The epidemiological, clinical and basic science evidence for a role of estrogen in migraine is reviewed. The hypothesis is put forward that estrogen exerts its influence by modulating sympathetic control of the cerebral vasculature.
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References
1.
BilleB.Migraine in school children.Acta Pediatr [Suppl 136]1962;51:1–151.
2.
DuebnerDC.An epidemiologic study of migraine and headache in 10--20-year-olds. Headache1977;17:173–80.
3.
SillanpaaM.Prevalence of migraine and other headache in Finnish children starting school. Headache1976;15:288–90.
4.
SparksJP.The incidence of migraine in school children-a survey by the medical officers of school association. Practitioner1978;221(1323):407–11.
5.
BrewisMPoskanzerDCRollandCMillerH.Neurological disease in an English city.Acta Neurol Scand [Suppl 24]1966;42:1–89.
6.
Dalsgaard-NielsenTUlrichJ.Prevalence and heredity of migraine and migranoid headaches among 461 Danish doctors. Headache1972;12:168–72.
7.
EkbomJAhlborgBScheleR.Prevalence of migraine and cluster headache in Swedish men of 18. Headache1978;18:9–19.
8.
WatersWE.Epidemiology. In:PearceJ edModern topics in migraine.London:Heinemann,1975:8–21.
9.
WatersWE.Migraine, intelligence, social class and familial prevalence. Br Med J1971;ii:77–81.
10.
WatersWE.Migraine in general practitioners. Br J Prey Soc Med1975;29:48–52.
11.
WatersWEO'ConnorPJ.Epidemiology of headache and migraine in women. J Neurol Neurosurg Psychiatry1971;34:148–53.
12.
Dalsgaard-NielsenT.Some aspects of the epidemiology of migraine in Denmark. Headache1970;10:14–23.
13.
MarkushREKarpHRHeymanAO'FallonWM.Epidemiological study of migraine symptoms in young women. Neurology1975;25:430–35.
14.
Fitz-HughT.Jr.Precordial migraine; an important form of "angina innocens". New Int Clin1940;1:143–5.
15.
Ask-UpmarkE.Migraine as a deadly diseaseBr Med J1960;5202:823–5.
16.
NatteroG.Menstrual headache. Advances in Neurology1982;33:215–26.
17.
EpsteinMTHockadayJMHockadayTDR.Migraine and reproductive hormones throughout the menstrual cycle. Lancet1975;1:543–7.
18.
GreenRDaltonK.The premenstrual syndrome. Br Med J1953;1:1007–14.
19.
DonaldsonJ.Neurology of pregnancy, vol 7 in the series Major problems in neurology,WB Saunders Co,Philadelphia1978:183–8.
20.
SomervilleB.A study of migraine in pregnancy. Neurology1972;22:824.
21.
Singh et al.Progesterone in migraine.Lancet1947;1:745.
22.
SacksO.Migraine, the evolution of a common disorder.University Press,Berkeley and Los Angeles, CA1970:169–70.
23.
CallaghanN.The migraine syndrome in pregnancy. Neurology1968;18:197–201.
24.
WhittyCWMHockadayJM.Migraine: a follow-up study of 92 patients. Br Med J1968;1:735.
25.
KleeA.A clinical study of migraine with particular reference to the most severe cases.Munksgaard,Copenhagen1968.
26.
MartyMG.La place de I hysterectomie avec conservation annexielle darts le traitment des migraines cataminiales gravatives et rebelles, apres 45 ans. Bull Fed Soc Gyn Obstet1971;23:333.
27.
SoordsV.Hemiplegic migraine associated with menstruation. J Obstet and Gyn Br C'Wealth1971;78:762–3.
28.
MearsEGrantECG."Anovlar" as an oral contraceptive. Br Med J1962;5297:75.
29.
WhittyCWMHockadayJMWhittyMM.The effect of oral contraceptives on migraine. Lancet1966;1:856–9.
30.
PhillipsBM.Contraceptive drugs and migraine.Br Med J1968;299.
31.
KudrowL.The relationship of headache frequency to hormone use in migraine. Headache1975;15:37–40.
32.
