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Retricted access

Review article

First published 2017-08

Recommendations of the Oligonucleotide Safety Working Group's Formulated Oligonucleotide Subcommittee for the Safety Assessment of Formulated Oligonucleotide-Based Therapeutics

Jennifer L. Marlowe, Violetta Akopian, Priya Karmali [...]

Nucleic Acid Therapeutics

Free access

Review article

First published 2006-4

Oligonucleotide-Based Therapeutic Options against Hepatitis C Virus Infection

Janie B Trepanier, Jerome E Tanner, Caroline Alfieri

Antiviral Therapy

Retricted access

Review article

First published 2014-10

Considerations for Assessment of Reproductive and Developmental Toxicity of Oligonucleotide-Based Therapeutics

Joy Cavagnaro, Cindy Berman, Doug Kornbrust [...]

Nucleic Acid Therapeutics

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Research article

First published 2016-04

OSWG Recommendations for Genotoxicity Testing of Novel Oligonucleotide-Based Therapeutics

Cindy L. Berman, Scott A. Barros, Sheila M. Galloway [...]

Nucleic Acid Therapeutics

Retricted access

Research article

First published 2026-4

An Industry Perspective on Key Considerations for the ICH S13 Guidance: Nonclinical Safety Evaluations of Oligonucleotide-Based Therapeutics

Jennifer D Sisler, Patrik Andersson, Alan Brown [...]

International Journal of Toxicology

Retricted access

Research article

First published 2017-12

Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay

Bruno M.D.C. Godinho, James W. Gilbert, Reka A. Haraszti [...]

Nucleic Acid Therapeutics

Retricted access

Review article

First published 2014-08

Recommendations for Safety Pharmacology Evaluations of Oligonucleotide-Based Therapeutics

Cindy L. Berman, Keri Cannon, Yi Cui [...]

Nucleic Acid Therapeutics

Retricted access

Research article

First published 2016-08

Considerations for the Characterization and Interpretation of Results Related to Alternative Complement Activation in Monkeys Associated with Oligonucleotide-Based Therapeutics

Scott P. Henry, Rosanne Seguin, Joy Cavagnaro [...]

Nucleic Acid Therapeutics

Open access

Research article

First published 2025-02

Bioanalytical Assays for Oligonucleotide Therapeutics: Adding Antibody-Based Immunoassays to the Toolbox as an Orthogonal Approach to LC-MS/MS and Ligand Binding Assays

David P. Chimento, Amy L. Anderson, Inês Fial [...]

Nucleic Acid Therapeutics

Open access

Research article

First published 2025-12

Use of a Transgenic Human PNPLA3 I148M Knock-in Mouse for Translational Safety Evaluations of siRNA Therapeutics

Ben Brooks, Artem Shkumatov, Jackson Kalanzi [...]

Nucleic Acid Therapeutics

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