TO report the anatomic and functional outcome of intravitreal bevacizumab (IVB) to treat choroidal neovascularization (CNV) following photodynamic therapy (PDT) to treat recurrent central serous choroidopathy (CSC).
Methods
This was an interventional case report in which verteporfin PDT was performed in a case of recurrent CSC.
Results
Following PDT, the patient developed juxtafoveal CNV that was later treated by IVB, achieving CNV closure and recovery of visual acuity.
Conclusions
Photodynamic therapy is a useful therapy to treat recurrent CSC, though it may be associated with potentially severe complications such as CNV. Intravitreal bevacizumab seems a good alternative treatment in the management of this condition.
Ruiz-MorenoJ.M., LugoF.L., ArmadaF.Photodynamic therapy for chronic central serous chorioretinopathy. Acta Ophthalmol2010; 88: 371–6.
2.
YamanA., ArikanG., SaatciA.O., CingilG.Choroidal neovascularization following photodynamic therapy in a patient with chronic central serous chorioretinopathy. Bull Soc Belge Ophtalmol2007; 303: 69–73.
3.
ChanW.M., LaiT.Y., LaiR.Y., LiuD.T., LamD.S.Half-dose verteporfin photodynamic therapy for acute central serous chorioretinopathy: one-year results of a randomized controlled trial. Ophthalmology2008; 115: 1756–65.
4.
LeeP.Y., KimK.S., LeeW.K.Severe choroidal ischemia following photodynamic therapy for pigment epithelial detachment and chronic central serous chorioretinopathy. Jpn J Ophthalmol2009; 53: 52–6.
5.
KimS.W., OhJ., OhI.K., HuhK.Retinal pigment epithelial tear after half fluence PDT for serous pigment epithelial detachment in central serous chorioretinopathy. Ophthalmic Surg Lasers Imaging2009; 40: 300–3.
6.
Schmidt-ErfurthU., MillerJ.W., SickenbergM.Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration: results of retreatments in a phase 1 and 2 study. Arch Ophthalmol1999; 117: 1177–87.
7.
DebefveE., ChengC., SchaeferS.C.Photodynamic therapy induces selective extravasation of macromolecules: insights using intravital microscopy. J Photochem Photobiol B2010; 98: 69–76.
8.
TatarO., AdamA., ShinodaK.Influence of verteporfin photodynamic therapy on inflammation in human choroidal neovascular membranes secondary to age-related macular degeneration. Retina2007; 27: 713–23.
9.
ParodiM.B., laconoP., KontadakisD.S., ZucchiattiI., CascavillaM.L., BandelloF.Bevacizumab vs photodynamic therapy for choroidal neovascularization in multifocal choroiditis. Arch Ophthalmol2010; 128: 1100–3.
10.
HayashiK., Ohno-MatsuiK., ShimadaN.Intravitreal bevacizumab on myopic choroidal neovascularization that was refractory to or had recurred after photodynamic therapy. Graefes Arch Clin Exp Ophthalmol2009; 247: 609–18.
