Restricted accessCase reportFirst published online 2012-10
Evolution of Vitreomacular Traction Following the Use of the Dexamethasone Intravitreal Implant (Ozurdex) in the Treatment of Macular Edema Secondary to Central Retinal Vein Occlusion
To report a case of worsening of vitreomacular traction (VMT) after the dexamethasone intravitreal implant (Ozurdex; Allergan, Inc., Irvine, CA) for the treatment of macular edema secondary to central retinal vein occlusion (CRVO).
Case:
A 71-year-old man who presented with macular edema secondary to CRVO was treated by intravitreal injections of bevacizumab followed by Ozurdex.
Results:
VMT developed during the course of treatment and became more evident when macular edema resolved after treatment with Ozurdex.
Conclusion:
VMT may become apparent and worsen after resolution of macular edema treated with intravitreal Ozurdex.
Get full access to this article
View all access options for this article.
References
1.
HallerJ., BandelloF., BelfortR.et al.Novel dexamethasone drug delivery system in treatment of RVO. Ophthalmology, 117:1134–1146. 2010.
2.
HallerJ., BandelloF., BelfortR.et al.Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein occlusion twelve-month study results. Ophthalmology, 118:2453–2460. 2011.
SCORE Study Research Group. A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) Study report 6. Arch. Ophthalmol., 127:1115–1128. 2009.
5.
CampochiaroP.A., HafizG., ShahS.M.et al.Ranibizumab for macular edema due to retinal vein occlusions: implication of VEGF as a critical stimulator. Mol. Ther., 16:791–799. 2008.
6.
BrownD.M., CampochiaroP.A., SinghR.P.et al.Ranibizumab for macular edema following central retinal vein occlusion: six-month primary end point results of a phase III study. Ophthalmology, 117:1124–1133. 2010.
7.
CampochiaroP.A., HeierJ.S., FeinerL.et al.Ranibizumab for macular edema following branch retinal vein occlusion: six-month primary end point results of a phase III study. Ophthalmology, 117:1102–1112. 2010.
8.
SCORE Study Research Group. A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with observation to treat vision loss associated with macular edema secondary to central retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) Study report 5. Arch. Ophthalmol., 127:1101–1114. 2009.
9.
RamezaniA., EntezariM., MoradianS.et al.Intravitreal triamcinolone for acute central retinal vein occlusion: a randomized clinical trial. Graefes Arch. Clin. Exp. Ophthalmol., 244:1601–1606. 2006.
10.
JaffeN.S.Vitreous traction at the posterior pole of the fundus due to alternations in the vitreous posterior. Trans. Am. Acad. Ophthalmol. Otolaryngol., 71:642–652. 1967.
11.
KoizumiR., SpaideR.F., FisherY.L., FreundK.B., KlancnikJ.M.Jr., YannuzziL.A.Three-dimensional evaluation of vitreomacular traction and epiretinal membrane using spectral-domain optical coherence tomography. Am. J. Ophthalmol., 145:509–517. 2008.
12.
ChangL.K., FineH.F., SpaideR.F., KoizumiH., GrossniklausH.E.Ultrastructural correlation of spectral-domain optical coherence tomography findings in vitreomacular traction syndrome. Am. J. Ophthalmol., 146:121–127. 2008.
13.
GandorferA., RohlederM., KampikA.Epiretinal pathology of vitreomacular traction syndrome. Br. J. Ophthalmol., 86:902–909. 2002.
14.
BhagatN., GoldbergM.F., GasconP.et al.Central retinal vein occlusion: report of two familial cases. Eur. J. Ophthalmol., 9:181–195. 1999.
15.
SpaideR.F., ChangL.K., KlancnikJ.M., YannuzziL.A., SorensonJ., SlakterJ.S., FreundK.B., KleinR.Prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion. Am. J. Ophthalmol., 147:298–306. 2009.
16.
OdrobinaD., MichalewskaZ., MichalewskiJ., DzięgielewskiK., NawrockiJ.Long-term evaluation of vitreomacular traction disorder in spectral-domain optical coherence tomography. Retina, 31:324–331. 2011.
17.
HikichiT., YoshidaA., TrempeC.L.Course of vitreomacular traction syndrome. Am. J. Ophthalmol., 119:55–61. 1995.
