Evaluation of an MRI-Based Protocol for Cell Implantation in Four Patients with Huntington's Disease

Alexander G. E. ; Crutcher M. D. Functional architecture of basal ganglia circuits: Neural substrates of parallel processing [see comments]. Trends Neurosci. 13: 266–271; 1990.

Alexander G. E. ; Crutcher M. D. ; DeLong M. R. Basal ganglia–thalamocortical circuits: Parallel substrates for motor, oculomotor, “prefrontal” and “limbic” functions. Prog. Brain Res. 85: 119–146; 1990.

Bachoud-Lévi A. ; Bourdet C. ; Brugières P. ; Nguyen J. P. ; Grandmougin T. ; Haddad B. ; Jény R. ; Bartolomeo P. ; Boissé M. F. ; Barba G. D. ; Degos J. D. ; Ergis A. M. ; Lefaucheur J. P. ; Lisovoski F. ; Pailhous E. ; Rémy P. ; Palfi S. ; Defer G. L. ; Césaro P. ; Hantraye P. ; Peschanski M. Safety and tolerability assessment of intrastriatal neural allografts in five patients with Huntington's disease. Exp. Neurol. 161(1): 194–202; 2000

Bachoud-Lévi A. C. ; Rémy P. ; Nguyen J. P. ; Brugières P. ; Lefaucheur J. P. ; Bourdet C. ; Baudic S. ; Gaura V. ; Maison P. ; Haddad B. ; Boissé M. F. ; Grandmougin T. ; Jény R. ; Bartolomeo P. ; Dalla B. G. ; Degos J. D. ; Lisovoski F. ; Ergis A. M. ; Pailhous E. ; Césaro P. ; Hantraye P. ; Peschanski M. Motor and cognitive improvements in patients with Huntington's disease after neural transplantation. Lancet 356(9246): 1975–1979; 2000.

Bizzi A. ; Brooks R. A. ; Brunetti A. ; Hill J. M. ; Alger J. R. ; Miletich R. S. ; Francavilla T. L. ; Di Chiro G. Role of iron and ferritin in MR imaging of the brain: A study in primates at different field strengths. Radiology 177: 59–65; 1990.

Björklund A. ; Campbell K. ; Sirinathsinghji D. J. S. ; Fricker R. A. ; Dunnett S. B. Functional capacity of striatal transplants in the rat Huntington model. In: Dunnett S. B. ; Björklund A. , eds. Functional neural transplantation. New York: Raven Press; 1994: 157–195.

Brundin P. ; Barbin G. ; Strecker R. E. ; Isacson O. ; Prochiantz A. ; Björklund A. Survival and function of dissociated dopamine neurons grafted at different developmental stages or after being cultured in vitro. Dev. Brain Res. 39: 233–243; 1988.

Brundin P. ; Isacson O. ; Björklund A. Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival. Brain Res. 331: 251–259; 1985.

Defer G. L. ; Geny C. ; Ricolfi F. ; Fenelon G. ; Monfort J. C. ; Remy P. ; Villafane G. ; Jény R. ; Samson Y. ; Keravel Y. ; Gaston A. ; Degos J. D. ; Peschanski M. ; Césaro P. ; Nguyen J. P. Long-term outcome of unilaterally transplanted parkinsonian patients. I. Clinical approach. Brain 119: 41–50; 1996.

Denys A. ; Leroy-Willig A. ; Riche D. ; Hantraye P. MR appearance of neural grafts in a primate model of Huntington disease. Am. J. Roentgenol. 158: 215–216; 1992.

Donovan T. ; Fryer T. D. ; Carpenter T. A. ; Antoun N. M. ; Gillard J. H. ; Watts C. ; Pickard J. D. Stereotactic MR imaging for planning neural transplantation. A reliable technique at 3T? J. Neurosurg. in press.

Dunnett S. B. ; Björklund A. Functional neural transplantation. New York: Raven Press; 1994.

Dunnett S. B. Functional repair of striatal systems by neural transplants: evidence for circuit reconstruction. Behav. Brain Res. 66: 133–142; 1995.

Dunnett S. B. ; Isacson O. ; Sirinathsinghji D. J. S. ; Clarke D. J. ; Björklund A. Striatal grafts in rats with unilateral striatal lesions. III. Recovery from dopamine dependent motor asymmetry and deficits in skilled paw reaching. Neuroscience 24: 813–820; 1988.

Dunnett S. B. ; Kendall A. L. ; Watts C. ; Torres E. M. Neuronal cell transplantation for Parkinson's and Huntington's diseases. Br. Med. Bull. 53: 757–776; 1997.

Folkerth R. D. ; Durso R. Survival and proliferation of nonneural tissues, with obstruction of cerebral ventricles, in a parkinsonian patient treated with fetal allografts [see comments]. Neurology 46: 1219–1225; 1996.

