The role of glycosaminoglycans (GAGs) as key components of the protective bladder barrier is well accepted. Replenishment of the GAG layer could restore the normal protective barrier function of the damaged bladder urothelium and re-establish normal permeability. A number of bladder diseases, including interstitial cystitis/ bladder pain syndrome, recurrent urinary tract infections, radiation cystitis, and other forms of cystitis may ben-efit from GAG therapy.
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