Leiomyosarcomas (LMSs) are rare malignant mesenchymal tumors which show smooth-muscle differentiation. Most LMSs involving the oral tissues primarily affect the maxillary sinus, the maxillary or mandibular bone. We present a case of LMS of the mandibular alveolar mucosa, arising in a 12-year-old male child from Ethiopia. A malignant spindle cell-like neoplasm was diagnosed on clinical and radiographic findings as well as on incisional biopsy. The tumor was resected with wide margins. The following histopathologic examination with additional immunohistochemical studies secured the diagnosis LMS. Microscopically, the spindle-shaped tumor cells were arranged in an interlacing fascicular pattern and contained oval to elongated, blunt-ended (cigar-shaped) nuclei. The immunohistochemical examination showed immunoreactive tumor cells for vimentin, actin, desmin, and H-caldesmon, which is pathognomonic for LMS. Immunohistochemical studies are mandatory to differentiate the LMS from other similar spindle cell neoplastic lesions. Radical resection with safety margins and a lifelong periodic follow-up has to be recommended.
EzingerFMWeissSSoft Tissue Tumors. 2nd edSt. LouisC. V. Mosby Company1988402–421
2.
GustafsonPWillénHBaldetorpBFernöMÅkermanMRydholmASoft tissue leiomyosarcoma. A population-based epidemiologic and prognostic study of 48 patients, including cellular DNA contentCancer1992701114–119
3.
SkoulakisCChimonaTSTsirevelouPPapadakisCESubcutaneus leiomyosarcoma of the neck: a case reportCases J2010352
4.
FarmanAGKaySOral leiomyosarcoma. Report of a case and review of the literature pertaining to smooth-muscle tumors of the oral cavityOral Surg Oral Med Oral Pathol1977433402–409
5.
FreedmanPDJonesACKerpelSMEpithelioid leiomyosarcoma of the oral cavity: report of two cases and review of the literatureJ Oral Maxillofac Surg1993518928–932
6.
MilesAEWaterhouseJPA leiomyosarcoma of the oral cavity with metastasis to lymph-glandsJ Pathol Bacteriol196283551–555
7.
PoonCKKwanPCYinNTChaoSYLeiomyosarcoma of gingiva: report of a case and review of the literatureJ Oral Maxillofac Surg19874510888–892
8.
KissaneJMAnderson's Pathology. 9th edSt. LouisC. V. Mosby Company1861
9.
PiattelliAArteseLLeiomyosarcoma of the tongue: a case reportJ Oral Maxillofac Surg1995536698–701
10.
EthunandanMStokesCHigginsBSpeddingAWayCBrennanPPrimary oral leiomyosarcoma: a clinico-pathologic study and analysis of prognostic factorsInt J Oral Maxillofac Surg2007365409–416
11.
VilosGARapidisADLagogiannisGDApostolidisCLeiomyosarcomas of the oral tissues: clinicopathologic analysis of 50 casesJ Oral Maxillofac Surg200563101461–1477
12.
StoutAPHillWTLeiomyosarcoma of the superficial soft tissuesCancer1958114844–854
13.
FuYSPerzinKHNonepithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx: a clinicopathologic study. IV. Smooth muscle tumors (leiomyoma, leiomyosarcoma)Cancer19753551300–1308
14.
PhillipsHBrownALeiomyosarcoma: report of caseJ Oral Surg1971293194–195
15.
IzumiKMaedaTChengJSakuTPrimary leiomyosarcoma of the maxilla with regional lymph node metastasis. Report of a case and review of the literatureOral Surg Oral Med Oral Pathol Oral Radiol Endod1995803310–319
16.
KratochvilFJDIIIMacGregorSDBudnickSDHewan-LoweKAllsupHWLeiomyosarcoma of the maxilla. Report of a case and review of the literatureOral Surg Oral Med Oral Pathol1982546647–655
17.
Martin-HirschDPHabashiSBenbowEWFarringtonWTPost-irradiation leiomyosarcoma of the maxillaJ Laryngol Otol1991105121068–1071
18.
SanerkinNGPrimary leiomyosarcoma of the bone and its comparison with fibrosarcomaCancer19794441375–1387
19.
NevilleBWDammDDAllenCMBouquoutJEOral and Maxillofacial PathologyPhiladelphia, PAW. B. Saunders1995406–407
20.
RodiniCOPontesFSCPontesHARSantosPSSMagalhãesMGPintoDSJrOral leiomyosarcomas: report of two cases with immunohistochemical profileOral Surg Oral Med Oral Pathol Oral Radiol Endod20071044e50–e55
21.
SandruckJEscobarPLurainJFishmanDUterine leiomyosarcoma metastatic to the sphenoid sinus: a case report and review of the literatureGynecol Oncol2004922701–704
22.
FieldsJPHelwigEBLeiomyosarcoma of the skin and subcutaneous tissueCancer1981471156–169
23.
MartisCLeiomyosarcoma of the maxilla: report of two casesJ Oral Surg197836162–65
24.
WileAGEvansHLRomsdahlMMLeiomyosarcoma of soft tissue: a clinicopathologic studyCancer19814841022–1032
25.
MillerPDJrA classification of marginal tissue recessionInt J Periodontics Restorative Dent1985528–13
26.
SumidaTHamakawaHOtsukaKTaniokaHLeiomyosarcoma of the maxillary sinus with cervical lymph node metastasisJ Oral Maxillofac Surg2001595568–571
27.
IzumiKMaedaTChengJSakuTPrimary leiomyosarcoma of the maxilla with regional lymph node metastasis. Report of a case and review of the literatureOral Surg Oral Med Oral Pathol Oral Radiol Endod1995803310–319
28.
GabbianiGKapanciYBarazzonePFrankeWWImmunochemical identification of intermediate-sized filaments in human neoplastic cells. A diagnostic aid for the surgical pathologistAm J Pathol19811043206–216
29.
SchenbergMESlootwegPJKooleRLeiomyosarcomas of the oral cavity. Report of four cases and review of the literatureJ Craniomaxillofac Surg1993218342–347
30.
KuruvillaAWenigBMHumphreyDMHeffnerDKLeiomyosarcoma of the sinonasal tract. A clinicopathologic study of nine casesArch Otolaryngol Head Neck Surg1990116111278–1286
31.
ChangAERosenbergSAGlatsteinEAntmanKHSarcomas of soft tissues In: DeVitaVTHellmannSRosenbergSACancer Principles and Practice of OncologyPhiladelphia, PALippincott19891345–1398
32.
JosephsonRLBlairRLBedardYCLeiomyosarcoma of the nose and paranasal sinusesOtolaryngol Head Neck Surg1985932270–274
