosis: an update on intervention trials. J Clin Periodontol. 2009;36(suppl 10):15–9.
42.
BartovaJSommerovaPLyuya-MiY. Periodontitis as a risk factor of atherosclerosis. J Immunol Res. 2014;2014:636893.
43.
GeertsSONysMDeMP. Systemic release of endotoxins induced by gentle mastication: association with periodontitis severity. J Periodontol. 2002;73(1):73–8.
44.
Gaetti-JardimEJrMarcelinoSLFeitosaACRomitoGAAvila-CamposMJ. Quantitative detection of periodontopathic bacteria in atherosclerotic plaques from coronary arteries. J Med Microbiol. 2009;58(Pt 12):1568–75.
45.
WadaKKamisakiY. Roles of oral bacteria in cardiovascular diseases – from molecular mechanisms to clinical cases: involvement of Porphyromonas gingivalis in the development of human aortic aneurysm. J Pharmacol Sci. 2010;113(2):115–9.
46.
BoillotADemmerRTMallatZ. Periodontal microbiota and phospholipases: the Oral Infections and Vascular Disease Epidemiology Study (INVEST). Atherosclerosis. 2015;242(2):418–23.
47.
MahalakshmiKKrishnanPArumugamSB. Association of periodontopathic anaerobic bacterial co-occurrence to atherosclerosis – a cross-sectional study. Anaerobe. 2017;44:66–72.
48.
SzulcMKustrzyckiWJanczakDMichalowskaDBaczynskaDRadwan-OczkoM. Presence of periodontopathic bacteria DNA in atheromatous plaques from coronary and carotid arteries. Biomed Res Int. 2015;2015:825397.
49.
RathSKMukherjeeMKaushikRSenSKumarM. Periodontal pathogens in atheromatous plaque. Indian J Pathol Microbiol. 2014;57(2):259–64.
50.
FigueroESanchez-BeltranMCuesta-FrechosoS. Detection of periodontal bacteria in atheromatous plaque by nested polymerase chain reaction. J Periodontol. 2011;82(10):1469–77.
51.
ZarembaMGorskaRSuwalskiPKowalskiJ. Evaluation of the incidence of periodontitis-associated bacteria in the atherosclerotic plaque of coronary blood vessels. J Periodontol. 2007;78(2):322–7.
52.
Van DykeTEvan WinkelhoffAJ. Infection and inflammatory mechanisms. J Periodontol. 2013;84(suppl 4):S1–S7.
53.
AmarSGokceNMorganSLoukideliMVan DykeTEVitaJA. Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation. Arterioscler Thromb Vasc Biol. 2003;23(7):1245–9.
54.
ElterJRHinderliterALOffenbacherS. The effects of periodontal therapy on vascular endothelial function: a pilot trial. Am Heart J. 2006;151(1):47.
55.
EngelmannBMassbergS. Thrombosis as an intravascular effector of innate immunity. Nat Rev Immunol. 2013;13(1):34–45.
56.
MassbergSGrahlLvon BruehlML. Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases. Nat Med. 2010;16(8):887–96.
57.
MartinodKWagnerDD. Thrombosis: tangled up in NETs. Blood. 2014;123(18):2768–76.
58.
Thoden van VelzenSKAbraham-InpijnLMoorerWR. Plaque and systemic disease: a reappraisal of the focal infection concept. J Clin Periodontol. 1984;11(4):209–20.
AlsacJMDelboscSRouerM. Fucoidan interferes with Porphyromonas gingivalis-induced aneurysm enlargement by decreasing neutrophil activation. J Vasc Surg. 2013;57(3):796–805.
62.
KuriharaNInoueYIwaiTUmedaMHuangYIshikawaI. Detection and localization of periodontopathic bacteria in abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2004;28(5):553–8.
63.
Marques da SilvaRCaugantDALingaasPSGeiranOTronstadLOlsenI. Detection of Actinobacillus actinomycetemcomitans but not bacteria of the red complex in aortic aneurysms by multiplex polymerase chain reaction. J Periodontol. 2005;76(4):590–4.
