Search results: Sage Journals

Open accessResearch articleFirst published July, 2026

An evaluation of designs for Phase I/IIa dose-finding studies in Tuberculosis

Alessandra Serra, Pavel Mozgunov, Patrick PJ Phillips [...]

Statistical Methods in Medical Research

Restricted accessResearch articleFirst published March, 2014

A Continual Reassessment Method With Cohort Size Adaptation Based on Bayesian Posterior Probabilities in Phase I Dose-Finding Studies

Tomoyuki Kakizume, Satoshi Morita

Therapeutic Innovation & Regulatory Science

Restricted accessResearch articleFirst published January, 2015

Incorporating Historical Data in Bayesian Phase I Trial Design

Kentaro Takeda, Satoshi Morita

Therapeutic Innovation & Regulatory Science

Open accessResearch articleFirst published 2025

Phase I Randomized,Placebo-Controlled,Cross-Over Dose-Finding Study of Coenzyme Q10 on Doxorubicin Pharmacokinetics during Breast Cancer Treatment

Heather Greenlee, Katherine D. Crew, Matthew Maurer [...]

Integrative Cancer Therapies

Restricted accessResearch articleFirst published March 4, 2007

Optimizing the Dose of Glutamine Dipeptides and Antioxidants in Critically Ill Patients: A Phase I Dose-Finding Study

Daren K. Heyland, Rupinder Dhaliwalm, Andrew Day [...]

Journal of Parenteral and Enteral Nutrition

Open accessResearch articleFirst published April, 2020

Designing and evaluating dose-escalation studies made easy: The MoDEsT web app

Philip Pallmann, Fang Wan, Adrian P Mander [...]

Clinical Trials

Open accessResearch articleFirst published January, 2026

Joint time-to-event partial order continual reassessment method and Joint time-to-event Bayesian logistic regression model: Statistical designs for dual agent phase I/II dose finding studies with late-onset toxicity and activity outcomes

Helen Barnett, Oliver Boix, Dimitris Kontos [...]

Statistical Methods in Medical Research

Free accessResearch articleFirst published January, 2014

A Phase I Dose-Finding Study of Silybin Phosphatidylcholine (Milk Thistle) in Patients With Advanced Hepatocellular Carcinoma

Abby B. Siegel, Rupa Narayan, Rosa Rodriguez [...]

Integrative Cancer Therapies

Restricted accessOtherFirst published October, 2008

A comprehensive comparison of the continual reassessment method to the standard 3 + 3 dose escalation scheme in Phase I dose-finding studies

Alexia Iasonos, Andrew S Wilton, Elyn R Riedel [...]

Clinical Trials

Open accessResearch articleFirst published August, 2020

An adaptive power prior for sequential clinical trials – Application to bridging studies

Adrien Ollier, Satoshi Morita, Moreno Ursino [...]

Statistical Methods in Medical Research

Open accessResearch articleFirst published July, 2026

An evaluation of designs for Phase I/IIa dose-finding studies in Tuberculosis

Alessandra Serra, Pavel Mozgunov, Patrick PJ Phillips [...]

Statistical Methods in Medical Research

Restricted accessResearch articleFirst published March, 2014

A Continual Reassessment Method With Cohort Size Adaptation Based on Bayesian Posterior Probabilities in Phase I Dose-Finding Studies

Tomoyuki Kakizume, Satoshi Morita

Therapeutic Innovation & Regulatory Science

Restricted accessResearch articleFirst published January, 2015

Incorporating Historical Data in Bayesian Phase I Trial Design

Kentaro Takeda, Satoshi Morita

Therapeutic Innovation & Regulatory Science

Open accessResearch articleFirst published 2025

Phase I Randomized,Placebo-Controlled,Cross-Over Dose-Finding Study of Coenzyme Q10 on Doxorubicin Pharmacokinetics during Breast Cancer Treatment

Heather Greenlee, Katherine D. Crew, Matthew Maurer [...]

Integrative Cancer Therapies

Restricted accessResearch articleFirst published March 4, 2007

Optimizing the Dose of Glutamine Dipeptides and Antioxidants in Critically Ill Patients: A Phase I Dose-Finding Study

Daren K. Heyland, Rupinder Dhaliwalm, Andrew Day [...]

Journal of Parenteral and Enteral Nutrition

Open accessResearch articleFirst published April, 2020

Designing and evaluating dose-escalation studies made easy: The MoDEsT web app

Philip Pallmann, Fang Wan, Adrian P Mander [...]

Clinical Trials

Open accessResearch articleFirst published January, 2026

Joint time-to-event partial order continual reassessment method and Joint time-to-event Bayesian logistic regression model: Statistical designs for dual agent phase I/II dose finding studies with late-onset toxicity and activity outcomes

Helen Barnett, Oliver Boix, Dimitris Kontos [...]

Statistical Methods in Medical Research

Free accessResearch articleFirst published January, 2014

A Phase I Dose-Finding Study of Silybin Phosphatidylcholine (Milk Thistle) in Patients With Advanced Hepatocellular Carcinoma

Abby B. Siegel, Rupa Narayan, Rosa Rodriguez [...]

Integrative Cancer Therapies

Restricted accessOtherFirst published October, 2008

A comprehensive comparison of the continual reassessment method to the standard 3 + 3 dose escalation scheme in Phase I dose-finding studies

Alexia Iasonos, Andrew S Wilton, Elyn R Riedel [...]

Clinical Trials

Open accessResearch articleFirst published August, 2020

An adaptive power prior for sequential clinical trials – Application to bridging studies

Adrien Ollier, Satoshi Morita, Moreno Ursino [...]

Statistical Methods in Medical Research