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Abstract

Study Design

A retrospective cohort study.

Objectives

To determine the outcome and any differences in the clinical results of three different surgical methods for lumbar disk herniation and to assess the effect of factors that could predict the outcome of surgery.

Methods

We evaluated 148 patients who had operations for lumbar disk herniation from March 2006 to March 2011 using three different surgical techniques (laminectomy, microscopically assisted percutaneous nucleotomy, and spinous process osteotomy) by using Japanese Orthopaedic Association (JOA) Back Pain Evaluation Questionnaire, Resumption of Activities of Daily Living scale and changes of visual analog scale (VAS) for low back pain and radicular pain. Our study questionnaire addressed patient subjective satisfaction with the operation, residual complaints, and job resumption. Data were analyzed with SPSS version 16.0 (SPSS, Inc., Chicago, Illinois, United States). Statistical significance was set at 0.05. For statistical analysis, chi-square test, Mann-Whitney U test, Kruskal-Wallis test, and repeated measure analysis were performed. For determining the confounding factors, univariate analysis by chi-square test was used and followed by logistic regression analysis.

Results

Ninety-four percent of our patients were satisfied with the results of their surgeries. VAS documented an overall 93.3% success rate for reduction of radicular pain. Laminectomy resulted in better outcome in terms of JOA Back Pain Evaluation Questionnaire. The outcome of surgery did not significantly differ by age, sex, level of education, preoperative VAS for back, preoperative VAS for radicular pain, return to previous job, or level of herniation.

Conclusion

Surgery for lumbar disk herniation is effective in reducing radicular pain (93.4%). All three surgical approaches resulted in significant decrease in preoperative radicular pain and low back pain, but intergroup variation in the outcome was not achieved. As indicated by JOA Back Pain Evaluation Questionnaire–Low Back Pain (JOABPQ-LBP) and lumbar function functional scores, laminectomy achieved significantly better outcome compared with other methods. It is worth mentioning that relief of radicular pain was associated with subjective satisfaction with the surgery among our study population. Predictive factors for ineffective surgical treatment for lumbar disk herniation were female sex and negative preoperative straight leg raising. Age, level of education, and preoperative VAS for low back pain were other factors that showed prediction power.

Keywords

lumbar disk herniation surgery outcome predictors

Introduction

Back pain has been described in the Bible and the writing of Hippocrates and continues to be a major health problem.1 The international prevalence of low back pain vaires,² but estimations for lifetime prevalence of this condition have been reported between 49 and 80%.³ Considering these rates, low back pain is a prevalent condition that has many direct and indirect costs in terms of pain and disability as well as the economic burden in terms of lost work days, health care interventions, and lost productivity time.³,⁴,⁵,⁶,⁷ Herniated lumbar disk is the most common specific cause of low back pain.⁸ Young and middle-aged individuals are the most frequent sufferers of this condition.⁹ Except for cases that require immediate surgical intervention, the first-line treatment involves medical choices. Ninety percent of attacks of sciatica respond to conservative management.¹⁰ Indications for surgical intervention include cauda equina syndrome (absolute emergency), morphine-resistant hyperalgesic sciatica, paralyzing sciatica, grade less than 3 for muscle power as indicated by the Medical Research Council (other than toe muscles, where isolated palsy is not an indication for surgery), and residual disabling pain despite 6 to 8 weeks of full medical treatment.¹¹

Surgery results in better outcome for cases with exclusive severe radicular pain in comparison with patients who suffer from moderate low back and leg pain.¹² Health-related quality of life improves after lumbar disk herniation (LDH) surgery.¹³

The cost-effectiveness of LDH surgery is another area of debate. Although surgery has its own financial burden, 2-year health outcomes for operated cases were better than outcomes among conservatively managed cases.¹⁴

Many approaches have evolved since the introduction of the first surgical method for treatment of ruptured intervertebral disk by Mixter and Barr.¹⁵ Results for different surgical techniques used in treatment of LDH have been reported as follows:

Intradiscal procedures¹⁶,¹⁷ have reported success rates of 70 to 80%.

With microscopically assisted procedures, such as microscopically assisted percutaneous nucleotomy (MAPN),¹⁸ immediate postoperative pain relief was reported in 75% of cases.

Endoscopic procedures: in 81.8% of cases, according to the Macnab criteria, overall excellent or good outcomes were achieved,¹⁹ and according to another study,²⁰ 91% reported no leg pain at the time of follow-up examination.

Hemilaminoplasty led to significant improvements in Japanese Orthopaedic Association (JOA) scores and visual analog scale (VAS) for back and leg pain.²¹

With spinous process osteotomy, 83% of patients were satisfied.²²

Standard diskectomy achieves an average recovery rate of 73.56 ± 21.7% as evidenced by JOA score.²³ Another study reported all but 23.4% of the patients were entirely satisfied.²⁴

Long-term comparative studies between surgically and nonsurgically treated cases have demonstrated greater relief of symptoms and improved function for cases that had surgery.²⁵,²⁶,²⁷ Success rates for LDH surgery have been reported between 56 and 90% in studies that evaluated patients from 2 to 32 years.²⁸,²⁹,³⁰,³¹,³²,³³,³⁴,³⁵,³⁶

We aimed to study the following gaps in the literature. (1) Clinical results of spinous process osteotomy for the treatment of LDH is scarce in the literature. (2) Studies comparing clinical outcomes between laminectomy and osteotomy have not been reported. (3) Results of MAPN with open techniques have not been compared.

We sought to study the outcome of surgery for LDH by conducting a comparative study between three different surgical techniques; we aimed to find whether any of these approaches were more efficacious in reducing pain or improving patients’ quality of life. In addition, factors that could predict the outcome of LDH surgery were assessed.

Materials and Methods

This retrospective study was approved by the research and ethics committee of Shiraz University of Medical Sciences (SUMS), in Shiraz, Iran. From March 2006 to March 2011, 650 cases of spine surgery were performed at SUMS. Three hundred cases of LDH surgery were performed because of (1) persistent radicular pain after 8 weeks of medical and physical treatment, (2) episodes of radicular pain recurring for more than 6 months, (3) motor weakness (except dorsiflexion of big toe). In all, 208 cases were included in our study based on our inclusion criterion of single-level, unilateral LDH. Cases were excluded because of (1) previous history of spine surgery except recurrent cases where their primary surgery was done during the conduction period of this study (e.g., history of spondylolisthesis, spondylolysis, fractures, spinal stenosis, tumors); (2) coexistent pathology except focal stenosis at the level of LDH (e.g., spondylolisthesis, spondylolysis, spinal stenosis, juxtafacet cyst, any intradural pathology). We could not obtain follow-up data on 54 patients despite extensive attempts. Two had died (causes were unrelated to surgery: one had myocardial infarction 2 years postoperation and one had a car accident). We were left with 148 patients who were invited by phone to electively come for a follow-up visit as a part of a research study. They were informed about the nature of the study and its aims. Verbal consent was obtained. Patients were assessed by: (1) pre- and postoperative VAS for back and radicular pain; (2) Resumption of Activities of Daily Living (RADL) scale,³⁷ standardized Persian version; (3) Japanese Orthopedic Association Back Pain Evaluation Questionnaire (JOABPEQ)³⁸; and (4) a study-specific question that addressed patients’ subjective satisfaction with the operation, residual complaints, and job resumption.

