Purpose: To evaluate subconjunctival mitomycin C (MMC) injection efficacy and safety in patients with failing glaucoma non-penetrating filtering blebs. Methods: Twenty-eight eyes were consecutively
recruited for this study. Only one eye for each patient was randomly selected. All the recruited patients had glaucoma and uncontrolled intraocular pressure after a non-penetrating filtering glaucoma surgery
and/or a pathological aspect of the filtering bleb (i.e., vascularized and/or encysted). One or more MMC injections were performed under the conjunctiva closed to the bleb to improve filtration. Local effects
and complications of subconjunctival MMC injections were analyzed. Results: Out of the 28 patients, 21 (75%) had MMC also applied intraoperatively. The mean postoperative IOP before MMC injections
was 17 ± 6.6 mmHg. The final IOP after MMC injections was 13.9 ± 2.9 mmHg after a mean follow-up of 6 months. A total of 67 subconjunctival MMC injections were performed with a mean of 2.9
(ranging from 1 to 5) injections per patient. The only complication found to be possibly related to MMC injections was two cases of corneal Dellen. Conclusion: From these preliminary results, subconjunctival
MMC injections in selected cases appear to be not only safe but also effective in promoting further the postoperative IOP drop.
