How do genes encode for the formation of morphological structures such as the brain? Can genetic material also encode for behavior such as cognition, language, or culture? For many years, evolutionary biologists as well as scholars who work within extrabiological fields such as psychology, linguistics, and archaeology could only answer the above two questions in a speculative manner. This is because until recently, empirical observations on how genes underlie anatomy or behavior were generally lacking. This situation has now changed. Several genes (MCPH1-MCPH6) have been implicated in the regulation of brain size and a first gene (the FOXP2 gene) has been identified that might underlie linguistic behavior. These discoveries allow us to finally test some of the long-standing theoretical assumptions on how genes do or do not determine morphology and behavior.
BishopD. V. M. (2002a). The role of genes in the aetiology of specific language impairment. Journal of Communication Disorders, 35, 311–328.
2.
BishopD. V. M. (2002b). Putting language genes in perspective. Trends in Cognitive Sciences, 18, 57–59.
3.
BishopD. V. M. (2003). A comparison of language abilities in adolescents with Down Syndrome and children with specific language impairment. Journal of Speech, Language, and Hearing Research, 46, 1324–1339.
4.
BonkowskyJ. L., & ChienC. (2005). Molecular cloning and developmental expression of foxP2 in Zebrafish. Developmental Dynamics, 234, 740–746.
5.
CallebautW. (1993). Taking the naturalistic turn or how real philosophy of science is done. Chicago: The University of Chicago Press.
6.
CarlssonP., & MahlapuuP. (2002). Forkhead transcription factors: Key players in development and metabolism. Developmental Biology, 250, 1–23.
7.
ChomskyN. (1959). A review of B. F. Skinner's verbal behaviour. Language, 35, 26–58.
8.
ChomskyN. (1965). Aspects of the theory of syntax. Cambridge, MA: The MIT Press.
9.
CurratM., (2006). Comment on ‘Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens‘ and ‘Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans. Science, 313, 172a.
10.
DawkinsR. (1983). Universal Darwinism. In HullD. & RuseM. (1998), The philosophy of biology (pp. 15–35). New York: Oxford University Press.
11.
DawkinsR. (1995). River out of Eden. San Francisco: Harper Collins.
12.
EnardW., (2002). Molecular evolution of FOXP2, a gene involved in speech and language. Nature, 418, 869–872.
13.
EvansP., (2006). Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage. Proceedings of the National Academy of Sciences, USA, 103, 18178–18183.
14.
EvansP. D., (2005). Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans. Science, 309, 1717–1720.
15.
EvansP. D., VallenderE. H., & LahnB. T. (2006). Molecular evolution of the brain size regulator genes CDK5RAP2 and. CENPJ. Gene, 375, 75–79.
16.
FerlandR. J., (2003). Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain. The Journal of Comparative Neurology, 460, 266–279.
17.
FeukL., (2006). Absence of a paternally inherited FOXP2 gene in developmental verbal dyspraxia. The American Journal of Human Genetics, 79, 965–972.
18.
FisherS. E. (2006). Tangled webs: Tracing the connections between genes and cognition. Cognition, 101, 270–297.
19.
FisherS. E., & MarcusG. F. (2006). The eloquent ape: Genes, brains, and the evolution of language. Nature Reviews, Genetics, 7, 9–20.
20.
GehringW. (1998). Master control genes in development and evolution: The homeobox story. London: Yale University Press.
21.
GilbertS. L., DobynsW. B., & LahnB. (2005). Genetic links between brain development and brain evolution. Nature reviews, genetics, 6, 581–590.
22.
GontierN. (2006a). An epistemological inquiry into the “what is language” question and the ‘what did language evolve for’ question. In CangelosiA., SmithA. D. M., & SmithK., The evolution of language: Proceedings of the 6th international conference (Evolang 6) (pp. 107–115). London: World Scientific.
23.
GontierN. (2006b). Introduction to evolutionary epistemology, language and culture. In GontierN., Van BendegemJ. P., & AertsD., Evolutionary epistemology, language and culture (pp. 1–29). Dordrecht: Springer.
24.
GontierN. (2006c). Language and pathologies: An epistemological reflection. Cognitive Systems, 7, 33–60.
25.
GontierN. (2008). The dynamics of language activity, an evolutionary reconstruction. Unpublished doctoral dissertation, Vrije Universiteit Brussels, Brussels, Belgium.
26.
GopnikM. (1990). Feature-blind grammar and dysphasia. Nature, 344, 715.
27.
HaeslerS., (2004). FoxP2 expression in Avian vocal learners and non-learners. The Journal of Neuroscience, 24, 3164–3175.
28.
HollowayR. L. (1999). Evolution of the human brain. In LockA., & PetersC., Handbook of human symbolic evolution (pp. 74–125). Oxford: Blackwell Publishers.
29.
HurstJ. A., (1990). An extended family with a dominantly inherited speech disorder. Developmental Medicine and Child Neurology, 32, 352–355.