Some authors define recurrence as development of radicular pain after a symptom-free period, such as 6 months,³⁹ but in our series, we defined recurrence as lower extremity radicular pain 2 months after the surgery that was confirmed by contrast-enhanced magnetic resonance imaging (MRI). We defined failed surgery as symptoms continuing immediately after operation.

Surgical Methods

Laminectomy (74 cases, 48.6%) was performed by bilateral dissection of the paravertebral muscles, partial (one-third to one-half of the lamina's height) laminectomy of the upper and lower laminas, plus flavectomy and facet-saving, disk fragment removal, and unilateral diskectomy.

MAPN (20 cases, 13.2%) was performed with a percutaneous transmuscular approach.¹⁸ A tube for the surgical corridor was used, and partial flavectomy and removal of the upper lamina edge were done. Disk fragments that were seen inside the disk space were unilaterally removed.

Muscle-sparing technique (Fraser)⁴⁰ or spinous process osteotomy (54 cases, 35.8%) was performed by unilateral dissection of the paravertebral muscles, osteotomy of the upper and lower spinous processes, flavectomy, laminectomy of one-third to one-half of the upper and lower laminas, along with unilateral fragmentectomy and removal of loose disk fragments.

Diskectomy was performed as fragmentectomy, and all loose or severely degenerated disk particles that were found inside the disk space were removed.

The choice of surgical technique was based on the surgeon and patient preferences.

Data Analysis

Data were analyzed with SPSS version 16.0 (SPSS, Inc., Chicago, Illinois, United States). Statistical significance was set at 0.05. Qualitative comparisons between groups were done with the chi-square test. Qualitative variables (that had two options) and quantitative variables (because they did not demonstrate a normal distribution as determined by Kolmogorov-Smirnov test) were compared by nonparametric test (the Mann-Whitney U test). Qualitative variables (that had more than two options) and quantitative variables were compared with the Kruskal-Wallis test. Repeated-measure analysis was performed for comparing pre- and postoperative change in VAS (ΔVAS) for surgical techniques (within and between groups). Variables studied for possible predictive significance are shown in Table 1. To determine the confounding factors, univariate analysis by the chi-square test was used (variables with p ≤ 0.25 were considered in logistic regression analysis) by performing logistic regression model; it seemed that sex was a confounding factor in comparison with other variables.

Table 1

Description of outcome predictor variables

Variable	Description
Age	Years
Sex	Female/male
Workload	Sedentary/light/heavy
Level of education	Illiterate, ability to read and write, high school graduate, bachelor, master, doctorate degree
Duration of symptoms prior to operation	1 mo, 1–6 mo, 6–12 mo, 12 mo
Preoperative hypesthesia	Yes/no
Preoperative SLR	+/−
Preoperative VAS for radicular pain	0–10
Preoperative VAS for low back pain	0–10
Level of disk herniation	L1–L2/L2–L3/L3–L4/L4–L5/L5–S1
Type of disk herniation	Protrusion, subligamentous, extruded, sequestered

Abbreviations: SLR, straight leg raising; VAS, visual analog scale.

Results

Mean follow-up time of our study was 35.54 ± 15.60 months (minimum 12 months). Mean preoperative VAS for radicular pain and low back pain were 9.12 ± 1.87 (standard deviation [SD]) and 6.69 ± 4.31 SD, respectively. Mean preoperative VAS for back pain was higher in women than men (female = 7.26 ± 4.03 SD, male = 6.03 ± 4.54 SD, p = 0.125). However, the difference was not present on preoperative VAS for radicular pain (female = 9.09, male = 9.07, p = 0.35). Other patient data are shown in Table 2.

Table 2

Patient data

Sociodemographic characteristics
Mean age at the time of surgery, y ± SD (range)	46.16 ± 10.35 (24–72)
Sex, n (%)
Females	72 (48)
Males	76 (51.3)
Sex distribution for different surgical methods (%), females, males
Laminectomy	45.2, 54.8
Osteotomy	53.7, 46.3
MAPN	45, 55
Workload (%)
Sedentary jobs (students, office job, drivers)	35.1
Light work with some level of activity (housewives, teachers)	50
Heavy jobs (surgeons, nurses, farmers, construction engineers, workers)	14.9
Level of education (%)
Illiterate	4.6
Able to read and write	25.8
High school graduate	34.4
Bachelor degree	25.2
Master degree	8.6
Doctorate degree	1.3
Preoperative symptoms and duration
Duration from onset of symptoms to time of surgery (mo)
<1 (%)	36
1–6 (%)	44.7
6–12 (%)	14.7
>12 (%)	4.7
Preoperative symptomatology
Radicular pain (%)	97.4
Low back pain (%)	69.5
Lower extremity numbness (%)	57.6
Preoperative physical examination findings
Preoperative SLR status (%)
SLR+ (30–70 degrees)	88.7
SLR− (30–70 degrees)	11.3
Upper LDH preoperative SLR status (n)
SLR+ (30–70 degrees)	18
SLR− (30–70 degrees)	5
Preoperative muscle power (based on Medical Research Council) by manual testing, n (%)
4 or 5/5	134 (88.1)
1–4/5	13 (8.5)
0/5	5 (3.2)
Preoperative hypoesthesia (%)
Positive	75
Negative	25
Surgical findings
Level of disk herniation, n (%)
L1–L2	2 (1.3)
L2–L3	5 (3.2)
L3–L4	16 (10.5)
L4–L5	78 (51.3)
L5–S1	51 (33.5)
Coexistent pathology (n)
Focal stenosis at the level of herniation	10
Ossifying disk	2
S1 lumbarization	2
Limbus fracture	1
Conjoined L5–S1 root	1
S1 spina bifida	1
Type of disk herniation (according to Macnab classification) (%)
Protrusion	25
Subligamentous	25
Extruded	25
Sequestered	25

Abbreviations: LDH, lumbar disk herniation; MAPN, microscopically assisted percutaneous nucleotomy; SD, standard deviation; SLR, straight leg raising.

Hospital Stay

A significant correlation (p = 0.001) was seen between duration of hospital stay and surgical approach. The majority of our cases were discharged 24 to 48 hours after the operation. Hospital stays are shown in Table 3.

Table 3

Duration of hospital stay

	<24 h (%)	24–48 h (%)	>48 h (%)
Laminectomy	0	78.1	21.9
Osteotomy	0	79.6	20.4
MAPN	20	70	10

Abbreviation: MAPN, microscopically assisted percutaneous nucleotomy.

Overall Success Rate for Surgery

Overall success rates for LDH surgery as assessed by patient satisfaction with the surgery, ΔVAS for low back pain and radicular pain, RADL, and JOABPEQ are shown in Table 4. As demonstrated in Table 4, success with regard to patient subjective satisfaction with the operation (94%) is almost equal to the success rate with radicular pain, which suggests that the most troublesome symptom for the patient was the radicular pain and its relief brought about satisfaction.

