Sage Journals: Discover world-class research

Retricted access

Research article

First published 2014-3

A Continual Reassessment Method With Cohort Size Adaptation Based on Bayesian Posterior Probabilities in Phase I Dose-Finding Studies

Tomoyuki Kakizume, Satoshi Morita

Therapeutic Innovation & Regulatory Science

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Research article

First published 2015-1

Incorporating Historical Data in Bayesian Phase I Trial Design

Kentaro Takeda, Satoshi Morita

Therapeutic Innovation & Regulatory Science

Open access

Research article

First published 2025

Phase I Randomized,Placebo-Controlled,Cross-Over Dose-Finding Study of Coenzyme Q10 on Doxorubicin Pharmacokinetics during Breast Cancer Treatment

Heather Greenlee, Katherine D. Crew, Matthew Maurer [...]

Integrative Cancer Therapies

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Research article

First published 2007-03-04

Optimizing the Dose of Glutamine Dipeptides and Antioxidants in Critically Ill Patients: A Phase I Dose-Finding Study

Daren K. Heyland, Rupinder Dhaliwalm, Andrew Day [...]

Journal of Parenteral and Enteral Nutrition

Open access

Research article

First published 2020-4

Designing and evaluating dose-escalation studies made easy: The MoDEsT web app

Philip Pallmann, Fang Wan, Adrian P Mander [...]

Clinical Trials

Open access

Research article

First published 2026-1

Joint time-to-event partial order continual reassessment method and Joint time-to-event Bayesian logistic regression model: Statistical designs for dual agent phase I/II dose finding studies with late-onset toxicity and activity outcomes

Helen Barnett, Oliver Boix, Dimitris Kontos [...]

Statistical Methods in Medical Research

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Other

First published 2008-10

A comprehensive comparison of the continual reassessment method to the standard 3 + 3 dose escalation scheme in Phase I dose-finding studies

Alexia Iasonos, Andrew S Wilton, Elyn R Riedel [...]

Clinical Trials

Free access

Research article

First published 2014-1

A Phase I Dose-Finding Study of Silybin Phosphatidylcholine (Milk Thistle) in Patients With Advanced Hepatocellular Carcinoma

Abby B. Siegel, Rupa Narayan, Rosa Rodriguez [...]

Integrative Cancer Therapies

Open access

Research article

First published 2020-8

An adaptive power prior for sequential clinical trials – Application to bridging studies

Adrien Ollier, Satoshi Morita, Moreno Ursino [...]

Statistical Methods in Medical Research

Open access

Research article

First published 2024

Human Umbilical Cord–Derived Mesenchymal Stem Cells in the Treatment of Multiple Sclerosis Patients: Phase I/II Dose-Finding Clinical Study

Fatima Jamali, Mayis Aldughmi, Serin Atiani [...]

Cell Transplantation

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