Response to “Alternative Models for Carcinogenicity Testing: Weight of Evidence Across Models” Sam Cohen,Toxicologic Pathology (2001) 29(Suppl.): 183—190

Ashby J. (2001). Expectations for transgenic rodent cancer bioassaymodels . Toxicol Pathol 29(Suppl.): 177—182.

Iarc (1999). Consensus report . In: The Use ofShort-andMedium-term Tests for Carcinogens and Data on Genetic Effects in carcinogeni c Hazard Evaluation, McGregor B , Rice JM , Venitt S , (eds). IARC Scientific Publications No. 146, International Agency for Research on Cancer, Lyon.

Gibson DP , Aardema MJ , Kerckaert GA , Brauninger RM , LeBoeuf RA (1995). Detection of aneuploidy-inducing carcinogens in the Syrian hamster embryo cell transformation assay. Mutat Res 343: 7—24.

Isfort RJ , Kerckaert GA , LeBoeuf R.A. (1996a). Comparison of the standard and reduced pH Syrian hamster embryo (SHE) cell in vitro cell transformation assay to predict the carcinogenic potential of chemicals. Mutat Res 356: 11—63.

Isfort RJ , LeBoeuf RA (1996b) Application of in vitro cell transformation assays to predict the carcinogenic potential of chemicals. Mutat Res 365: 161— 173.

Kerckaert GA , LeBoeuf RA , Isfort RJ (1998). Assessing the predictivenes s of the Syrian hamster embryo cell transformation assay for determining the rodent carcinogenic potential of single ring aromatic/nitroaromatic amine compounds. Toxicol Sci 41: 189—197.

Kerckaert GA , Brauninger RM , LeBoeuf RA , Isfort RJ (1996a) Use of the Syrian hamster embryo cell transformation assay for carcinogenicity prediction of chemicals currently being tested by the national toxicology program in rodent bioassays. Environ Health Perspect 104(Suppl 5): 1075— 1084.

Kerckaert GA , Isfort RJ , Carr GJ , Aardema MJ (1996b). A comprehensive protocol for conducting the Syrian hamster embryo cell transformation assay at pH 6.70. Mutat Res 356: 65—84.

LeBoeuf RA , Kerckaert GA , Poiley J. , Raineri R. (1989). An interlaboratory comparison of enhanced morphological transformation of Syrian hamster embryo cells cultured under conditions of reduced bicarbonate concentration and pH. Mutat Res 222: 205—218.

LeBoeuf RA , Kerckaert GA , Aardema MJ , Gibson DP , Brauninger RM , Isfort RJ (1996). The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals [review]. Mutat Res 356: 85—127.

LeBoeuf RA , Kerckaert GA , Aardema MJ , Isfort RJ (1999). Use of Syrian hamster embryo and BALB/c 3T3 cell transformation for assessing the carcinogenicity potential of chemicals. In: The Use of Short- and Medium-term Tests for Carcinogenic Hazard Evaluation, McGregor DB , Rice JM , Venitt S (eds). IARC Scientific Publications No. 146, pp 409—425.

Mauthe RJ , Gibson DP , Bunch RT , Custer L. (2001). The Syrian hamster embryo (SHE) cell transformation assay: Review of the methods and results. Toxicol Pathol 29(Suppl.): 138—146.

Mussler B. , Schwind K-R. , Englehardt G. (2001). Evaluation of the Syrian hamster embryonic (SHE) assay as predictive screening Tool in carcinogenic hazard identification. Toxicol Pathol 29(Suppl.): 317—318.

Swierenga and Yamasaki (1999). Performance of tests for cell transformation and gap-junction intercellular communication for detecting nongentoxic carcinogenic activity. In: Mechanisms of Carcinogenesis in Risk Identification, Vainio H , Magee PN , McGregor DB , McMichael AJ (eds). IARC, Lyon, France, pp 165—193.