Table 4

Overall success rate for LDH surgery

Outcome tool	Mean score (%)	Success rate (%)
Patient subjective satisfaction with the surgery (%)	75.5	94
ΔVAS for radicular pain (± SD)	7.70 ± 2.71	93.4
ΔVAS for back pain	4.92 ± 4.36	70.4
RADL	78.63 ± 21.25	69.1
JOABPEQ LBP	53.57 ± 31.29	42.8
JOABPEQ LF	58.16 ± 35.34	43.4
JOABPEQ WA	68.37 ± 30.31	55.3
JOABPEQ SLF	57.91 ± 27.01	36.8
JOABPEQ MH	54.59 ± 19.69	23

Abbreviations: JOABPEQ, Japanese Orthopedic Association Back Pain Evaluation Questionnaire; LBP, low back pain; LDH, lumbar disk herniation; LF, lumbar function; MH, mental health; RADL, Resumption of Activities of Daily Living scale; SD, standard deviation; SLF, social life function; VAS, visual analog scale; WA, walking ability.

Surgical Complications

Surgical complications were classified into three categories: intraoperative, immediate postoperative, and late. We had a 5.9% complication rate for durotomies. A statistically significant relation (p = 0.007) was found between complications and surgical techniques. Dural tears were reported in one case of laminectomy and four cases operated on with osteotomy and MAPN. Except for one case with evident cerebrospinal fluid leak, in others pinpoint dural tears were sutured with muscle patch and covered with gel foam. One patient developed postoperative chin blister.

Cases with Recurrence

To find out the true rate of recurrence in this study, we excluded cases whose first operation was done before March 2006 and whose revision surgeries were performed during the period of this study. Three patients experienced recurrence (1.98%). The minimum time from primary surgery to revision surgery was 70 days. Two had ipsilateral same-level and one had contralateral different-level recurrences. One of our recurrent cases underwent two revision surgeries. Two had MAPN as their primary surgery. For revision surgeries, laminectomy was done for two. The patient who required two revision surgeries was a 31-year-old man at the time of the primary surgery; the first revision surgery was osteotomy and the second was decompression, fixation, and interbody fusion. Outcome of revision surgeries was assessed by ΔVAS (for back radicular pain) and patient subjective satisfaction with the surgery. We could not use the JOABPEQ and the RADL scale for evaluating the outcome of revision surgeries because one patient underwent revision surgery 70 days after the primary surgery; in those 70 days, the patient was modestly active and had not completely returned to normal activities. Baseline data and outcome of revision surgeries are as follows: mean preoperative VAS for leg pain (±SD) was 9.33 ± 1.15, mean preoperative VAS for back pain (±SD) was 4.66 ± 1.15, mean postoperative VAS for leg pain (±SD) was 2.66 ± 1.15, mean postoperative VAS for back pain (±SD) was 0.66 ± 1.15, mean ΔVAS for leg pain (±SD) was 6.66 ± 2.30, and mean ΔVAS for back pain (±SD) was 4 ± 2. A 100% success rate was achieved for radicular pain according to ΔVAS, and a 66.7% success rate was achieved for back pain as indicated by ΔVAS and subjective satisfaction with the operation.

Precipitating factors like lifting heavy objects and doing heavy exercises were identified in two patients. Of the nine patients suspected of having recurrence, contrast-enhanced MRI revealed adjacent-level disease in three. Medical treatment and strengthening exercises for abdominal and paravertebral muscles were recommended. No statistical significance was achieved between level of herniation, intraoperative complications (durotomy), and recurrence.

Foot Drop Cases

Foot drop is defined as a decrease in ankle dorsiflexion power to 0 to 3/5 (according to Medical Research Council Classification) evaluated by manual testing. There were four cases of foot drop. Three were men and one was a woman. The youngest was 46 years old and the oldest was sixty-six years at the time of operation. Preoperative complaints were back pain, radicular pain, numbness, and inability to walk. Disks involved were at the level of L3–L4, L4–L5 (two cases), and L5–S1. Duration between the symptom of “being unable to walk because of ankle joint weakness” to the time of surgery for two patients was less than 1 month and for two others was between 1 and 6 months. All cases had positive straight leg raising (SLR). Two individuals achieved recovery with surgical decompression. One was a 66-year-old man with L3–L4 disk herniation, with bilateral muscle power for ankle dorsiflexion of 0/5. Laminectomy was performed less than 1 month after the onset of weakness, and his ankle dorsiflexion muscle weakness recovered to 4/5. The second patient was a 46-year-old woman with L3–L4 LDH who had preoperative muscle power of 2/5. She underwent lumbar diskectomy (muscle-sparing technique) within 1 month of onset of weakness and regained her power (4/5) by the first follow-up in 2 months.

Recovery of Symptoms

For 105, 145, and 86 cases, preoperative low back pain, radicular pain, and hypoesthesia were documented, respectively. Rates of recovery (symptom-free individuals) for these symptoms were achieved in 54 (51.4%) of low back pain cases, 102 (70.34%) of radicular pain cases, and 58 (67.44%) with hypoesthesia.

Residual Complaints

We found an overall rate of 71.1% for residual complaints of back and radicular pain and various sensory complaints alone or in combination. Subjectively, the severity of these symptoms did not impair return of these patients to their previous jobs. There was a direct, significant relation between the severity of back pain and leg pain (r = 0.509, p = 0.001), which means those with more intense residual back pain reported more severe residual leg pain. A significant correlation (p = 0.016) was present between surgical techniques and residual symptoms. Among individuals with residual complaints, 48.1% were operated on by laminectomy, and 39 and 12.7% of individuals who reported residual complaints underwent osteotomy and MAPN, respectively. No association was present between preoperative hypoesthesia, type of disk herniation, age, sex, preoperative VAS score for back/radicular pain, duration of symptoms from the onset to the time of surgery, job, preoperative symptoms, level of herniation, or durotomy and residual complaints. Although some patients did not have access to physiotherapy or aqua therapy, 18 and 13 cases who complained of residual back and radicular pain, respectively, did not benefit from these measures when compared with those who had similar complaints but did not use physiotherapy. Fifteen cases with negative preoperative back pain reported back pain in follow-up visits. Most sufferers (nine cases) were operated by osteotomy (mean VAS for back pain: 4.93, mean age: 45). A significant relation (p = 0.001) was present between presence and severity of residual symptoms and JOABPEQ mental health functional score. Individuals with lower scores reported higher degrees of back pain, radicular pain, and lower extremity numbness. Table 5 demonstrates additional data regarding residual complaints.

Table 5

Residual complaints

Residual complaints
Low back pain (%)	34.4
Radicular pain (%)	28.9
Mean VAS for residual low back pain (0–10)	5.12
Mean VAS for residual radicular pain (0–10)	4.16
Residual sensory complaints (numbness, muscular spasm, burning sensation) (%)
Only sensory	18.4
Sensory + low back pain	8.6
Sensory + radicular pain	2
Sensory + low back pain + radicular pain	3.9
Females with residual complaints (%)	34.7
Males with residual complaints (%)	29.8
Females with residual low back pain (%)	57.6
Males with residual low back pain (%)	42.4

Abbreviation: VAS, visual analog scale.

Results in Elderly Cases

Sixteen cases were above 60 years of age. No significant statistical difference was achieved when we compared outcome of surgery between individuals older versus younger than 60 years of age. Twelve cases had negative SLR. No association was present between the type of herniation and age over 60 years.

