The etiology of migrainous cerebral infarction is unknown, but may involve prothrombotic coagulation abnormalities. Therefore, we studied resistance to activated protein C and the presence of the Arg506Gln factor V Leiden mutation in 20 patients, with migrainous cerebral infarction. Only one heterozygous carrier of the mutation was found, whereas other patients did not carry the mutation. This indicates that the factor V Leiden mutation is not a major risk factor for migrainous cerebral infarction.
WelchKMALevineSR.Migraine-related stroke in the context of the International Headache Society classification of head pain.
Arch Neurol1990;
47:
458–62
2.
KalendovskyZAustinJH.“Complicated migraine”: Its association with increased platelet aggregability and abnormal plasma coagulation factors.
Headache1975;
15:
18–35
3.
LevineSRJosephRD'AndreaGWelchKMA.Migraine and the lupus anticoagulant. Case report and review of the literature.
Cephalalgia1987;
7:
93–9
4.
LevineSRWelchKMA.The spectrum of neurologic disease associated with antiphospholipid antibodies.
Arch Neurol1987;
44:
876–83
5.
SilvestriniMMatteisMTroisiECupiniLMZaccariGBernardiG.Migrainous stroke and the antiphospholipid antibodies.
Eur Neurol1994;
34:
316–9
6.
DahlbackBCarlssonMSvenssonPJ.Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.
Proc Natl Acad Sci USA1993;
90:
1004–8
7.
BertinaRMKoelemanBPCKosterTRosendaalFRDirvenRJDe RondeHMutation in blood coagulation factor associated with resistance to activated protein C.
Nature1994;
369:
64–7
8.
De StefanoVLeoneG.Resistance to activated protein C due to mutated factor V as a novel cause of inherited thrombophilia.
Haematologica1995;
80:
344–56
9.
HalbmayerWMHaushoferASchonRFischerM.The prevalence of poor anticoagulant response to activated protein C (APC resistance) among patients suffering from stroke or venous thrombosis and among healthy subjects.
Blood Coagul Fibrinolysis1994;
5:
51–7
10.
SimioniPDe RondeHPrandoniPSaladiniMBertinaRMGirolamiA.Ischemic stroke in young patients with activated protein C resistance. A report of three cases belonging to three different kindreds.
Stroke1995;
26:
885–90
11.
CushmanMBhushanFBovillETravyR.Plasma resistance to activated protein C in venous and arterial thrombosis.
Thromb Haemost1994;
72:
647
12.
RidkerPMHennekensCHLindpaintnerKStampferMJEisenbergPRMiletichJP.Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke and venous thrombosis in apparently healthy men.
New Engl J Med1995;
332:
912–7
13.
CattoACarterAIrelandHBaystonTAPhilippouHBarrettJFactor V Leiden gene mutation and thrombin generation in relation to the development of acute stroke.
Arterioscler Thromb Vasc Biol1995;
15:
783–5
14.
LalouchekWSuessEAullSSchniderPUhlFZeilerKPabinger-FaschingI.Clinical and laboratory data in heterozygous factor V Leiden mutation positive versus negative patients with TIA and minor stroke.
Stroke1995;
26:
1963–4
15.
ForsythPDDolanG.Activated protein C resistance in cases of cerebral infarction.
Lancet1995;
345:
795
16.
KontulaKYlikorkalaAMiettinenHVuorioAKauppinen-MakelinRHamalainenLArg506Gln factor V mutation (Factor V Leiden) in patients with ischemic cerebrovascular disease and survivors of myocardial infarction.
Thromb Haemost1995;
73:
558–60
17.
PressRDLiuXYBeamerNCoullBM.Ischemic stroke in the elderly.
Role of common factor V mutation causing resistance to activated protein C, Stroke1996;
27:
44–8
18.
LandiGCellaEMartinelliITagliabueLMannucciPMZerbiD.Arg506Gln factor V mutation and cerebral ischemia in young adults.
Stroke1996;
27:
1697–8
19.
Headache Classification Committee of the International Headache Society.Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain.
Cephalalgia1988;
8Suppl 7:
1–96
20.
NarboneMCLeggiadroNLa SpinaPRaoRGrugnoRMusolinoR.Migraine stroke: A possible complication of both migraine with and without aura.
Headache1996;
36:
481–3
21.
De RondeHBertinaRM.Laboratory diagnosis of APC-resistance: a critical evaluation of the test and the development of diagnostic criteria.
Thromb Haemost1994;
72:
880–6
22.
FeatherstoneHJ.Clinical features of stroke in migraine.
Headache1986;
26:
128–33
23.
BroderickJPSwansonJW.Migraine-related strokes. Clinical profile and prognosis in 20 patients.
Arch Neurol1987;
44:
868–71
SacquegnaTAndreoliABaldratiALamieriCGuttmannSde CarolisPIschemic stroke in young adults: The relevance of migrainous infarction.
Cephalalgia1989;
9:
255–8
26.
RothrockJNorthJMaddenKLydenPFleckPDittrichH.Migraine and migrainous stroke: Risk factors and prognosis.
Neurology1993;
43:
2473–6
27.
Hoekstra-van DalenRAHCillessenJPMKappelleJIvan GijnJ.Cerebral infarcts associated with migraine: Clinical features, risk factors and follow-up.
J Neurol1996;
243:
511–5
28.
CiusaniEArianoCMoschianoFGrazziLD'AmicoDNespoloABussoneG.Point mutation (Arg506-Gln) of factor V in migraine with and without aura [Abstract].
Cephalalgia1996;
16:
394