Freed W. Transplantation of tissue to the cerebral ventricles: Methodological details and rate of graft survival. In: Björklund A. ; Stenevi U. , eds. Neural grafting in the mammalian central nervous system. Amsterdam: Elsevier; 1985: 31–40.

Fricker R. A. ; Barker R. A. ; Fawcett J. W. ; Dunnett S. B. A comparative study of preparation techniques for improving the viability of striatal grafts using vital stains, in vitro cultures and in vivo grafts. Cell Transplant. 5: 599–611; 1996.

Fricker R. A. ; Torres E. M. ; Dunnett S. B. The effects of donor age on the survival and function of embryonic striatal grafts in the ibotenic acid lesioned adult rats striatum. I. Morphological analysis. Neuroscience 79: 695–710; 1997.

Fricker R. A. ; Torres E. M. ; Hume S. P. ; Myers R. ; Opacka-Juffery J. ; Ashworth S. ; Brooks D. J. ; Dunnett S. B. The effect of donor age on the survival and function of embryonic striatal grafts in the adult rat brain II. Correlation between positron emission tomography and reaching behaviour. Neuroscience 79: 711–721; 1997.

Hurelbrink C. ; Tyers P. ; Armstrong R. J. E. ; Dunnett S. B. ; Barker R. A. ; Rosser A. E. Long-term hibernation of human fetal striatal tissue does not adversely affect its differentiation in vitro or graft survival: Implications for clinical trials in Huntington's disease. Cell Transplant. 12: 687–695; 2003.

Isacson O. ; Dunnett S. B. ; Björklund A. Graft-induced behavioral recovery in an animal model of Huntington's disease. Proc. Natl. Acad. Sci. USA 83: 2728–2732; 1986.

Kendall A. L. ; Rayment F. ; Torres E. M. ; Baker H. ; Ridley R. ; Dunnett S. B. Functional integration of striatal allografts in a primate model of Huntington's disease. Nat. Med. 4: 727–729; 1998.

Kopyov O. V. ; Jacques D. ; Lieberman A. ; Duma C. ; Rogers R. Outcome following intrastriatal fetal mesencephalic grafts for Parkinson's patients is directly related to the volume of grafted tissue. Exp. Neurol. 146: 536–545; 1997.

Kopyov O. V. ; Jacques S. ; Lieberman A. ; Duma C. ; Eagle K. S. Safety of intrastriatal neurotransplantation for Huntington's disease patients. Exp. Neurol. 149: 97–108; 1998.

Lindvall O. ; Rehncrona S. ; Brundin P. ; Gustavii B. ; Astedt B. ; Widner H. ; Lindholm T. ; Björklund A. ; Leenders K. L. ; Rothwell J. C. Human fetal dopamine neurons grafted into the striatum in two patients with severe Parkinson's disease. A detailed account of methodology and a 6-month follow-up. Arch. Neurol. 46: 615–631; 1989.

Lindvall O. ; Sawle G. ; Widner H. ; Rothwell J. C. ; Björklund A. ; Brooks D. ; Brundin P. ; Frackowiak R. ; Marsden C. D. ; Odin P. Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann. Neurol. 35: 172–180; 1994.

Lindvall O. ; Widner H. ; Rehncrona S. ; Brundin P. ; Odin P. ; Gustavii B. ; Frackowiak R. ; Leenders K. L. ; Sawle G. ; Rothwell J. C. Transplantation of fetal dopamine neurons in Parkinson's disease: One-year clinical and neurophysiological observations in two patients with putaminal implants. Ann. Neurol. 31: 155–165; 1992.

Mamelak A. N. ; Eggerding F. A. ; Oh D. S. ; Wilson E. ; Davis R. L. ; Spitzer R. ; Hay J. A. ; Caton W. L. Fatal cyst formation after fetal mesencephalic allograft transplant for Parkinson's disease. J. Neurosurg. 89: 592–598; 1998.

Nakao N. ; Grasbon-Frodl E. M. ; Widner H. ; Brundin P. DARPP-32-rich zones in grafts of lateral ganglionic eminence govern the extent of functional recovery in skilled paw reaching in an animal model of Huntington's disease. Neuroscience 74: 959–970; 1996.

Norman A. B. ; Thomas S. R. ; Pratt R. G. ; Lu S. Y. ; Norgren R. B. Magnetic resonance imaging of neural transplants in rat brain using a superparamagnetic contrast agent. Brain Res. 594: 279–283; 1992.

Norman A. B. ; Thomas S. R. ; Pratt R. G. ; Samaratunga R. C. ; Sanberg P. R. A magnetic resonance imaging contrast agent differentiates between the vascular properties of fetal striatal tissue transplants and gliomas in rat brain in vivo. Brain Res. 503: 156–159; 1989.

