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Retricted access

Research article

First published 2007-9

Sex Differences in QT Interval Variability and Implication on Sample Size of Thorough QT Study

Lu Zhang, Brian P. Smith

Therapeutic Innovation & Regulatory Science

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Other

First published 2005-10

A Simulation Study of Power in Thorough QT/QTc Studies and a Normal Approximation for Planning Purposes

Balakrishna Hosmane, Charles Locke

Therapeutic Innovation & Regulatory Science

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Other

First published 2011-5

Assessing a Drug's Proarrhythmic Liability: An Overview of Computer Simulation Modeling,Nonclinical Assays,and the Thorough QT/QTc Study

Lawrence Z. Satin, Todd A. Durham, J. Rick Turner

Therapeutic Innovation & Regulatory Science

Retricted access

Research article

First published 2015-5

Lessons Learned From Hundreds of Thorough QT Studies

Joanne Zhang, Huifang Chen, Yi Tsong [...]

Therapeutic Innovation & Regulatory Science

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Research article

First published 2014-3

Circadian Variation and Baseline Definition in Parallel-Group Thorough QT Studies

David Hoffman

Therapeutic Innovation & Regulatory Science

Free access

Research article

First published 2014-5

Evacetrapib at a Supratherapeutic Steady State Concentration Does Not Prolong QT in a Thorough QT/QTc Study in Healthy Participants

Jeffrey G. Suico, Stuart Friedrich, Kathryn A. Krueger [...]

Journal of Cardiovascular Pharmacology and Therapeutics

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Other

First published 2005-10

ICH E14: A New Regulatory Guidance on the Clinical Evaluation of QT/QTc Internal Prolongation and Proarrhythmic Potential for Non-antiarrhythmic Drugs *

Philip T. Sager, Thierry Nebout, Borje Darpo

Therapeutic Innovation & Regulatory Science

Free access

Review article

First published 2011-12

Towards a better understanding of QT interval variability

Larisa G. Tereshchenko, Ronald D. Berger

Therapeutic Advances in Drug Safety

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Other

First published 2006-7

A Confidence Interval for the Maximal Mean QT Interval Change Caused by Drug Effect

Morris L. Eaton, Robb J. Muirhead, Jessica Y. Mancuso [...]

Therapeutic Innovation & Regulatory Science

Open access

Research article

First published 2018-7

Strategic and Statistical Considerations on the QT Assessment of Volasertib

Gudrun Wallenstein, Beate Walter, Holger Fritsch [...]

Therapeutic Innovation & Regulatory Science

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