Large animal toxicity studies, also called nonrodent studies, are very different from rodent (rat, mouse, guinea pig, and rabbit) studies in significant ways. The differences between the two study types, as well as the advantages and disadvantages of each, are evaluated in detail. Also examined are causes for selecting specific species, regulatory requirements for using nonrodent species, and an overview of major species characteristics for dogs, primates, pigs, and ferrets.
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