This article briefly summarises data published over the last decade which have investigated the concept that intravesical instillation of glycosaminoglycans (GAGs) hyaluronic acid and chondroitin sulfate is able to restore the GAG layer and provide a beneficial effect in protecting the bladder. In the second half of this article, pre-clinical studies which assess the effectiveness of intravesical instillation of Ialuril® after chemical or electromechanical damage to the rat bladder wall are described.
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GugliottaGCalagnaGAdileG. Is intravesical instillation of hyaluronic acid and chondroitin sulfate useful in preventing recurrent bacterial cystitis? A multicenter case control analysis. Taiwan J Obstet Gynecol2015;54 (5) 537–540
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CicioneACantielloFUccieroG. Intravesical treatment with highly-concentrated hyaluronic acid and chondroitin sulphate in patients with recurrent urinary tract infections: Results from a multicentre survey. Can Urol Assoc J2014;89-10E721–727
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GacciMSalehOGiannessiC. Bladder Instillation Therapy With Hyaluronic Acid and Chondroitin Sulfate Improves Symptoms of Postradiation Cystitis: Prospective Pilot Study. Clin Genitourin Cancer2016: In press.
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SommarivaMLLazzeriMAbrateAGuazzoniGSandriSMontorsiFIntravesical hyaluronic acid and chondroitin sulphate improve symptoms and quality of life in patients with late radiation tissue cystitis: An investigative pilot study. Eur J of Inflammation2014;12 (1): 177–185
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GibertiCGalloFCortesePSchenoneMCombined intravesical sodium hyaluronate/chondroitin sulfate therapy for interstitial cystitis/bladder pain syndrome: a prospective study. Ther Adv Urol2013;5 (4): 175–179
