Source intensity optimization in quantitative three-dimensional diffuse optical tomography

Abstract

We present a method that optimizes the source intensity distribution in three-dimensional (3D) diffuse optical tomography (DOT). We evaluate this method using a series of phantom experiments where different contrast levels between the target and background are considered. With the new method, while the quality of both absorption and scattering images is quantitatively improved, the improvement in absorption image reconstruction is especially substantial: a relative error of less than 0.95% for recovered peak value in the target region is achieved for high contrast case and of less than 18.0% for low contrast case.