NilssonAJacobsenLIngemansonCa.Side effects of an oral contraceptive with particular attention to mental symptoms and sexual adaptation. Acta Obstet Gynecol Scand1967;46:537–56.
33.
Larson-CohnVLundbergPO.Headache and treatment with oral contraceptives.1970;46:267–78.
34.
CarrollJD.Migraine and oral contraception. In:Proceedings of the International Headache Symposium,Sandoz, Basle1971;45–9.
35.
GrantECG.Relation between headaches from oral contraceptives and development of endometrial arterioles. Br Med J1968;3:402–5.
36.
HertzbertBCoppenA.Changes in psychological symptoms in women taking oral contraceptives. Br J Psychol1970;116:161–4.
37.
SomervilleBW.The role of estradiol withdrawal in the etiology of menstrual migraine. Neurology1972;22:355.
38.
SomervilleBW.Estrogen-withdrawal migraine I. Duration of exposure required and attempted prophylaxis by premenstrual estrogen administration.Neurology1975;25:239–44.
39.
SomervilleBW.Estrogen-withdrawal migraine II. Attempted prophylaxis by continuous estradiol administration.Neurology1975;25:245–50.
40.
HorthCEWainscottGNeylanCWilkinsonIP.Progesterone, estradiol and aldosterone levels in plasma during the menstrual cycle of women suffering from migraine. J Endocrinol1975;65(3):24P–25P.
41.
HockadayJMMacMillanALWhittyCWM.Vasomotor-reflex response in idiopathic and hormone dependent migraine.Lancet1967:1023.
42.
LundbergPO.Migraine prophylaxis with progestogens. Acta Endocrinol [Suppl] (Copenh)1962;68:1.
43.
GrayLA.The use of progesterone in nervous tension states. South Med J1941;34:1004.
44.
BradleyWG et al.Double blind control trial of a micronized preparation of Flumedroxone in pro-phylaxis of migraine.Br Med J1968;3:531–3.
45.
FanciullacciM.Iris adrenergic impairment in idiopathic headache. Headache1979;19:8–13.
46.
SakaiFMeyerJ.Abnormal cerebrovascular reactivity in patients with migraine and cluster headache. Headache1979;19:257.
47.
SimardDPaulsonOB.Cerebral vasomotor paralysis during migraine attack. Arch Neurol1973;29:207.
48.
OwmanCEdvinssonL.Neurogenic control of brain circulation.Oxford/Toronto:Pergamon,1977.
49.
SamarasingeDD.The innervation of the cerebral arteries in the rat: an electron microscope study. J Anat1965;99:815.
50.
SatoS.An electron microscope study on the innervation of the intracranial arteries of the rat. Am J Anat1966;118:873.
51.
ShimazuE et al.Demonstration of autonomic action potential from cerebral arteries.Acta Neurol Scand [Suppl 72]1979;60:98.
PurvesMJ.The physiology of the cerebral circulation, monographs of the physiological society. No 28,Cambridge Univ Press1972:253–81.
54.
OwmanCEdvinssonLHardeboJE.Pharmacological in vitro analysis of amine-mediated vasomotor functions in the intracranial and extracranial vascular beds. Blood Vessels1978;15:128–47.
55.
ShalitMN et al.CO2 and cerebral circulation control.Arch Neurol1967;17:337–53.
56.
McGrathJC.Evidence for more than one type of post-junctional alpha-adrenoceptor. Biochem Pharmacol1982;31(4):467–84.
57.
LangerSZSheppersonNBMassinghamR.Preferential noradrenergic innervation of alpha-adrenergic receptors in vascular smooth muscle.Hypertension [Suppl 1]1981;I:112–18.
58.
SkarbyRAndersonKEEdvinssonL.Characterization of the post-synaptic alpha-adrenoceptor in isolated feline cerebral arteries. Acta Physiol Scand1981;112:105–7.
59.
StevensMJRittinghausenREMouldsRFW.Heterogeneity of human vascular pre-and post-synaptic alpha-adrenoceptors. Clin Sci1981;61:203s–6s.
60.
BobikA.Identification of alpha-adrenoceptor sub-types in dog arteries by 3H-yohimbine and 3H-prasozin. Life Sci1982;30:219–28.
