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Research article

First published 2001-11

Kinetic Analysis of [ 11 C]MP4A Using a High-Radioactivity Brain Region That Represents an Integrated Input Function for Measurement of Cerebral Acetylcholinesterase Activity without Arterial Blood Sampling

Shin-Ichiro Nagatsuka, Kiyoshi Fukushi, Hitoshi Shinotoh [...]

Journal of Cerebral Blood Flow & Metabolism

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Research article

First published 2022-03-08

Age and Anterior Basal Forebrain Volume Predict the Cholinergic Deficit in Patients with Mild Cognitive Impairment due to Alzheimer’s Disease

Nils Richter, Lara-Sophia David, Michel J. Grothe [...]

Journal of Alzheimer’s Disease

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Research article

First published 2012-7-31

[ 11 C]-MP4A PET Cholinergic Measurements in Amnestic Mild Cognitive Impairment,Probable Alzheimer's Disease,and Dementia with Lewy Bodies: A Bayesian Method and Voxel-Based Analysis

Alessandra Marcone, Valentina Garibotto, Rosa Maria Moresco [...]

Journal of Alzheimer’s Disease

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Research article

First published 2005-8

Validation of [ 11 C]MP4A and [ 11 C]MP4P as tracers for quantifying brain ache activity with PET based on in vivo and in vitro human studies

Noriko Tanaka, Hajime Matsuura, Hitoshi Shinotoh [...]

Journal of Cerebral Blood Flow & Metabolism

Open access

Research article

First published 2025-4

Alzheimer-typical temporo-parietal atrophy and hypoperfusion are associated with a more significant cholinergic impairment in amnestic neurodegenerative syndromes

Nils Richter, Laura Breidenbach, Maximilian HT Schmieschek [...]

Journal of Alzheimer’s Disease

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Research article

First published 2001-3

Positron Emission Tomographic Measurement of Brain Acetylcholinesterase Activity Using N -[ 11 C]methylpiperidin-4-yl Acetate Without Arterial Blood Sampling: Methodology of Shape Analysis and its Diagnostic Power for Alzheimer's Disease

Noriko Tanaka, Kiyoshi Fukushi, Hitoshi Shinotoh [...]

Journal of Cerebral Blood Flow & Metabolism

Free access

Research article

First published 2005-8

Monte Carlo simulation for reference tissue-based linear analysis of [ 11 C]MP4A AND [ 11 C]MP4P: Assessment of optimal regions and optimization for precise measurement of brain AChE activity

Koichi Sato, Kiyoshi Fukushi, Hitoshi Shinotoh [...]

Journal of Cerebral Blood Flow & Metabolism

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Research article

First published 2018-3-27

Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer’s Disease

Shigeki Hirano, Hitoshi Shinotoh, Hitoshi Shimada [...]

Journal of Alzheimer’s Disease

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Research article

First published 2011-8

Cerebral acetylcholinesterase activity is not decreased in MS patients with cognitive impairment

Jere R Virta, Sari Laatu, Riitta Parkkola [...]

Multiple Sclerosis Journal

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