Review: Signal transduction mechanisms of the angiotensin II type AT1-receptor: looking beyond the heterotrimeric G protein paradigm

Duncia JV , Carini DJ , Chiu AT et al. The discovery of Dup753, a potent, orally active nonpeptide Ang II receptor antagonist. Med Res Rev 1992;12:149-91.

Chiu AT , McCall DE , Nguyen TT et al. Discrimination of Ang II receptor subtypes by dithiothreitol . Eur J Pharm 1989;170:117-8.

Wong PC , Price WA , Chiu AT et al. In vivo pharmacology of Dup753. Am J Hypertens 991;4:S288-98.

Timmermans Pbmwm , Wong PC , Chiu AT et al. Ang II receptors and Ang II receptor antagonists. Pharm Rev 1993;45:205-51.

Ondetti MA , Rubin B. , Cushman DW Design of specific inhibitors of angiotensin-converting enzyme: new class of orally active anti-hypertensive agents. Science 1977;196:441-4.

Teerlink JR The evolving role of angiotensin-converting enzyme inhibition in heart failure: expanding the protective envelope.J Cardiovasc Pharmacol 1994;24:S32-7.

Fouad-Tarazi FM Hemodynamic effects of inhibitors of the renin-angiotensin system. J Hypertension 1994;12:S25-S29.

Daemen MJ , Lombardi DM , Bosman FT , Schwartz SM Ang II induces smooth muscle proliferation in the normal and injured rat arterial wall. Circ Res 1991;68:450-6.

The Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting enzyme inhibitor, ramipril, on death from cardiovascular causes, myocardial infarction, and stroke in high risks patients. New Engl J Med 2000;342:145-53.

The Heart Outcomes Prevention Evaluation Study Investigators. Vitamin E supplementation and cardiovascular events in high risk patients. New Engl J Med 2000;342:154-60.

Regan CP , Bishop SP , Berecek KH Early, short-term treatment with captopril permanently attenuates cardiovascular changes in spontaneously hypertensive rats. Clin Exp Hypertens 1997;19:1161-77.

Katovich MJ , Gelband CH , Reaves PY , Wang HW , Raizada MK Reversal of hypertension by Ang II type 1 receptor antisense gene in the adult spontaneously hypertensive rat. Amer J Physiol 1999;277:H1260-4.

Reaves PY , Gelband CH , Wang HW et al. Permanent cardiovascular protection from hypertension by the AT1 receptor antisense gene therapy in hypertensive rat offspring. Circ Res 1999;85:44-50.

Pachori AS , Wang HW , Gelband CH , Ferrario CM , Katovich MJ , Raizada MK Inability to induce hypertension in normotensive rat expressing AT1 receptor antisense. Circ Res 2000;86:1167-72.

Katz AM Is Ang II a growth factor masquerading as a vasopressor? Heart Dis Stroke 1992;1:151-4.

Powell JS , Clozel JP , Muller RK , Kuhn H. , Hefti F. , Hosang M. Inhibitors of angiotensin converting enzyme prevent myointimal proliferation after vascular injury. Science 1989;245:186-8.

Chiu AT , Roscoe WA , McCall DE , Timmermans Pbmwm. Ang II type-1 receptors mediate both vasoconstrictor and hypertrophic responses in rat aortic smooth muscle cells. Receptors 1991;1:133-40.

Hein L. , Stevens ME , Barsh GS , Pratt RE , Kobilka BK , Dzau VJ Over expression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. Proc Natl Acad Sci (USA) 1997;94:6391-6.

Paradis P. , Dali-Youcef N. , Paradis FW , Thibault G. , Nemer M. Overexpression of Ang II type 1 receptor in cardiac myocytes induces cardiac hypertrophy and remodeling. Proc Natl Acad Sci (USA) 2000;97:931-6.

Pawson T. New impressions of Src and Hck. Nature 1997 ;385:582-3.

