Effect of Captopril (an Angiotensin-Converting Enzyme Inhibitor) on Intraocular Pressure in Healthy Human Volunteers

Abstract

ABSTRACT

The renin-angiotensin-aldosterone system is important in the regulation of body fluids. Angiotensin-converting enzyme (ACE) which forms angiotensin II from angiotensin I, is known to be present in human ocular tissue. In rabbits, some topically applied ACE inhibitors including captopril have been shown to reduce IOP with a magnitude and duration comparable to that of topical 0.5% timolol. Captopril in a 50mg single oral dose, which had a significant effect on blood pressure, had no significant effect on IOP over a 4 hour period.