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Abstract

BACKGROUND:

This study aimed to investigate the effects of the Kidney-Tonifying and Blood-Activating Formula on combating the downregulation of integrin $\beta$ 3 and integrin $\beta$ 5 in mouse placental tissue induced by phospholipid antibodies.

OBJECTIVE:

This study aimed to investigate the effects of kidney-tonifying and blood-activating formulations on combating the downregulation of integrin $\beta$ 3 and integrin $\beta$ 5 in mouse placental tissue induced by phospholipid antibodies.

METHODS:

Mice in the phospholipid antibody group and phospholipid antibody $+$ kidney-tonifying and blood-activating formula group underwent repeated implantation experiments, and the expression of integrin $\beta$ 3 and integrin $\beta$ 5 in placental tissue was observed. The effects of the kidney-tonifying and blood-activating formula on mouse placental tissue were evaluated through biochemical index tests, histopathological observations, and immunohistochemical staining.

RESULTS:

After intervention with the kidney-tonifying and blood-activating formula, the expression of integrin $\beta$ 3 and integrin $\beta$ 5 in placental tissue was notably upregulated, and placental structure was restored. Kidney-Tonifying and Blood-Activating Formula significantly improved abnormal biochemical indices and exerted a remarkable protective effect on placental tissue pathology.

CONCLUSION:

The kidney-tonifying and blood-activating formula effectively counteracted the downregulation of integrin $\beta$ 3 and integrin $\beta$ 5 in mouse placental tissue induced by phospholipid antibodies and alleviated placental tissue pathology through structural improvement and protection. Therefore, kidney-tonifying and blood-activating formulas may serve as potential therapeutic agents for recurrent implantation failure, offering new insights and approaches for clinical treatment.

Keywords

Kidney-tonifying and blood-activating formula phospholipid antibodies recurrent implantation failure placental tissue integrin β3 integrin β5

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Effects of Bushen Huoxue on integrin β 3 and integrin β 5 in the placental tissue of mice with repeated implantation failure caused by phospholipid antibodies

Abstract

BACKGROUND:

OBJECTIVE:

METHODS:

RESULTS:

CONCLUSION:

Keywords

Get full access to this article

References