Upper LDH Cases

With no statistical significance, surgery for upper LDH cases (L1–L2, L2–L3, and L3–L4) yielded better results when compared with L4–L5 and L5–S1. Of 23 cases with L1–L2, L2–L3, and L3–L4 disk herniation, none had coexisting pathologies. No correlation was demonstrated between upper LDH and workload. There was a significant statistical relation between age and three upper LDH (p = 0.001). The mean age for cases with L1–L2, L2–L3, and L3–L4 disk herniation was 57.50 ± 4.03 SD and 52.43 ± 11.01 SD, respectively (in comparison with L4–L5 with mean age of 46 and compared with L5–S1 cases with mean age of 42). This finding suggests that lower lumbar disks are more vulnerable to mechanical loads, which make them more susceptible to herniation about a decade earlier than upper LDH.

Mental Health

To determine the influence of mental status on outcome, the relation between JOABPEQ mental health functional score and other outcome instruments was studied. Results showed that subjective satisfaction with the surgery (p = 0.001), four JOABPEQ functional scores (p = 0.001 for low back pain, lumbar function, walking ability, and social life function), and RADL scores (p = 0.001) were poorer in cases that had less satisfying JOABPEQ mental health functional score, a finding that draws attention to the influence of psychological status on other outcome measures.

Type of Disk Herniation

Patients with protrusion-type herniation had lower (poorer) outcome by means of JOABPEQ low back pain functional score (p = 0.046). Extruded-type herniation cases showed statistically significant higher (better) score (p = 0.052) for JOABPEQ low back pain functional score. Other than the aforementioned results, no statistically significant relation was found between type of disk herniation and our outcome instruments.

Pregnancy

With each pregnancy, JOABPEQ low back pain functional score decreased by 0.228 points (p = 0.052). No relation existed between number of pregnancies and type of LDH.

Return to Job

Ninety-four percent of our subjects resumed their jobs.

Results of Surgical Techniques

All three surgical approaches resulted in a significant decrease (p = 0.001) in the intensity of preoperative radicular pain and low back pain, but intergroup variations in the outcome with regards to the aforementioned outcome tools were not achieved. As indicated by JOABPEQ low back pain and lumbar function functional scores, laminectomy achieved significantly (p = 0.001) better outcomes in comparison with other methods. Comparisons between different surgical techniques in terms of outcome tools scores and success rates are shown in Tables 6, 7, and 8. Outcome of surgery did not significantly differ by age, sex, level of education, preoperative VAS for back pain, preoperative VAS for radicular pain, return to previous job, or level of herniation.

Table 6

Outcome measures scores and success rate for individual surgical technique

Outcome tool score	Laminectomy	Osteotomy	MAPN	p Value
Mean ΔVAS for radicular pain ± SD (% successful)	7.83 ± 2.57 (94.5)	7.83 ± 2.42 (96.3)	6.90 ± 3.50 (84)	See Table 7
Mean ΔVAS for LBP ± SD (% successful)	5.54 ± 4.34 (76.7)	4.40 ± 4.48 (66.7)	4.10 ± 4.02 (60)	See Table 8
Mean RADL ± SD (% successful)	81.46 ± 20.10 (75.3)	76.45 ± 21.99 (61.1)	74.25 ± 22.44 (65)	0.105
Patient subjective satisfaction with the surgery (%)	79.5 (79.5)	74.1 (74.1)	60 (60)	0.939
Mean JOABPEQ LBP ± SD (% successful)	63.99 ± 31.50 (63)	45.76 ± 26.23 (22.2)	40.71 ± 30.84 (25)	0.001
Mean JOABPEQ LF ± SD (% successful)	69.63 ± 33.14 (60.3)	49.84 ± 33.31 (27.8)	42.5 ± 37.55 (30)	0.001
Mean JOABPEQ WA ± SD (% successful)	77 ± 24.49 (64.4)	60.05 ± 33.20 (46.3)	57.85 ± 34.52 (45)	0.099
Mean JOABPEQ SLF ± SD (% successful)	63.34 ± 22.89 (42.5)	51.75 ± 30.18 (29.6)	53.91 ± 29.28 (35)	0.359
Mean JOABPEQ MH ± SD (% successful)	55.11 ± 18.52 (21.9)	56.52 ± 20.79 (7.8)	50.72 ± 21.08 (20)	0.662

Abbreviations: JOABPEQ, Japanese Orthopedic Association Back Pain Evaluation Questionnaire; LBP, low back pain; LF, lumbar function; MAPB, microscopically assisted percutaneous nucleotomy; MH, mental health; RADL, Resumption of Activities of Daily Living scale; SD, standard deviation; SLF, social life function; VAS, visual analog scale; WA, walking ability.

Table 7

VAS for radicular pain (comparison between and within surgical techniques)

Surgical method	Preoperative radicular pain VAS (mean)	Postoperative radicular pain VAS (mean)	Mean ΔVAS (radicular pain)	p Value for ΔVAS for radicular pain (within group)	p Value for ΔVAS for radicular pain (between group)
Laminectomy (±SD)	9.2297 ± 1.86934	1.3919 ± 2.07277	7.83 ± 2.57	0.001	0.345
Osteotomy (±SD)	9.0741 ± 1.63513	1.2407 ± 1.70388	7.83 ± 2.42	0.001	0.345
MAPN (±SD)	8.9000 ± 2.46875	2.0000 ± 2.49209	6.90 ± 3.50	0.001	0.345

Abbreviations: MAPN, microscopically assisted percutaneous nucleotomy; SD, standard deviation; VAS, visual analog scale.

Table 8

VAS for back pain (comparison between and within surgical techniques)

Surgical method	Preoperative back pain VAS (mean)	Postoperative back pain VAS (mean)	Mean ΔVAS (back pain)	p Value for ΔVAS for back pain (within group)	p Value for ΔVAS for back pain (between group)
Laminectomy (±SD)	7.2297 ± 4.10995	1.6486 ± 2.17352	5.54 ± 4.34	0.001	0.209
Osteotomy (±SD)	6.0741 ± 4.51351	1.6667 ± 2.15442	4.40 ± 4.48	0.001	0.209
MAPN (±SD)	6.4000 ± 4.47684	2.3000 ± 2.73573	4.10 ± 4.02	0.001	0.209

Abbreviations: MAPN, microscopically assisted percutaneous nucleotomy; SD, standard deviation; VAS, visual analog scale.

Factors Predictive of Outcome

The second part of our study was aimed to determine predictive factors in outcome of LDH surgery. A description of the variables is given in Table 1. As demonstrated in Table 9, predictive factors for ineffective surgical treatment for LDH were female sex and negative preoperative SLR. Female sex compared with male sex had two to four times more risk of unsuccessful results, whereas positive preoperative SLR was a predictor for successful treatment. Age, level of education, and preoperative VAS for low back pain were other factors that showed prediction power. The risk of unsuccessful surgical treatment was shown to increases with age. Other factors associated with ineffective surgical management were lower educational level and higher scores for preoperative VAS for low back pain.