64.
NakanoKWadaKNomuraR. Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis. Oral Dis. 2011;17(4):370–8.
65.
SuzukiJAoyamaNAokiM. High incidence of periodontitis in Japanese patients with abdominal aortic aneurysm. Int Heart J. 2014;55(3):268–70.
66.
HalmeSJuvonenTLaurilaA. Chlamydia pneumoniae reactive T lymphocytes in the walls of abdominal aortic aneurysms. Eur J Clin Invest. 1999;29(6):546–52.
67.
LindholtJSJuulSVammenSLindIFastingHHennebergEW. Immunoglobulin A antibodies against Chlamydia pneumoniae are associated with expansion of abdominal aortic aneurysm. Br J Surg. 1999;86(5):634–8.
68.
KarlssonLGnarpeJNaasJ. Detection of viable Chlamydia pneumoniae in abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2000;19(6):630–5.
69.
LiberatiAAltmanDGTetzlaffJ. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.
70.
RichardsonWS. On questions, background and foreground. In: WilsonMC, ed. Evidence Based Healthcare Newsletter; 1997;17:8–9.
71.
SheaBJGrimshawJMWellsGA. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. 2007;7:10.
72.
HooijmansCRRoversMMde VriesRBLeenaarsMRitskes-HoitingaMLangendamMW. SYRCLE’s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;14:43.
73.
RooneyAABoylesALWolfeMSBucherJRThayerKA. Systematic review and evidence integration for literature-based environmental health science assessments. Environ Health Perspect. 2014;122(7):711–8.
74.
AoyamaNSuzukiJOgawaM. Toll-like receptor-2 plays a fundamental role in periodontal bacteria-accelerated abdominal aortic aneurysms. Circ J. 2013;77(6):1565–73.
75.
DelboscSAlsacJMJourneC. Porphyromonas gingivalis participates in pathogenesis of human abdominal aortic aneurysm by neutrophil activation. Proof of concept in rats. PLoS One. 2011;6(4):e18679.
76.
FontaineVTouatZMtairag elM. Role of leukocyte elastase in preventing cellular re-colonization of the mural thrombus. Am J Pathol. 2004;164(6):2077–87.
77.
HouardXTouatZOllivierV. Mediators of neutrophil recruitment in human abdominal aortic aneurysms. Cardiovasc Res. 2009;82(3):532–41.
78.
AoyamaNSuzukiJIOgawaM. A periodontal pathogen accelerates the progression of abdominal aortic aneurysm via toll-like receptor-2 signaling. Circulation. 2018;124:A9403.
79.
SasajimaTTakanoYHiraishiY. High accumulation of plasminogen and tissue plasminogen activator at the flow surface of mural fibrin in the human arterial system. J Vasc Surg. 2000;32(2):374–82.
80.
TakagiHManabeHKawaiNGotoSNUmemotoT. Plasma tissue plasminogen activator and abdominal aortic aneurysm presence: a systematic review and meta-analysis. Ann Vasc Surg. 2010;24(5):686–9.
81.
AmanoA. Host–parasite interactions in periodontitis: microbial pathogenicity and innate immunity. Periodontol 2000. 2010;54(1):9–14.
82.
AmanoA. Host–parasite interactions in periodontitis: subgingival infection and host sensing. Periodontol 2000. 2010;52(1):7–11.
83.
SchenkeinHA. Host responses in maintaining periodontal health and determining periodontal disease. Periodontol 2000. 2006;40:77–93.
FornerLLarsenTKilianMHolmstrupP. Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J Clin Periodontol. 2006;33(6):401–7.
86.
MaharajBCoovadiaYVayejAC. An investigation of the frequency of bacteraemia following dental extraction, tooth brushing and chewing. Cardiovasc J Afr. 2012;23(6):340–4.
87.
CraigRGPernatAMPecoits-FilhoRLevinNWKotankoP. Periodontal diseases and systemic inflammation. Semin Dial. 2013;26(1):23–8.
88.
Van DykeTEvan WinkelhoffAJ. Infection and inflammatory mechanisms. J Clin Periodontol. 2013;40(suppl 14):S1–S7.
