Carbapenem-resistant Acinetobacter baumannii isolates were obtained from 50 patients between July 2011 and July 2012 at the University Hospital A Coruña (NW Spain). These multidrug-resistant isolates, which belonged to a single clone, remained only susceptible to tigecycline, minocycline, and colistin and produced the carbapenem-hydrolyzing oxacillinase, OXA-23. This is the first reported outbreak of OXA-23-producing A. baumannii isolates in Spain.
BartualS.G., SeifertH., HipplerC., LuzonM.A., WisplinghoffH., Rodriguez-ValeraF.2005. Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumannii. J. Clin. Microbiol., 43:4382–4390.
3.
BouG., CerveroG., DominguezM.A., QueredaC., Martinez-BeltranJ.2000. Characterization of a nosocomial outbreak caused by a multiresistant Acinetobacter baumannii strain with a carbapenem-hydrolyzing enzyme: high-level carbapenem resistance in A. baumannii is not due solely to the presence of beta-lactamases. J. Clin. Microbiol., 38:3299–3305.
4.
BriganteG., MigliavaccaR., BramatiS., MottaE., NucleoE., ManentiM., et al.2012. Emergence and spread of a multidrug-resistant Acinetobacter baumannii clone producing both the carbapenemase OXA-23 and the 16S rRNA methylase ArmA. J. Med. Microbiol., 61(Pt 5):653–661.
5.
CorvecS., PoirelL., NaasT., DrugeonH., NordmannP.2007. Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii. Antimicrob. Agents Chemother., 51:1530–1533.
6.
DijkshoornL., NemecA., SeifertH.2007. An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Nat. Rev. Microbiol., 5:939–951.
7.
EspinalP., MaciaM.D., RocaI., GatoE., RuizE., Fernandez-CuencaF., et al.2012. First report of an OXA-23 carbapenemase-producing Acinetobacter baumannii clinical isolate related to Tn2006 in Spain. Antimicrob. Agents Chemother., 57:589–591.
8.
GrossoF., QuinteiraS., PeixeL.2011. Understanding the dynamics of imipenem-resistant Acinetobacter baumannii lineages within Portugal. Clin. Microbiol. Infect., 17:1275–1279.
9.
KohlenbergA., BrummerS., HigginsP.G., SohrD., PieningB.C., de GrahlC., et al.2009. Outbreak of carbapenem-resistant Acinetobacter baumannii carrying the carbapenemase OXA-23 in a German university medical centre. J. Med. Microbiol., 58(Pt 11):1499–1507.
10.
LiakopoulosA., MiriagouV., KatsifasE.A., KaragouniA.D., DaikosG.L., TzouvelekisL.S., et al.2012. Identification of OXA-23-producing Acinetobacter baumannii in Greece, 2010 to 2011. Euro. Surveill., 17:pii:20117.
11.
ManageiroV., Jones-DiasD., FerreiraE., LouroD., CanicaM.2012. Genetic diversity and clonal evolution of carbapenem-resistant Acinetobacter baumannii isolates from Portugal and the dissemination of ST118. Int. J. Antimicrob. Agents, 40:398–403.
12.
MugnierP.D., PoirelL., NaasT., NordmannP.2010. Worldwide dissemination of the blaOXA-23 carbapenemase gene of Acinetobacter baumannii. Emerg. Infect. Dis., 16:35–40.
13.
PetersenK., CannegieterS.C., van der ReijdenT.J., van StrijenB., YouD.M., BabelB.S., et al.2011. Diversity and clinical impact of Acinetobacter baumannii colonization and infection at a military medical center. J. Clin. Microbiol., 49:159–166.
14.
PeymaniA., HigginsP.G., NahaeiM.R., FarajniaS., SeifertH.2012. Characterisation and clonal dissemination of OXA-23-producing Acinetobacter baumannii in Tabriz, northwest Iran. Int. J. Antimicrob. Agents, 39:526–528.
15.
PoirelL., NordmannP.2006. Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology. Clin. Microbiol. Infect., 12:826–836.
16.
StoevaT., HigginsP.G., SavovE., MarkovskaR., MitovI., SeifertH.2009. Nosocomial spread of OXA-23 and OXA-58 beta-lactamase-producing Acinetobacter baumannii in a Bulgarian hospital. J. Antimicrob. Chemother., 63:618–620.
17.
TurtonJ.F., GabrielS.N., ValderreyC., KaufmannM.E., PittT.L.2007. Use of sequence-based typing and multiplex PCR to identify clonal lineages of outbreak strains of Acinetobacter baumannii. Clin. Microbiol. Infect., 13:807–815.
18.
ZhangL., DingG., WeiL., PanX., MeiL., ZhangY., et al.2011. Establishment of a novel target-based real-time quantitative PCR method for Acinetobacter baumannii detection. Diagn. Mol. Pathol., 20:242–248.