The Central Mechanism of the Depressor-Bradycardia Effect of “Tinggong(SI 19)-Quchi(LI 11)” 2Hz-Electroacupuncture

Abstract

Roles of central adrenergic receptors and opoid receptors in the depressor-bradycardia effect of 3V, 2Hz “ Tinggong-Quchi “ electroacupuncture (the EA-DpB, i.e.the depressor bradycardia induced by electroacupuncture) were studied by intracerebroventricula (icv) injection of prazosin, yohimbin or propranol, naloxone or by intra-arachnoid (ith) injection of naloxone. Voltage-dependent depressor effects were induced by 2Hz “Tinggong-Quchi” acupuncture. The depressor effect of 3V, 2Hz “ Tinggong-Quchi “ acupuncture was attenuated by icv injection of a β-receptor antagonist-propranalol, but was not blocked by the icv injection of an ±₁ -or (±₂ -receptor antagonist prazosin or yohimbin. lev injected naloxone but not ith injected naloxone blocked or reversed the EA-DpB. Results suggest that central P-receptors or opoid receptors in the brain are selectively involved in the EA-DpB.

Keywords

the depressor-bradycardia effect electroacupuncture naloxone prazosin yohimbin propranol

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