Sage Journals: Discover world-class research

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Research article

First published 2025-11

RNAS-sgRNA: Recurrent Neural Architecture Search for Detection of On-Target Effects in Single Guide RNA

Shehla Rafiq, Assif Assad

Journal of Computational Biology

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Research article

First published 2026

Computational Optimization of CRISPR-Cas13a sgRNAs Targeting the SARS-CoV-2 Spike Gene for SHERLOCK-Based Diagnostics

Maryam Ahmadzadeh, Fatemeh Akbarian, Mohammad Hossein Sanati [...]

Evolutionary Bioinformatics

Open access

Review article

First published 2022-10

RNA-Responsive gRNAs for Controlling CRISPR Activity: Current Advances,Future Directions,and Potential Applications

Oana Pelea, Tudor A. Fulga, Tatjana Sauka-Spengler

The CRISPR Journal

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Research article

First published 2022-12

Natural Nucleoside Modifications in Guide RNAs Can Modulate the Activity of the CRISPR-Cas9 System In Vitro

Daria V. Prokhorova, Ivan P. Vokhtantsev, Polina O. Tolstova [...]

The CRISPR Journal

Open access

Research article

First published 2024-12

Mass Spectrometry as a Quantitative Tool for SpCas9 sgRNA Quality Control

Juan Daniel Avila, Puzhou Wang

Nucleic Acid Therapeutics

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Research article

First published 2017-08

CRISPR Guide RNA Validation In Vitro

Stephanie Grainger, Brianna Lonquich, Chet Huan Oon [...]

Zebrafish

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Research article

First published 2022-12

Bio-Orthogonal Chemistry Conjugation Strategy Facilitates Investigation of N-methyladenosine and Thiouridine Guide RNA Modifications on CRISPR Activity

Alyssa Hoy, Ya Ying Zheng, Jia Sheng [...]

The CRISPR Journal

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Research article

First published 2024-08

Genome Editing of Mammalian Cells Through RNA Transcript-Mediated Homologous Recombination Repair

Yangmin Wang, Meilin Liu, Xinjian Lin [...]

Human Gene Therapy

Free access

Research article

First published 2021-2

Core Hairpin Structure of SpCas9 sgRNA Functions in a Sequence- and Spatial Conformation–Dependent Manner

Mingjun Jiang, Yanzhen Ye, Juan Li

Journal of Laboratory Automation

Retricted access

Research article

First published 2021-12

Expanding the Toolkit for Genome Editing in a Disease Vector,Aedes aegypti: Transgenic Lines Expressing Cas9 and Single Guide RNA Induce Efficient Mutagenesis

Guan-Heng Zhu, Najla M. Albishi, Xien Chen [...]

The CRISPR Journal

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