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Retricted access

Research article

First published 2020-5

Adding dose modifications into Phase II and Phase II/III seamless trials

John Spivack, Bin Cheng, Bruce Levin

Statistical Methods in Medical Research

Open access

Research article

First published 2023-5

Using dichotomized survival data to construct a prior distribution for a Bayesian seamless Phase II/III clinical trial

Benjamin Duputel, Nigel Stallard, François Montestruc [...]

Statistical Methods in Medical Research

Open access

Research article

First published 2011-8

Statistical aspects of the TNK-S2B trial of tenecteplase versus alteplase in acute ischemic stroke: an efficient,dose-adaptive,seamless phase II/III design

Bruce Levin, John LP Thompson, Bibhas Chakraborty [...]

Clinical Trials

Open access

Research article

First published 2021-12

Adaptive group sequential survival comparisons based on log-rank and pointwise test statistics

Jannik Feld, Andreas Faldum, Rene Schmidt

Statistical Methods in Medical Research

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Other

First published 2008-1

International Symposium on Adaptive Clinical Trial Designs

Christian Gluud, Anders Dejgaard, Michael Krams [...]

Therapeutic Innovation & Regulatory Science

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Research article

First published 2011-12

Seamless phase II/III designs

Nigel Stallard, Susan Todd

Statistical Methods in Medical Research

Retricted access

Research article

First published 2017-1

Addressing Challenges and Opportunities of “Less Well-Understood” Adaptive Designs

Weili He, Paul Gallo, Eva Miller [...]

Therapeutic Innovation & Regulatory Science

Open access

Research article

First published 2024-3

A diagnostic phase III/IV seamless design to investigate the diagnostic accuracy and clinical effectiveness using the example of HEDOS and HEDOS II

Amra Pepić, Maria Stark, Tim Friede [...]

Statistical Methods in Medical Research

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Research article

First published 2014-1

Adaptive Clinical Trials

Jeff Maca, Vladimir Dragalin, Paul Gallo

Therapeutic Innovation & Regulatory Science

Retricted access

Review article

First published 2019

Adaptive Design: A Review of the Technical,Statistical,and Regulatory Aspects of Implementation in a Clinical Trial

Franck Pires Cerqueira, Angelo Miguel Cardoso Jesus, Maria Dulce Cotrim

Therapeutic Innovation & Regulatory Science

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