Bronchiolitis obliterans organizing pneumonia (BOOP), also known as cryptogenic organizing pneumonia, has mainly been described in patients with breast cancer who received radiotherapy after breast-conserving surgery. In this rare case, a 70-year-old man with left apical squamous lung cancer developed BOOP after radiotherapy and only one cycle of concomitant chemotherapy.
This case report draws attention to the development of this syndrome in the unusual setting of lung cancer, advising prompt steroid treatment when diagnostic images reveal the characteristic signs of the disease.
TakigawaN.SegawaY.SaekiT.Bronchiolitis obliterans organizing pneumonia syndrome in breast-conserving therapy for early breast cancer: radiation-induced lung toxicity. Int J Radiat Oncol Biol Phys.2000; 48(3): 751–755.
2.
KatayamaN.SatoS.KatsuiK.Analysis of factors associated with radiation-induced bronchiolitis obliterans organizing pneumonia syndrome after breast-conserving therapy. IntJ Radiat Oncol Biol Phys.2009; 73(4): 1049–1054.
3.
CrestaniB.KambouchnerM.SolerP.Migratory bronchiolitis obliterans organizing pneumonia after unilateral radiation therapy for breast carcinoma. Eur Respir J.1995; 8(2): 318–321.
EplerG.R.ColbyT.V.McLoudT.C.CarringtonC.B.GaenslerE.A.Bronchiolitis obliterans organizing pneumonia. N Engl J Med.1985; 312(3): 152–158.
6.
CrestaniB.ValeyreD.RodenS.WallaertB.DalphinJ.C.CordierJ.F.Bronchiolitis obliterans organizing pneumonia syndrome primed by radiation therapy to the breast. The Groupe d'Etudes et de Recherche sur les Maladies Orphelines Pulmonaires (GERM“O”P). AmJ Respir Crit Care Med.1998; 158(6): 1929–1935.
7.
MuraiT.ShibamotoY.NishiyamaT.Organizing pneumonia after stereotactic ablative radiotherapy of the lung. Radiat Oncol.2012; 7(1): 123.
GorterR.R.VosC.G.HalmansJ.HarteminkK.J.PaulM.A.OosterhuisJ.W.Evaluation of arm function and quality of life after trimodality treatment for superior sulcus tumours. Interact Cardiovasc Thorac Surg.2013; 16(1): 44–48.
11.
TsujinoK.HashimotoT.ShimadaT.Combined analysis of V20, VS5, pulmonary fibrosis score on baseline computed tomography, and patient age improves prediction of severe radiation pneumonitis after concurrent chemoradiotherapy for locally advanced non-small-cell lung cancer. J Thorac Oncol.2014; 9(7): 983–990.
12.
MiwasMoritaS.SudaT.The incidence and clinical characteristics of bronchiolitis obliterans organizing pneumonia syndrome after radiation therapy for breast cancer. Sarcoidosis Vase Diffuse Lung Dis.2004; 21: 212–218.
13.
BalduinR.GiacomettiC.SaccarolaL.Acute fibrinous and organizing pneumonia in a patient with collagen vascular disease “stigma”. Sarcoidosis Vase Diffuse Lung Dis.2007; 24(1): 78–80. Letter.
14.
AndoM.OkamotoI.YamamotoN.Predictive factors for interstitial lung disease, antitumor response, and survival in non-small-cell lung cancer patients treated with gefitinib. J Clin Oncol.2006; 24(16): 2549–2556.
15.
ShogbonA.O.HapJ.DretlerR.DalviA.G.Cryptogenic organizing pneumonia during adjuvant chemotherapy with oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX) for colon cancer. J Pharm Pract.2013; 26(1): 62–66.
16.
FekrazadM.H.EberhardtS.JonesD.V.LeeF.C.Development of bronchiolitis obliterans organizing pneumonia with platinum-based chemotherapy for metastatic rectal cancer. Clin Colorectal Cancer.2010; 9(3): 177–178.
17.
DahlqvistC.FremaultA.CarrascoJ.ColinetB.[Obliterative bronchiolitis with organising pneumonia following FOLFOX 4 chemotherapy]Rev Mai Respir.2010; 27(1): 84–87.
18.
HaroonA.HigaF.HibiyaK.Organizing pneumonia pattern in the follow-up CT of Legionella-infected patients. J Infect Chemother.2011; 17(4): 493–498.
19.
CunhaB.A.SyedU.MickailN.Renal transplant with bronchiolitis obliterans organizing pneumonia (BOOP) attributable to tacrolimus and herpes simplex virus (HSV) pneumonia. Heart Lung.2012; 41(3): 310–315.
20.
ChengT.H.KoF.C.ChangJ.L.WuK.A.Bronchiolitis obliterans organizing pneumonia due to titanium nanoparticles in paint. Ann Thorac Surg.2012; 93(2): 666–669.
21.
CottinV.FrognierR.MonnotH.LevyA.DeVuystP.CordierJ.F.; Groupe d'Etudes et de Recherche sur les Maladies “Orphelines” Pulmonaires. Chronic eosinophilic pneumonia after radiation therapy for breast cancer. Eur Respir J.2004; 23(1): 9–13.
22.
PrakashU.B.S.Radiation-induced injury in the “nonirradiated” lung. Eur Respir J.1999; 13(4): 715–717.
