Pheochromocytoma (PHEO), a rare catecholamine-producing tumor, is a disease entity with variable clinical manifestations. The classic triad of symptoms are palpitations, headaches, and diaphoresis, but the signs and symptoms are wide ranging and mainly reflect the hemodynamic and metabolic actions of the catecholamines produced and secreted by the tumor. We describe the rare case of a patient affected by nonfunctioning and asymptomatic PHEO associated with the incidental discovery of renal oncocytoma, and review the literature.
PlouinPFGimenez-RoqueploAPPheochromocytomas and secreting paragangliomas. Orphanet J Rare Dis20061149
2.
SundahlNVan SlyckeSBrusselaersNA rare case of clinically and biochemically silent giant right pheochromocytoma: case report and review of literature. Acta Chir Belg20161164239–242
3.
CotestaDPetramalaLSerraV. Clinical experience with pheochromocytoma in a single centre over 16 years. High Blood Press Cardiovasc Prev2009164183–193
4.
LendersJWDuhQYEisenhoferGet al;Endocrine Society. Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab20149961915–1942
5.
MochHCubillaALHumphreyPAReuterVEUlbrightTMThe 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. Eur Urol201670193–105
6.
DaskalopoulosGDelakasDCharoulakisNGourtsoyiannisNCranidisACoexisting nonfunctioning pheochromocytoma and renal oncocytoma: a case report and review of the literature. Eur J Radiol1996232138–142
7.
Rado VelázquezMACorreas GómezMAMartín GarcíaB. (Synchronous renal oncocytoma and asymptomatic pheochromocytoma. Report of a case). Arch Esp Urol2001548816–819
8.
BahramiATruongLDShenSSKrishnanBSynchronous renal and adrenal masses: an analysis of 80 cases. Ann Diagn Pathol20091319–15
9.
HendersonADouglasFPerrosPMorganCMaherERSDHB-associated renal oncocytoma suggests a broadening of the renal phenotype in hereditary paragangliomatosis. Fam Cancer200983257–260
10.
Comino-MéndezIGracia-AznárezFJSchiaviF. Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma. Nat Genet2011437663–667
11.
KorpershoekEKoffyDEussenBH. Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis. J Clin Endocrinol Metab20161012453–460