89.
LindenGJHerzbergMC. Periodontitis and systemic diseases: a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol. 2013;40(suppl 14):S20–S23.
90.
PapapanouPN. Systemic effects of periodontitis: lessons learned from research on atherosclerotic vascular disease and adverse pregnancy outcomes. Int Dent J. 2015;65(6):283–91.
91.
MustaphaIZDebreySOladubuMUgarteR. Markers of systemic bacterial exposure in periodontal disease and cardiovascular disease risk: a systematic review and meta-analysis. J Periodontol. 2007;78(12):2289–302.
92.
AbarigaSAWhitcombBW. Periodontitis and gestational diabetes mellitus: a systematic review and meta-analysis of observational studies. BMC Pregnancy Childbirth. 2016;16(1):344.
93.
WangTFJenIAChouCLeiYP. Effects of periodontal therapy on metabolic control in patients with type 2 diabetes mellitus and periodontal disease: a meta-analysis. Medicine (Baltimore). 2014;93(28):e292.
94.
ArmingoharZJorgensenJJKristoffersenAKAbesha-BelayEOlsenI. Bacteria and bacterial DNA in atherosclerotic plaque and aneurysmal wall biopsies from patients with and without periodontitis. J Oral Microbiol. 2014;6. doi:10.3402/jom.v6.23408.
95.
TonettiMSVan DykeTE. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol. 2013;40(suppl 14):S24–S29.
96.
FigueroELindahlCMarínMJ. Quantification of periodontal pathogens in vascular, blood, and subgingival samples from patients with peripheral arterial disease or abdominal aortic aneurysms. J Periodontol. 2014;85(9):1182–93.
97.
OlsenIProgulske-FoxA. Invasion of Porphyromonas gingivalis strains into vascular cells and tissue. J Oral Microbiol. 2015;7:28788.
98.
BelangerMKozarovESongHWhitlockJProgulske-FoxA. Both the unique and repeat regions of the Porphyromonas gingivalis hemagglutin A are involved in adhesion and invasion of host cells. Anaerobe. 2012;18(1):128–34.
99.
LiuFWangYXuJHuRDengH. Effects of Porphyromonas gingivalis lipopolysaccharide on the expression of key genes involved in cholesterol metabolism in macrophages. Arch Med Sci. 2016;12(5):959–67.
LiXYWangCXiangXRChenFCYangCMWuJ. Porphyromonas gingivalis lipopolysaccharide increases lipid accumulation by affecting CD36 and ATP-binding cassette transporter A1 in macrophages. Oncol Rep. 2013;30(3):1329–36.
102.
JaramilloALafaurieGIMillanLV. Association between periodontal disease and plasma levels of cholesterol and triglycerides. Colomb Med (Cali). 2013;44(2):80–6.
103.
MaekawaTTakahashiNTabetaK. Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. PLoS One. 2011;6(5):e20240.
ParaskevasKIMikhailidisDPGiannoukasAD. Periodontitis and abdominal aortic aneurysms: a random association or a pathogenetic link?. Int Angiol. 2009;28(6):431–3.
106.
CrowtherMGoodallSJonesJLBellPRThompsonMM. Increased matrix metalloproteinase 2 expression in vascular smooth muscle cells cultured from abdominal aortic aneurysms. J Vasc Surg. 2000;32(3):575–83.
107.
DawsonJCockerillGChokeELoftusIThompsonMM. Circulating cytokines in patients with abdominal aortic aneurysms. Ann N Y Acad Sci. 2006;1085:324–6.
108.
WallinderJBergqvistDHenrikssonAE. Proinflammatory and anti-inflammatory cytokine balance in patients with abdominal aortic aneurysm and the impact of aneurysm size. Vasc Endovasc Surg. 2009;43(3):258–61.
SpeelmanLHellenthalFAPulinxB. The influence of wall stress on AAA growth and biomarkers. Eur J Vasc Endovasc Surg. 2010;39(4):410–6.
111.