Norman A. B. ; Thomas S. R. ; Pratt R. G. ; Samaratunga R. C. ; Sanberg P. R. Magnetic resonance imaging of rat brain following kainic acid-induced lesions and fetal striatal tissue transplants. Brain Res. 483: 188–191; 1989.

Norman A. B. ; Thomas S. R. ; Pratt R. G. ; Samaratunga R. C. ; Sanberg P. R. T1 and T2 weighted magnetic resonance imaging of excitotoxin lesions and neural transplants in rat brain in vivo. Exp. Neurol. 109: 164–170; 1990.

Palfi S. ; Conde F. ; Riche D. ; Brouillet E. ; Dautry C. ; Mittoux V. ; Chibois A. ; Peschanski M. ; Hantraye P. Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease. Nat. Med. 4: 963–966; 1998.

Palfi S. ; Nguyen J. P. ; Brugieres P. ; Le Guerinel C. ; Hantraye P. ; Rémy P. ; Rostaing S. ; Defer G. L. ; Césaro P. ; Keravel Y. ; Peschanski M. MRI-stereotactical approach for neural grafting in basal ganglia disorders. Exp. Neurol. 150: 272–281; 1998.

Palfi S. ; Nguyen J. P. ; Brugières P. ; Le Guerinel C. ; Hantraye P. ; Rémy P. ; Rostaing S. ; Defer G. L. ; Césaro P. ; Keravel Y. ; Peschanski M. MRI-stereotactical approach for neural grafting in basal ganglia disorders. Exp. Neurol. 150: 272–281; 1998.

Peschanski M. ; Césaro P. ; Hantraye P. Rationale for intrastriatal grafting of striatal neuroblasts in patients with Huntington's disease. Neuroscience 68: 273–285; 1995.

Peschanski M. ; Defer G. ; N'Guyen J. P. ; Ricolfi F. ; Monfort J. C. ; Rémy P. ; Geny C. ; Samson Y. ; Hantraye P. ; Jény R. Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon. Brain 117: 487–499; 1994.

Quarrell O. ; Harper P. The clinical neurology of Huntington's disease. In: Harper P. , ed. Huntington's disease. London: W. B. Saunders; 1996: 31–72.

Quinn N. ; Brown R. ; Craufurd D. ; Goldman S. ; Hodges J. ; Kieburtz K. ; Lindvall O. ; MacMillan J. ; Roos R. Core Assessment Program for Intracerebral Transplantation in Huntington's Disease (CAPIT-HD). Mov. Disord. 11: 143–150; 1996.

Rosser A. E. ; Barker R. A. ; Harrower T. C. ; Watts C. ; Farrington R. M. ; Burnstein A. K. ; Gillard J. H. ; Pickard J. D. ; Dunnett S. B. Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report. J. Neurol. Neurosurg. Psychiatry 73: 678–685; 2002.

Sanberg P. R. ; Giordano M. ; Henault M. A. ; Nash D. R. ; Ragozzino M. E. ; Hagenmeyer-Hauser S. H. Intraparenchymal striatal transplants required for maintenance of behavioural recovery in an animal model of Huntington's disease. J. Neural Transplant. Plast. 1: 23–31; 1989.

Studholme C. ; Hawkes D. J. ; Hill D. J. G. Automated 3D registration of MR and CT images of the head. Med. Image Analysis 1: 163–175; 1996.

Watts C. ; Brasted P. ; Dunnett S. B. The morphology, integration and functional efficacy of striatal grafts differs between cell suspensions and tissue pieces. Cell Transplant. 9: 395–407; 2000.

Watts C. ; Brasted P. ; Eagle D. ; Dunnett S. B. Embryonic donor age and dissection influences striatal graft development and functional integration in a rodent model of Huntington's disease. Exp. Neurol. 1999.

Watts C. ; Dunnett S. B. Effects of severity of host striatal damage on the morphological development of intrastriatal transplants in a rodent model of Huntington's disease: Implications for timing of surgical intervention. J. Neurosurg. 89: 267–274; 1998.

Watts C. ; McNamara I. ; Dunnett S. B. Volume and differentiation of striatal grafts in rats: Relationship to the number of cells implanted. Cell Transplant. 9: 65–72; 2000.

Watts C. ; Dunnett S. B. Towards a protocol for the preparation and delivery of striatal tissue for clinical trials of transplantation in Huntington's disease. Cell Transplant. 9: 223–234; 2000.

Wirth E. D. ; Theele D. P. ; Mareci T. H. ; Anderson D. K. ; Brown S. A. ; Reier P. J. In vivo magnetic resonance imaging of fetal cat neural tissue transplants in the adult cat spinal cord. J. Neurosurg. 76: 261–274; 1992.