The Impact of Acupuncture Treatment on Nitric Oxide (NO) in Migraine Patients

Abstract

The purpose of this study is to contribute to efforts to understand the pathophysiology of migraine and create an alternative perspective for prophylaxis and treatment of migraine attacks. Acupuncture treatment was applied to the 22 volunteer migraine patients. The acupuncture treatment consists of 5 sessions with 2 sessions per week. Blood samples have been collected before performing acupuncture, after the 1st session and after the 5th session of the acupuncture. And for the control group blood samples were collected only once. In our study the mean serum NO levels in healthy people were (3,58±0,53) while patients with migraine group were (5,55±0,70) respectively. Serum NO levels were 55% higher in migraine group compared to the control group The NO concentration also decreased after 5th session (30%) (p<0.05). After the 1st sessions NO level decreased 4,86% in the migraine group. After the 5th session NO level decreased 30,63% in the migraine group. After the 5th session NO level decreased 27,08% compared to 1st session in the migraine group. After the 1st session of acupuncture treatment, level of NO in migraine group were 4,86% and it is reduced but statistically not significant. After the 5th acupuncture treatment serum NO levels were reduced to (3,85±0.62) 30,63% in migraine group and were statistically lower (p<0.05). After the 5th session NO level decreased 27,08% compared to 1st session in the migraine group. In this study, acupuncture treatment is appeared to be effective by lowering the levels of serum NO and acupuncture has cumulative effects. Although there are earlier studies showing the effect of NO in migraine, this has been the 1st study in this field, which shows the effect of acupuncture on NO in migraine patients.

Keywords

MIGRAINE ACUPUNCTURE NITRIC OXIDE COMPLEMENTARY THERAPIES FREE RADICALS NITRATE NITRITE

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References

Headache Classification Commitee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralglas and facial pain. Cephalojia Vol. 8(suppl 7), pp.1–96, 1988.

Steven

Nitric Oxide: Pathophysiological mechanisms. Annual Review of PhysiologyVol.57, pp. 737–769, 1995.

Nitrate/ Nitrite Colorimetric Assay Kit, Nitric oxcide synthetase, Cayman Chemical Company USA, Catalog No. 780001, pp. 4. 2009.

K.W

. Acupuncture: Its place in the History of Chinese Medicine. Acupuncture in Medicine. Vol. 18(2), pp. 88–99, 2004.

Hopwood

Lovesey

Mokone

Acupuncture & related techniques in physical therapy. Elsevier Science Ltd, London UK. 2003.

Ellis

Acupuncture in clinical practice. A guide for health professionals. Stanley Thornes Ltd, Bath UK, 2000.

Severcan

Cevik

Acar

Sivri

Mit

Geçioglu

Pasaoglu

Gündüztepe

The effects of acupuncture on the levels of blood pressure and nitric oxide in hypertensive patients. Acupuncture & Electrotherapeutic Research, International Journal of Integrated Medicine.Vol. 37, pp. 263–275, 2012.

D'Andrea

Cananzi

A.R.

Perini

Decreased collagen - induced platelet aggregation and increased arginin levels in migraine: a possible link with the NO pathway. Cephalalgia. Vol. 14, pp. 352–357, 1994.

Olesen

Iversen

, K., Thomsen, L. Nitric oxide supersensitivity A possible molecular mechanism of migraine pain. Neuroreport. Vol. 4, pp. 1027–1030, 1993.

10.

Olesen

Thomsen

Lassen

Jansen

The nitric oxide hypothesis of migraine and other vascular headaches. Cephalalgia. Vol.15, pp. 94–100, 1995.

11.

Nattero

Nitric oxide, endothelin-1 and transcranial Doppler in migraine. Findings in interictal conditions and during mig raine attack. Headache. Vol. 36, pp. 307–311, 1996.

12.

Griffiths

L.R

. Migraine association and linkage studies of an endothelial nitric oxide synthase (NOS3) gene polymorphism. Neurology. Vol. 49, pp. 614–617, 1997.

13.

Castellano

A.E.

Micelli

Bellatonie

Indomethacin increases the effect of isosorbide dinitrate on cerebral hemodynamics in migraine patients. Cephalalgia. Vol.18, pp. 622–630, 1998.

14.

Iversen

H.K.

, Holm

, Friberg, L. Intracranial hemodynamics during intravenous nitroglyserin infussion. Cephalalgia. Vol.11, pp. 183–188, 1989.

15.

Pintov

Lahat

Alstein

Vogel

Bar

Acupuncture and the opioid system: Implications in management of migraine. Pediatric Neurology. Vol.17 pp. 129–133, 1997.

16.

Ahonen

Hakumaki

Pantanen

Riekkinnen

Sivenius

Effectiveness of acupuncture and physiotherapy on myogenicheadache: A comperative study. Acupuncture & Electrotherapeutic Research. Vol. 9, pp. 141–150, 1984.

17.

Nattero

Nitric oxide, endothelin-1 and transcranial Doppler in migraine. Findings in interictal conditions and during mig raine attack. Headache. Vol. 36, pp. 307–311, 1996.

18.

Iversen

K. Holm S, Friberg L. Intracranial hemodynamics during intravenous nitroglyserin infussion. Cephalalgia. Vol, 11, pp. 183–188, 1989.

19.

Suzuki

Nakaki

Nakamura

Miyaoka

Plasma nitrate levels in deficit versus non-deficit forms of schizophrenia. Psychiatry & Neuroscience. Vol. 28, pp. 288–292, 2003.

20.

D'Amico

Ferraris

Leone

Catania

Carlin

Grazzi

Increased plasma nitrite in migraine and cluster headache patients in interictal period: basal hyperactivity of L-Arginine-NO pathway? Cephalalgia. Vol. 22, pp. 33–36, 2002.

21.

Ceccherelli

Lovato

Piana

Gagliardi

Roveri

Antonella. A Somatic acupuncture versus ear ackupuncture in migraine therapy a randomized, controlled, blind therapy. Acupuncture & Electrotherapeutic Research, International Journal of Integrated Medicine. Vol. 37, pp. 277–293, 2012.