HellenthalFABuurmanWAWodzigWKSchurinkGW. Biomarkers of AAA progression. Part 1: extracellular matrix degeneration. Nat Rev Cardiol. 2009;6(7):464–74.
112.
PetersenEWagbergFAngquistKA. Proteolysis of the abdominal aortic aneurysm wall and the association with rupture. Eur J Vasc Endovasc Surg. 2002;23(2):153–7.
113.
KadoglouNPLiapisCD. Matrix metalloproteinases: contribution to pathogenesis, diagnosis, surveillance and treatment of abdominal aortic aneurysms. Curr Med Res Opin. 2004;20(4):419–32.
114.
PalomboDMaioneMCifielloBIUdiniMMaggioDLupoM. Matrix metalloproteinases. Their role in degenerative chronic diseases of abdominal aorta. J Cardiovasc Surg (Torino). 1999;40(2):257–60.
115.
CourtoisANusgensBVHustinxR. 18F-FDG uptake assessed by PET/CT in abdominal aortic aneurysms is associated with cellular and molecular alterations prefacing wall deterioration and rupture. J Nucl Med. 2013;54(10):1740–7.
116.
FolkessonMSilveiraAErikssonPSwedenborgJ. Protease activity in the multi-layered intra-luminal thrombus of abdominal aortic aneurysms. Atherosclerosis. 2011;218(2):294–9.
117.
KimHWBlomkalnsALOgbiM. Role of myeloperoxidase in abdominal aortic aneurysm formation: mitigation by taurine. Am J Physiol Heart Circ Physiol. 2017;313(6):H1168–79.
ThompsonRWHolmesDRMertensRA. Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages. J Clin Invest. 1995;96(1):318–26.
120.
KeelingWBArmstrongPAStonePABandykDFShamesML. An overview of matrix metalloproteinases in the pathogenesis and treatment of abdominal aortic aneurysms. Vasc Endovasc Surg. 2005;39(6):457–64.
121.
TouatZOllivierVDaiJ. Renewal of mural thrombus releases plasma markers and is involved in aortic abdominal aneurysm evolution. Am J Pathol. 2006;168(3):1022–30.
122.
SwedenborgJErikssonP. The intraluminal thrombus as a source of proteolytic activity. Ann N Y Acad Sci. 2006;1085:133–8.
123.
NakagomiA. Effect of Toll-like receptor in periodontal bacteria-accelerated abdominal aortic aneurysms. Circ J. 2013;77(6):1414–5.
124.
DeshpandeRGKhanMBGencoCA. Invasion of aortic and heart endothelial cells by Porphyromonas gingivalis. Infect Immun. 1998;66(11):5337–43.
125.
DeshpandeRGKhanMGencoCA. Invasion strategies of the oral pathogen porphyromonas gingivalis: implications for cardiovascular disease. Invas Metastasis. 1998;18(2):57–69.
126.
HiroseKIsogaiEUedaI. Porphyromonas gingivalis fimbriae induce adhesion of monocytic cell line U937 to endothelial cells. Microbiol Immunol. 2000;44(1):17–22.
127.
KhlgatianMNassarHChouHHGibsonFC3rdGencoCA. Fimbria-dependent activation of cell adhesion molecule expression in Porphyromonas gingivalis-infected endothelial cells. Infect Immun. 2002;70(1):257–67.
128.
NassarHChouHHKhlgatianMGibsonFC3rdVan DykeTEGencoCA. Role for fimbriae and lysine-specific cysteine proteinase gingipain K in expression of interleukin-8 and monocyte chemoattractant protein in Porphyromonas gingivalis-infected endothelial cells. Infect Immun. 2002;70(1):268–76.
129.
Ramos-MozoPMadrigal-MatuteJMartinez-PinnaR. Proteomic analysis of polymorphonuclear neutrophils identifies catalase as a novel biomarker of abdominal aortic aneurysm: potential implication of oxidative stress in abdominal aortic aneurysm progression. Arterioscler Thromb Vasc Biol. 2011;31(12):3011–9.
130.
McCormickMLGavrilaDWeintraubNL. Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 2007;27(3):461–9.
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