Table 9

Significant outcome predictors

Factor	Outcome tool	Percentage correct	p Value	OR	95% CI
Sex (female/male)	JOABPEQ LF	68.1	0.013	2.933	1.252–6.872
Sex (female/male)	JOABPEQ MH	80.9	0.008	3.983	1.434–11.061
Sex (female/male)	JOABPEQ SLF	68.1	0.016	2.752	1.207–6.276
Preoperative SLR (+/−)	RADL	76.6	0.014	0.179	0.045–0.705
Age	JOABPEQ MH	80.9	0.033	1.060	1.005–1.119
Level of education	JOABPEQ MH	80.9	0.030	2.074	1.072–4.014
Preoperative VAS for low back pain	JOABPEQ SLF	68.1	0.038	0.908	0.829–0.995
Preoperative VAS for low back pain	ΔVAS for back pain	97.2	0.002	3.648	1.588–8.382

Abbreviations: CI, confidence interval; JOABPEQ, Japanese Orthopedic Association Back Pain Evaluation Questionnaire; LF, lumbar function; MH, mental health; OR, odds ratio; RADL, Resumption of Activities of Daily Living scale; SLF, social life function; SLR, straight leg raising; VAS, visual analog scale.

Discussion

Outcome

There have been several studies on the long-term outcome of LDH surgery.²⁶,²⁹,³²,³³,³⁵,⁴¹,⁴²,⁴³ Few studies have addressed the results of LDH surgery in Iran.⁴⁴,⁴⁵ To the best of our knowledge, this is the first study among the Iranian population about the outcome of different surgical techniques and the effect of various factors on the results.

The success rate for LDH surgery despite various outcome measures has been reported to be 56 to 90%.²⁸,³⁰,³²,⁴¹,⁴⁶,⁴⁷,⁴⁸ The recurrence rate in our study was 2.6%, which is lower than the rates reported in the literature (7.1 to 12.7%).⁴⁹,⁵⁰,⁵¹,⁵²,⁵³

The rate of residual postoperative complaints in our study population was 71.1%. Residual back pain occurred in 43.3% of cases, which was higher than one study that reported a 17% rate for backache at the time of follow-up.⁵⁴ Naylor in a study conducted on 204 cases of laminectomy reported 32 patients with postoperative lower extremity numbness, cramps, and paraesthesia.⁵⁴ In that study, 15.68% of cases had postoperative sensory deficits, which is less than our rate for the group with only sensory complaints (18.4%). Also in that study, 5 of 32 cases with sensory symptoms were in the backache group. We had 13 patients (8.6%) who reported sensory deficits and back pain together. Different causes of back pain following LDH surgery have been proposed.⁵⁵ Although Ostelo et al evaluated residual complaints at 3- and 12-month follow-up, they demonstrated that baseline back and leg pain predicted residual back and leg pain.⁵⁶ In our series, we did not note this relation.

Although we did not find a relationship between type of herniation and postoperative residual back pain, we found that cases with extruded-type disk herniation had better JOABPEQ low back pain functional score. Another study reported that the degree of low back pain was relatively lower for extruded cases as compared with that for protruded or sequestered cases.⁵⁷

Recovery of foot drop has been documented in some literature.⁵⁸,⁵⁹,⁶⁰,⁶¹ Ghahreman et al suggested that severity of motor deficit prior to surgery and the age of the patient were important prognostic predictors of the recovery of ankle dorsiflexion weakness.⁵⁸ Girardi et al found no statistically significant relation between extent of recovery and age, diagnosis (herniated nucleus pulpous, lumbar canal stenosis), or severity of preoperative weakness.⁵⁹ The severity of preoperative weakness has been found to be an important prognostic factor in two studies.⁶⁰,⁶¹ Although Ghahreman et al found no relation between duration and outcome,⁵⁸ other studies noted the importance of preoperative symptom duration as a factor in recovery of foot drop.⁶⁰,⁶¹ We had a small study population of four foot drop cases, but we could not find any relation between preoperative duration of weakness, preoperative weakness severity, or age and recovery.

In our series, 23 cases with upper LDH were identified. Sanderson et al concluded that surgical outcome in terms of postoperative back and radicular pain was worse for herniated disks at L1–L2 and L2–L3 compared with those at L3–L4.⁶² Our results do not support the previously mentioned result. None of our cases had coexisting or preexisting pathologies in upper LDH, a finding that is not in agreement with another study.⁶³ The mean age for this kind of disk involvement in our study (53 years) is slightly higher than other studies (40.7 and 50 years).⁶³,⁶⁴ Gutterman and Shenkin reported that 78% of their cases had satisfactory relief of pain.⁶⁵ Satisfactory operative results were achieved in 90% of patients in a study conducted by Wei et al.⁶⁶ Seventy-eight percent (18/23) of our patients having upper LDH were completely satisfied with their surgery.

Fujii et al suggested that outcome of lumbar diskectomy in elderly patients was as good as in younger patients.⁶⁷ Our findings are in line with this study by Fujii et al.

Although one study found that sequestered-type herniation was more common in elderly patients,⁶⁷ we did not find a relationship between age and type of herniation. Our findings agree to some extent with those of Jönsson and Strömqvist,⁶⁸,⁶⁹ who reported that with increasing age there was a decreasing prevalence of highly restricted positive SLR test results, and the prevalence of severe reduction of walking capacity increased.

Dural tear incidence has been reported to be 2.7% for LDH surgery⁷⁰ and 3.2% for spine surgery.⁷¹ In our series, we encountered a 5.9% rate of incidental durotomies. It has been suggested that durotomy predicts poor outcome of surgery.⁷¹ In our series, cases with durotomy demonstrated poorer outcome as indicated by JOABPEQ walking ability functional score (p = 0.001).

Predictors

One study demonstrated longer duration for preoperative sensory deficits among predictors of poor outcome.⁷² In our study, preoperative hypoesthesia did not show sufficient statistical power to be included in the analysis of predictive factors.

Effect of age on outcome of LDH surgery has been reported to be a statistically significant short-term predictor,⁷³ but Graver et al, who had 7-year clinical follow-up, suggested that age had no statistically significant prognostic value.³² We found that risk of unsuccessful surgical treatment increased with age.

Den Boer et al found that lower level of education was a predictor of unfavorable outcome.⁷⁴ Oslon et al found that surgical outcomes did not differ by level of education.⁷⁵ However, in our series, we found higher educational level to be a predictor of success.

Several studies have reported that depression and psychological condition of patients undergoing LDH surgery play a role in the outcome.⁴⁷,⁷⁴,⁷⁶,⁷⁷,⁷⁸,⁷⁹,⁸⁰,⁸¹,⁸²,⁸³ Edwards et al⁷⁶ found that distress and anxiety had a negative effect on pain and function. Den Boer et al supported the relation between unfavorable outcome and psychological complaints.⁷⁴ Arpino et al⁸¹ also demonstrated a negative prognostic effect of depression. Our finding by means of JOABPEQ mental health functional score is consistent with previous studies and confirms that psychological status is important in outcome evaluation studies for LDH surgery. Studies addressing results of LDH surgery should encompass the psychological status of individuals as well.

Duration of preoperative radicular pain has been suggested to influence the outcome of LDH surgery in several studies.⁴⁶,⁷²,⁷³,⁸⁴,⁸⁵,⁸⁶,⁸⁷,⁸⁸ Ng et al⁸⁹ found less favorable outcome in patients with duration of leg pain more than 12 months. Rothoerl et al⁷² found duration of leg pain more than 60 days to be among negative outcome predictors. Duration of pain in our study did not attain the statistical qualification to be included in the logistic regression analysis, but with no statistically significant relation, we found preoperative pain duration of 6 to 12 months yielded satisfactory results compared with durations of less than 1 month, 1 to 6 months, and more than 12 months.