61.
KobingerWPichlerL.Alpha 1 and alpha 2--adrenoceptor subtypes: selectivity of various agonists and relative distribution of receptors as determined in rats. Eur J Pharmacol1981;73:313–21.
62.
LimYLWaitersWAW.Oestrogens and the maternal circulation. Aust NZ J Obstet Gynecol1970;10:61.
63.
NuwayidB et al.Effects of estrogens on systemic and regional circulation in normal and renal hypertensive sheep.J Obstet Gynecol1975;123:495.
64.
AlturaBMAlturaBT.Some physiological factors in vascular reactivity.V. Influences of sex hormones, oral contraceptives and pregnancy on vascular muscle and its reactivity. Reprinted from Carrier O, Shibata S eds Factors influencing vascular reactivity,Igaku-Shoin Ltd,Tokyo1977:221.
65.
AlturaBM.Sex as a factor influencing the responsiveness of arterioles to catecholamines. Eur J Pharmacol1972;20:261.
66.
AlturaBMAlturaBT.Vascular smooth muscle and neurohypophyseal hormones. Fed Proc1972;36:1853.
67.
GorskiJGannonF.Current models of steroid hormone action: a critique. In:Annual review of physiology,1976;38:425–50.
68.
BuchanPLewisAJSugrueMF.A comparison of the accumulation of noradrenalin and serotonin into arterial smooth muscle. Br J Pharmacol1974;52(1):132P–33P.
69.
HardeboJENilssonBOwmanCH.The effect of a short-lasting intracarotid injection of sympathiomimetic and serotonergic receptor stimulants upon cerebral blood flow, as measured by a venous outflow method. In:GotohFNagaiHTazakiY edsCerebral blood flow and metabolism.Acta Neurol Scand [Suppl 72]1979;60:136–7.
70.
EdvinssonLMacKenzieE.Amine mechanism in the cerebral circulation. Pharmacol Rev1977;28(4):276–323.
71.
BallP et al.Interactions between estrogens and catecholamines. III. Studies on the methylation of catechol estrogens, catecholamines and other catechols by the catechol-o-methyltransferase of human liver.J Clin Endocrinol Metab1972;34:736–46.
FishmanJ.Biological action of catechol oestrogens. J Endocrinol1981;89:59P–65P.
74.
LuineVNKhylchevskayaRIMcEwenBS.Effect of gonadal steroids on activities of monoamine oxidase and choline acetylase in rat brain. Brain Res1975;86:283–306.
75.
HolzbauerMYoudimM.The oestrus cycle and monoamine oxidase activity. Br J Pharmacol1973;48:600–8.
76.
NicolCJMRaeRM.Inhibition of accumulation of adrenalin and noradrenalin in arterial smooth muscle by steroids. Br J Pharmacol1972;44:361P.
77.
MendelowAD et al.The effect of steroid hormones on cerebral blood flow before and after intracarotid infusion of 5--hydroxytryptamine.
78.
MendelowAD et al.Cerebrovascular response to infused 5--HT in the baboon, Part 1.5--HT infusion.Stroke1977;8(3):322.
79.
MendelowAD et al.Cerebrovascular response to infused 5--HT in the baboon, Part 2.5--HT infusion in estrogen and progesterone treated animals.Stroke1977;8(3):326.
80.
EidelmanBH et al.Potentiation of the cerebrovascular response to intraarterial 5--hydroxytryptamine.Am J Physiol1978;234(3):H300.
81.
HardeboJEEdvinssonL.Reduced sensitivity to alpha- and beta-adrenergic receptor agonists of intra- and extracranial vessels during pregnancy. Relevance to migraine.Acta Neurol Scand [Suppl 56]1977;(64):204–5.
82.
RobertsJMGoldfienRDTsuchiyaAMGoldfienAInselPA.Estrogen treatment decreases alpha-adrenergic binding sites on rabbit platelets. Endo1979;104:722–8.
83.
AbramsWBSolomonHM.The human platelet as a pharmacological model for the adrenergic neuron The uptake and release of norepinephrine. Clin Pharmacol Ther1969;10:702–9.