30.
KleinR. G. (1999). The human career. Chicago: The University of Chicago Press.
31.
KrauseJ., Lalueza-FoxC., OrlandoL., EnardW., GreenR. E., BurbanoH. A., (2007). The derived FOXP2 variant of modern humans was shared with Neanderthals. Current Biology, 17, 1908–1912.
32.
LaiC. S., (2000). The SPCH1 region on Human 7q31: Genomic characterization of the critical interval and localization of translocations associated with speech and language disorder. American Journal of Human Genetics, 67, 357–368.
33.
LaiC. S., (2001). A Forkhead-domain gene is mutated in a severe speech and language disorder. Nature, 413, 519–523.
34.
LaiC. S., (2003). FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder. Brain, 126, 2455–2462.
35.
LiégeoisF., (2003). Language fMRI abnormalities associated with FOXP2 gene mutation. Nature Neuroscience, 6, 1230–1237.
36.
MacDermotK. D., (2005). Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits. American Journal of Human Genetics, 76, 1074–1080.
37.
MarcusG., & FisherE. (2003). FOXP2 in focus: What can genes tell us about speech and language?Trends in Cognitive Sciences, 7, 257–262.
38.
MayrE. (1961). Cause and effect in biology. In MayrE., 1997, Evolution and the diversity of life: Selected essays (pp. 359–382). Cambridge, MA: Harvard University Press.
39.
McBreatyS., & BrooksA. (2000). The revolution that wasn't: A new interpretation of the origin of modern human behaviour. Journal of Human Evolution, 39, 453–563.
40.
Mekel-BobrovN., (2005). Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens. Science, 309, 1720–1722.
41.
MellarsP. A., & StringerC. (1989). Introduction: The origins and dispersal of modern humans. In MellarP. A. & StringerC., The human revolution: Behavioural and biological perspectives on the origins of modern humans (pp. 1–14). Princeton: Princeton University Press.
42.
PinkerS. (2001). Talk of genetics and vice versa. Nature, 413, 465–466.
43.
PinkerS., & BloomP. (1990). Natural language and natural selection. Behavioural and Bran Sciences, 13, 707–784.
44.
SchrödingerE. (2000/1944). What is life?Cambridge, MA: Cambridge University Press: Canto.
45.
SchwartzJ. H. (1999). Sudden origins: Fossils, genes, and the emergence of species. New York: Wiley.
46.
ShahR., (2006). Expression of FoxP2 during zebrafish development and in the adult brain. International Journal of Developmental Biology, 50, 435–438.
47.
ShankerS., & KingB. (2002). The emergence of a new paradigm in ape language research. Behavioral and Brain Sciences, 25, 605–656.
48.
ShuW., (2005). Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene. Proceedings of the National Academy of Sciences, USA, 102, 9643–9648.
49.
TakhahashiK., (2003). Expression of Foxp2, a gene involved in speech and language in the developing and adult stratum. Journal of Neuroscience Research, 73, 61–72.
50.
TamuraS., (2003). Expression pattern of the winged-helix/forkhead transcription factor FoxP1 in the developing central nervous system. Gene Expression Patterns, 3, 193–197.
51.
TeramitsuI., (2004). Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. The Journal of Neuroscience, 24, 3152–3163.
52.
TomaselloM. (2004). The human adaptation for culture. In WuketitsF. & AntweilerC., Handbook of human evolution (Vol. 1, pp. 1–23). Weinheim: Wiley-VCH Verlag GmbH & Co.
53.
Vargha-KhademF., (1995). Praxis and nonverbal cognitive deficits in a large family with a genetically transmitted speech and language disorder. Proceedings of the National Academy of Science, USA, 92, 930–933.
54.
Vargha-KhademF., (1998). Neural basis of an inherited speech and language disorder. Proceedings of the National Academy of Science, USA, 95, 12695–12700.
55.
Vargha-KhademF., (2005). FOXP2 and the neuroanatomy of speech and language. Nature Reviews, Neuroscience, 6, 131–138.
56.
WhiteS. A., (2006). Singing mice, songbirds, and more: Models for FOXP2 function and dysfunction in human speech and language. The Journal of Neuroscience, 26, 10376–10379.
57.
WilliamsG. C. (1966). Adaptation and natural selection. Princeton: Princeton University Press.
58.
WoodsR. P., (2006). Normal variants of Microcephalin and ASPM do not account for brain size variability. Human Molecular Genetics, 15, 2025–2029.
59.
ZeesmanS. (2006). Speech and language impairment and oromotor dyspraxia due to deletion of 7q31 that involves FOXP2. American Journal of Medical Genetics, 140A, 509–514.
60.
ZhangJ., WebbD. M., & PodlahaO. (2002). Accelerated protein evolution and origins of human-specific features: FOXP2 as an example. Genetics, 162, 1825–1835.