In our series, female sex was associated with unsuccessful clinical outcome. Peul et al suggested that female sex was a strong predictor of unsatisfactory outcome at 1 year for patients with sciatica.⁹⁰ Strömqvist et al also found that at 1-year follow-up, females reported a higher rate of consumption of analgesics, a higher degree of postoperative back and leg pain, and less improvement regarding disability and some aspects of quality of life.⁶⁹ Although the previously mentioned study reported patient outcome at 1-year follow-up, we also found a higher rate for females with residual back pain (female = 57.6%, male = 42.4%). Sex was not a statistically significant predictor for outcome in one short-term study,⁷³ but was reported to have a minor influence on the 1-year outcome in another short-term study.³²

Loupasis et al did not suggest a relationship between poorer results and the level of surgery.³³ Generally, our findings are in line with Loupasis et al.³³

We found positive preoperative SLR to be a predictor for success in the outcome of surgical management for LDH. Kohlboeck et al found Lasegue sign to be a high risk factor for poor outcome.⁴⁷ Moranjkic et al reported that preoperative tension sign was not a statistically significant predictor of short-term outcome.⁷³ Positive SLR association with poor outcome was demonstrated by Vroomen et al.⁹¹

Hurme and Alaranta evaluated patients at 1 and 6 months postoperatively and reported that the operative finding of protrusion predicted a poor result.⁸⁵ Moranjkic et al⁷³ found that extrusion-type disk implied better outcome. Folman et al⁸⁷ reported better outcome for noncontained herniation as compared with contained herniation. Although type of disk herniation in our study did not show a predictive power, we found significantly poorer results for protrusion-type herniation in JOABPEQ low back pain functional score, and extruded-type herniation cases showed statistically significant higher score by means of JOABPEQ low back pain functional score.

To the best of our knowledge, severity of preoperative low back pain has not been reported as an outcome predictor. As indicated by two of our outcome instruments, higher preoperative VAS for low back pain was a risk factor for not achieving success with surgical management of LDH.

Conclusion

Surgery for LDH is an effective treatment in terms of reducing radicular pain (93.4%). All three surgical approaches resulted in significant decrease in the intensity of preoperative radicular pain and low back pain, but intergroup variations in the outcome were not achieved. As indicated by JOABPEQ low back pain and lumbar function functional scores, laminectomy achieved significantly better outcomes compared with other methods. Relief of radicular pain was associated with subjective satisfaction with the surgery among our study population, as evidenced by the decrease in radicular pain and the subjective satisfaction with the operation. Factors associated with poor success in our surgeries were female sex, negative preoperative SLR, age, and level of education.

Disclosures

Mahsa Sedighi, none

Ali Haghnegahdar, Board membership: Iranian Board of Neurosurgery; Consultant: Shiraz University of Medical Sciences

Footnotes

Acknowledgment

We deeply appreciate Mohsen Akparpour (SUMS) for his efforts in performing the statistical analysis of this study and also Esmaeil Ghaedsharaf (SUMS) for his guidance on some of the digital aspects related to this work.

References

Simeone

Herkowitz

H N

Garfin

S R

, et al.

The Spine

Philadelphia

W.B. Saunders

1992

Manek

N J

MacGregor

A J

Epidemiology of back disorders: prevalence, risk factors, and prognosis

Curr Opin Rheumatol 2005 17 2 134–140

Maniadakis

Gray

The economic burden of back pain in the UK

Pain 2000 84 1 95–103

Maetzel

The economic burden of low back pain: a review of studies published between 1996 and 2001

Best Pract Res Clin Rheumatol 2002 16 1 23–30

Katz

J N

Lumbar disc disorders and low-back pain: socioeconomic factors and consequences

J Bone Joint Surg Am 2006 88 02 21–24

Hoy

Brooks

Blyth

Buchbinder

The Epidemiology of low back pain

Best Pract Res Clin Rheumatol 2010 24 6 769–781

Dagenais

Caro

Haldeman

A systematic review of low back pain cost of illness studies in the United States and internationally

Spine J 2008 8 1 8–20

Hansson

The cost-utility of lumbar disc herniation surgery

Eur Spine J 2007 16 3 329–337

Schoenfeld

A J

Weiner

B K

Treatment of lumbar disc herniation: Evidence-based practice

Int J Gen Med 2010 3 209–214

10.

Gibson

J N

Waddell

Surgical interventions for lumbar disc prolapse: updated Cochrane Review

Spine (Phila Pa 1976) 2007 32 16 1735–1747

11.

Blamoutier

Surgical discectomy for lumbar disc herniation: surgical techniques

Orthop Traumatol Surg Res 2013 99 (1, Suppl) S187–S196

12.

Postacchini

Management of herniation of the lumbar disc

J Bone Joint Surg Br 1999 81 4 567–576

13.

Kagaya

Takahashi

Sugawara

Kuroda

Takahama

Quality of life assessment before and after lumbar disc surgery

J Orthop Sci 2005 10 5 486–489

14.

Tosteson

A N

Skinner

J S

Tosteson

T D

, et al.

The cost effectiveness of surgical versus nonoperative treatment for lumbar disc herniation over two years: evidence from the Spine Patient Outcomes Research Trial (SPORT)

Spine (Phila Pa 1976) 2008 33 19 2108–2115

15.

Mixter

W J

Barr

J S

Rupture of the intervertebral disc with involvement of the spinal canal

N Engl J Med 1934 211 210–215

16.

Krugluger

Knahr

Minimally invasive disc surgery: a review

Int Orthop 2001 24 6 303–306

17.

Manchikanti

Singh

Falco

F J

, et al.

An updated review of automated percutaneous mechanical lumbar discectomy for the contained herniated lumbar disc

Pain Physician 2013 16 (2, Suppl) SE151–SE184

18.

Greiner-Perth

Böhm

El Saghir

Microscopically assisted percutaneous nucleotomy, an alternative minimally invasive procedure for the operative treatment of lumbar disc herniation: preliminary results

Neurosurg Rev 2002 25 4 225–227

19.

Lübbers

Abuamona

Elsharkawy

A E

Percutaneous endoscopic treatment of foraminal and extraforaminal disc herniation at the L5-S1 level

Acta Neurochir (Wien) 2012 154 10 1789–1795

20.

Wang

Zeng

Nie

, et al.

Percutaneous endoscopic interlaminar discectomy for pediatric lumbar disc herniation

Childs NervSyst 2014 30 5 897–902

21.

Xinyu

Yanping

Jianmin

Liangtai

Hemilaminoplasty for the treatment of lumbar disc herniation

Int Orthop 2009 33 5 1323–1327

22.

Weiner

B K

Fraser

R D

Peterson

Spinous process osteotomies to facilitate lumbar decompressive surgery

Spine (Phila Pa 1976) 1999 24 1 62–66

23.

Yorimitsu

Chiba

Toyama

Hirabayashi

Long-term outcomes of standard discectomy for lumbar disc herniation: a follow-up study of more than 10 years

Spine (Phila Pa 1976) 2001 26 6 652–657

24.

Padua

Romanini

Padua

de Santis

Ten- to 15-year outcome of surgery for lumbar disc herniation: radiographic instability and clinical findings

Eur Spine J 1999 8 1 70–74

25.

Lurie

J D

Tosteson

T D

Tosteson

A NA

, et al.

Surgical versus nonoperative treatment for lumbar disc herniation: eight-year results for the spine patient outcomes research trial

Spine (Phila Pa 1976) 2014 39 1 3–16

26.

