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Retricted access

Research article

First published 2019-1

Mouse,rat,and dog bioavailability and mouse oral antidepressant efficacy of ( 2R,6R )-hydroxynorketamine

Jaclyn N Highland, Patrick J Morris, Panos Zanos [...]

Journal of Psychopharmacology

Open access

Review article

First published 2017

Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine’s Antidepressant Action

Lily R. Aleksandrova, Yu Tian Wang, Anthony G. Phillips

Chronic Stress

Open access

Research article

First published 2020

(2 S,6 S )- and (2 R,6 R )-hydroxynorketamine inhibit the induction of NMDA receptor-dependent LTP at hippocampal CA1 synapses in mice

Heather Kang, Pojeong Park, Muchun Han [...]

Brain and Neuroscience Advances

Retricted access

Research article

First published 2022-2

Sex-dependent metabolism of ketamine and ( 2R,6R )-hydroxynorketamine in mice and humans

Jaclyn N Highland, Cristan A Farmer, Panos Zanos [...]

Journal of Psychopharmacology

Open access

Article commentary

First published 2018

Is the History Repeated? Can (2 R,6 R )-Hydroxynorketamine be Another Antidepressant?

Shigeyuki Chaki, Jun-ichi Yamaguchi

Neuroscience Insights

Open access

Research article

First published 2023-03

(2R,6R)-Hydroxynorketamine Treatment of Rats Exposed to Repetitive Low-Level Blast Injury

Georgina Perez Garcia, Gissel M. Perez, Rita De Gasperi [...]

Neurotrauma Reports

Open access

Article commentary

First published 2019

Structural Plasticity Induced by Ketamine in Human Dopaminergic Neurons as Mechanism Relevant for Treatment-Resistant Depression

Ginetta Collo, Laura Cavalleri, Emilio Merlo Pich

Chronic Stress

Open access

Research article

First published 2025-6

A randomized,double-blind,placebo-controlled,Phase 1 study to investigate the safety,tolerability,pharmacokinetics and pharmacodynamics of an immediate-release oral ketamine capsule in healthy volunteers

Mutahira Qureshi, Daniel Silman, Romayne Gadelrab [...]

Journal of Psychopharmacology

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