Geometric Invariant Core for the C L and C H 1 Domains of Immunoglobulin Molecules

Abstract

A previously developed algorithmic method for identifying a geometric invariant of protein structures, termed geometrical core, is extended to the C _L and C_H1 domains of immunoglobulin molecules. The method uses the matrix of C_α − C_α distances and does not require the usual superposition of structures. The result of applying the algorithm to 53 Immunoglobulin structures led to the identification of two geometrical core sets of C_α atom positions for the C _L and C_H1 domains.