Atlas

S J

Keller

R B

Y A

Deyo

R A

Singer

D E

Long-term outcomes of surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: 10 year results from the Maine Lumbar Spine Study

Spine (Phila Pa 1976) 2005 30 8 927–935

27.

Atlas

S J

Keller

R B

Chang

Deyo

R A

Singer

D E

Surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: five-year outcomes from the Maine Lumbar Spine Study

Spine (Phila Pa 1976) 2001 26 10 1179–1187

28.

Salenius

Laurent

L E

Results of operative treatment of lumbar disc herniation. A survey of 886 patients

Acta Orthop Scand 1977 48 6 630–634

29.

Barrios

Ahmed

Arrótegui

Björnsson

Gillström

Microsurgery versus standard removal of the herniated lumbar disc. A 3-year comparison in 150 cases

Acta Orthop Scand 1990 61 5 399–403

30.

Casal-Moro

Castro-Menéndez

Hernández-Blanco

Bravo-Ricoy

J A

Jorge-Barreiro

F J

Long-term outcome after microendoscopic diskectomy for lumbar disk herniation: a prospective clinical study with a 5-year follow-up

Neurosurgery 2011 68 6 1568–1575, discussion 1575

31.

Findlay

G F

Hall

B I

Musa

B S

Oliveira

M D

Fear

S C

A 10-year follow-up of the outcome of lumbar microdiscectomy

Spine (Phila Pa 1976) 1998 23 10 1168–1171

32.

Graver

Haaland

A K

Magnaes

Loeb

Seven-year clinical follow-up after lumbar disc surgery: results and predictors of outcome

Br J Neurosurg 1999 13 2 178–184

33.

Loupasis

G A

Stamos

Katonis

P G

Sapkas

Korres

D S

Hartofilakidis

Seven- to 20-year outcome of lumbar discectomy

Spine (Phila Pa 1976) 1999 24 22 2313–2317

34.

Davis

R A

A long-term outcome analysis of 984 surgically treated herniated lumbar discs

J Neurosurg 1994 80 3 415–421

35.

Mariconda

Galasso

Secondulfo

Rotonda

G D

Milano

Minimum 25-year outcome and functional assessment of lumbar discectomy

Spine (Phila Pa 1976) 2006 31 22 2593–2599, discussion 2600–2601

36.

Soh

J-W

Lee

J C

Goo

H-M

, et al.

Clinical results about more than 5 years follow-up after open discectomy

J Korean Soc Spine Surg 2011 18 3 140–145

37.

Williams

R M

Myers

A M

A new approach to measuring recovery in injured workers with acute low back pain: Resumption of Activities of Daily Living Scale

Phys Ther 1998 78 6 613–623

38.

Fukui

Chiba

Kawakami

, et al; Subcommittee of the Clinical Outcome Committee of the Japanese Orthopaedic Association on Low Back Pain and Cervical Myelopathy Evaluation.

JOA back pain evaluation questionnaire (JOABPEQ)/JOA cervical myelopathy evaluation questionnaire (JOACMEQ) the report on the development of revised versions April 16, 2007

J Orthop Sci 2009 14 3 348–365

39.

Swartz

K R

Trost

G R

Recurrent lumbar disc herniation

Neurosurg Focus 2003 15 3 E10

40.

Fraser

R D

Hall

D J

Laminectomy combined with posterolateral stabilisation: a muscle-sparing approach to the lumbosacral spine

Eur Spine J 1993 1 4 249–253

41.

Ross

Jelsma

Postoperative analysis of 366 consecutive cases of herniated lumbar discs

Am J Surg 1952 84 6 657–662

42.

Jackson

R K

The long-term effects of wide laminectomy for lumbar disc excision. A review of 130 patients

J Bone Joint Surg Br 1971 53 4 609–616

43.

Padua

Romanini

Padua

de Santis

Ten- to 15-year outcome of surgery for lumbar disc herniation: radiographic instability and clinical findings

Eur Spine J 1999 8 1 70–74

44.

Tabatabaie

Early and delayed results of lumbar disc surgery in 314 patients

Med J Islam Repub Iran 1993 7 9–12

45.

Alimohammadi

A review of 3200 cases of herniated lumbar disc

Acta Medica Iranica 1987 29 1–2 45–54

46.

Silverplats

Lind

Zoëga

, et al.

Clinical factors of importance for outcome after lumbar disc herniation surgery: long-term follow-up

Eur Spine J 2010 19 9 1459–1467

47.

Kohlboeck

Greimel

K V

Piotrowski

W P

, et al.

Prognosis of multifactorial outcome in lumbar discectomy: a prospective longitudinal study investigating patients with disc prolapse

Clin J Pain 2004 20 6 455–461

48.

Tullberg

Isacson

Weidenhielm

Does microscopic removal of lumbar disc herniation lead to better results than the standard procedure? Results of a one-year randomized study

Spine (Phila Pa 1976) 1993 18 1 24–27

49.

Kim

M S

Park

K-W

Hwang

, et al.

Recurrence rate of lumbar disc herniation after open discectomy in active young men

Spine (Phila Pa 1976) 2009 34 1 24–29

50.

Morgan-Hough

C VJ

Jones

P W

Eisenstein

S M

Primary and revision lumbar discectomy. A 16-year review from one centre

J Bone Joint Surg Br 2003 85 6 871–874

51.

Cinotti

Roysam

G S

Eisenstein

S M

Postacchini

Ipsilateral recurrent lumbar disc herniation. A prospective, controlled study

J Bone Joint Surg Br 1998 80 5 825–832

52.

Ambrossi

G LG

McGirt

M J

Sciubba

D M

, et al.

Recurrent lumbar disc herniation after single-level lumbar discectomy: incidence and health care cost analysis

Neurosurgery 2009 65 3 574–578, discussion 578

53.

Jensdottir

Gudmundsson

Hannesson

Gudmundsson

20 years follow-up after the first microsurgical lumbar discectomies in Iceland

Acta Neurochir (Wien) 2007 149 1 51–58, discussion 57–58

54.

Naylor

Late results of laminectomy for lumbar disc prolapse. A review after ten to twenty-five years

J Bone Joint Surg Br 1974 56 1 17–29

55.

Häkkinen

Ylinen

Kautiainen

, et al.

Pain, trunk muscle strength, spine mobility and disability following lumbar disc surgery

J Rehabil Med 2003 35 5 236–240

56.

Ostelo

R WJG

Vlaeyen

J WS

van den Brandt

P A

de Vet

H C

Residual complaints following lumbar disc surgery: prognostic indicators of outcome

Pain 2005 114 1–2 177–185

57.

Lee

J C

Kim

M S

Shin

B J

An analysis of the prognostic factors affecting the clinical outcomes of conventional lumbar open discectomy: clinical and radiological prognostic factors

Asian Spine J 2010 4 1 23–31

58.

Ghahreman

Ferch

R D

Rao

Chandran

Shadbolt

Recovery of ankle dorsiflexion weakness following lumbar decompressive surgery

J Clin Neurosci 2009 16 8 1024–1027

59.

Girardi

F P

Cammisa

F P

Huang

R C

Parvataneni

H K

Tsairis

Improvement of preoperative foot drop after lumbar surgery

J Spinal Disord Tech 2002 15 6 490–494

60.