Sasaki K. , Yamano Y. , Bardhan S. et al. Cloning and expression of a complementary cDNA encoding a bovine adrenal Ang II type-1 receptor.Nature 1991 ;351:230-2.

Murphy TJ , Alexander RW , Griendling KK , Runge MS , Bernstein KE Isolation of a cDNA encoding the vascular type-1 Ang II receptor. Nature 1991;351:233-6.

Dhar A. , Shukla SD Electrotransjection of pp60v-src monoclonal antibody inhibits activation of phospholipase C in platelets. J Biol Chem 1994;269:9123-7.

Erpel T. , Courtneidge SA Src family protein tyrosine kinases and cellular signal transduction . Curr Opin Cell Biol 1995;7:176-82.

Peeler TC , Conrad KM , Baker KM Endothelin stimulates sis-inducing factor-like DNA binding activity in CHO-K1 cells expressing ETA receptors. Biochem Biophys Res Comm 1996;221:62-6.

Buggy JJ Binding of α-melanocyte-stimulating hormone to its G protein-coupled receptor on B-lymphocytes activates the Jak/STAT pathway. Biochem J1998; 331:211-6.

Luttrell LM , Ferguson SSG , Daaka Y. et al. β-arrestin dependent formation of β2 adrenergic receptor-Src protein kinase complexes . Science 1999;283:655-61.1.

Sasaguri T. , Teruya H. , Ishida A. , Abumiya T. , Ogata J. Linkage between α1 adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells. Biochem Biophys Res Comm 2000 ;268:25-30.

Zhong H. , Murphy TJ , Minneman KP Activation of signal transducers and activators of transcription by α1A-adrenergic receptor stimulation in PC12 cells. Mol Pharm 2000;5:961-7.

Marrero MB , Scheiffer B. , Paxton WG et al. Direct stimulation of Jak/STAT pathway by the Ang II AT1 receptor . Nature 1995;375:247-50.

Sadoshima J. , Izumo S. The heterotrimeric Gγ protein-coupled Ang II receptor activates p21ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. EMBO J 1996;15:775-87.

Ishida M. , Marrero MB , Schieffer B. , Ishida T. , Bernstein KE , Berk BC Ang II activates pp60c-src in vascular smooth muscle cells. Circ Res 1995;77:1053-9.

Li X. , Earp HS Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent tyrosine kinase in rat liver epithelial cells. J Biol Chem 1997;272:14341-8.

Ali MS , Sayeski PP , Dirksen LB , Hayzer DJ , Marrero MB , Bernstein KE Dependence of the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the Ang II AT1 receptor. JBiol Chem 1997;272:23382-8.

Murakami M. , Narazaki M. , Hibi M. et al. Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor superfamily.Proc Natl Acad Sci (USA) 1991 ;88:11349-53.

Zhu YX , Sun HB , Tsang MLS et al. Critical cytoplasmic domains of the human interleukin-9 receptor α chain in interleukin-9-mediated cell proliferation and signal transduction . J Biol Chem 1997;272:21334-40.

Ali MS , Sayeski PP , Bernstein KE Jak2 acts as both a STAT1 kinase and as a molecular bridge linking STAT1 to the angiotensin II AT1 receptor. J Biol Chem 2000;275:15586-93.

Sayeski PP , Ali MS , Safavi A. et al. A catalytically active Jak2 is required for the Ang II-dependent activation of Fyn. J Biol Chem 1999;274:33131-42.

Ali MS , Sayeski PP , Safavi A. , Lyles M. , Bernstein KE Janus kinase 2 (Jak2) must be catalytically active to associate with the AT1 receptor in response to Ang II. Biochem Biophys Res Comm 1998;249:672-7.

Taubman MB , Berk BC , Izumo S. , Tsuda T. , Alexander RW , Nadal-Ginard B. Ang II induces c-fos mRNA in aortic smooth muscle cells. JBiol Chem 1989;264:526-30.