Aono

Iwasaki

Ohwada

, et al.

Surgical outcome of drop foot caused by degenerative lumbar diseases

Spine (Phila Pa 1976) 2007 32 8 E262–E266

61.

Postacchini

Giannicola

Cinotti

Recovery of motor deficits after microdiscectomy for lumbar disc herniation

J Bone Joint Surg Br 2002 84 7 1040–1045

62.

Sanderson

S P

Houten

Errico

Forshaw

Bauman

Cooper

P R

The unique characteristics of “upper” lumbar disc herniations

Neurosurgery 2004 55 2 385–389, discussion 389

63.

Hsu

Zucherman

Shea

, et al.

High lumbar disc degeneration. Incidence and etiology

Spine (Phila Pa 1976) 1990 15 7 679–682

64.

Albert

T J

Balderston

R A

Heller

J G

, et al.

Upper lumbar disc herniations

J Spinal Disord 1993 6 4 351–359

65.

Gutterman

Shenkin

H A

Syndromes associated with protrusion of upper lumbar intervertebral discs. Results of surgery

J Neurosurg 1973 38 4 499–503

66.

Wei

C P

Cheng

W C

Chang

C N

Lee

S T

Lui

T N

Wang

A D

Upper lumbar disc herniation

Changge-ng Yi-xue Zazhi 1989 12 4 193–199

67.

Fujii

Henmi

Kanematsu

Mishiro

Sakai

Surgical treatment of lumbar disc herniation in elderly patients

J Bone Joint Surg Br 2003 85 8 1146–1150

68.

Jönsson

Strömqvist

Influence of age on symptoms and signs in lumbar disc herniation

Eur Spine J 1995 4 4 202–205

69.

Strömqvist

Ahmad

Hildingsson

Jönsson

Strömqvist

Gender differences in lumbar disc herniation surgery

Acta Orthop 2008 79 5 643–649

70.

Strömqvist

Jönsson

Strömqvist

; Swedish Society of Spinal Surgeons.

Dural lesions in lumbar disc herniation surgery: incidence, risk factors, and outcome

Eur Spine J 2010 19 3 439–442

71.

Saxler

Krämer

Barden

Kurt

Pförtner

Bernsmann

The long-term clinical sequelae of incidental durotomy in lumbar disc surgery

Spine (Phila Pa 1976) 2005 30 20 2298–2302

72.

Rothoerl

R D

Woertgen

Brawanski

When should conservative treatment for lumbar disc herniation be ceased and surgery considered?

Neurosurg Rev 2002 25 3 162–165

73.

Moranjkic

Ercegovic

Hodzic

Brkic

Outcome prediction in lumbar disc herniation surgery

Acta Med Sal 2010 39 2 75–80

74.

den Boer

J J

Oostendorp

R AB

Beems

Munneke

Oerlemans

Evers

A W

A systematic review of bio-psychosocial risk factors for an unfavourable outcome after lumbar disc surgery

Eur Spine J 2006 15 5 527–536

75.

Olson

P R

Lurie

J D

Frymoyer

, et al.

Lumbar disc herniation in the Spine Patient Outcomes Research Trial: does educational attainment impact outcome?

Spine (Phila Pa 1976) 2011 36 26 2324–2332

76.

Edwards

R R

Klick

Buenaver

, et al.

Symptoms of distress as prospective predictors of pain-related sciatica treatment outcomes

Pain 2007 130 1–2 47–55

77.

D'Angelo

Mirijello

Ferrulli

, et al.

Role of trait anxiety in persistent radicular pain after surgery for lumbar disc herniation: a 1-year longitudinal study

Neurosurgery 2010 67 2 265–271

78.

Schade

Semmer

Main

C J

Hora

Boos

The impact of clinical, morphological, psychosocial and work-related factors on the outcome of lumbar discectomy

Pain 1999 80 1–2 239–249

79.

Trief

P M

Grant

Fredrickson

A prospective study of psychological predictors of lumbar surgery outcome

Spine (Phila Pa 1976) 2000 25 20 2616–2621

80.

Ljubicić Bistrović

Ljubicić

Ekl

Penezić

Mocenić

Stancić

M F

Influence of depression on patients satisfaction with the outcome of microsurgical “key-hole” vs classical discectomy: prospective matched-cohort study

Croat Med J 2002 43 6 702–706

81.

Arpino

Iavarone

Parlato

Moraci

Prognostic role of depression after lumbar disc surgery

Neurol Sci 2004 25 3 145–147

82.

Mannion

A F

Elfering

Predictors of surgical outcome and their assessment

Eur Spine J 2006 15 01 S93–S108

83.

Cashion

E L

Lynch

W J

Personality factors and results of lumbar disc surgery

Neurosurgery 1979 4 2 141–145

84.

Nygaard

ØP

Kloster

Solberg

Duration of leg pain as a predictor of outcome after surgery for lumbar disc herniation: a prospective cohort study with 1-year follow up

J Neurosurg 2000 92 (2, Suppl): 131–134

85.

Hurme

Alaranta

Factors predicting the result of surgery for lumbar intervertebral disc herniation

Spine (Phila Pa 1976) 1987 12 9 933–938

86.

Nygaard

O P

Romner

Trumpy

J H

Duration of symptoms as a predictor of outcome after lumbar disc surgery

Acta Neurochir (Wien) 1994 128 1–4 53–56

87.

Folman

Shabat

Catz

Gepstein

Late results of surgery for herniated lumbar disk as related to duration of preoperative symptoms and type of herniation

Surg Neurol 2008 70 4 398–401, discussion 401–402

88.

Blazhevski

Filipche

Cvetanovski

Simonovska

Predictive value of the duration of sciatica for lumbar discectomy

Prilozi 2008 29 2 325–335

89.

L C

Sell

Predictive value of the duration of sciatica for lumbar discectomy. A prospective cohort study

J Bone Joint Surg Br 2004 86 4 546–549

90.

Peul

W C

Brand

Thomeer

R TWM

Koes

B W

Influence of gender and other prognostic factors on outcome of sciatica

Pain 2008 138 1 180–191

91.

Vroomen

P C

de Krom

M C

Knottnerus

J A

Predicting the outcome of sciatica at short-term follow-up

Br J Gen Pract 2002 52 475 119–123

Lumbar Disk Herniation Surgery: Outcome and Predictors

Abstract

Study Design

Objectives

Methods

Results

Conclusion

Keywords

Introduction

Materials and Methods

Surgical Methods

Data Analysis

Results

Hospital Stay

Overall Success Rate for Surgery

Surgical Complications

Cases with Recurrence

Foot Drop Cases

Recovery of Symptoms

Residual Complaints

Results in Elderly Cases

Upper LDH Cases

Mental Health

Type of Disk Herniation

Pregnancy

Return to Job

Results of Surgical Techniques

Factors Predictive of Outcome

Discussion

Outcome

Predictors

Conclusion

Disclosures Mahsa Sedighi, none Ali Haghnegahdar, Board membership: Iranian Board of Neurosurgery; Consultant: Shiraz University of Medical Sciences

Disclosures

Footnotes

Acknowledgment

References

Disclosures

Mahsa Sedighi, none

Ali Haghnegahdar, Board membership: Iranian Board of Neurosurgery; Consultant: Shiraz University of Medical Sciences