Analysis of the relationship between mild cognitive impairment and serum klotho protein and insulin-like growth factor-1 in the elderly

Abstract

BACKGROUND:

Mild cognitive impairment (MCI) is a mild memory or cognitive impairment.

OBJECTIVE:

To explore the relationship between serum klotho (K1) protein and insulin-like growth factor-1 and mild cognitive impairment in the elderly in order to provide accurate and appropriate indicators for clinical diagnosis and treatment of MCI.

METHODS:

This randomized stratified study adopted a multistage cluster sampling method. 161 elderly patients with mild cognitive impairment were included as the MCI group, and 161 healthy people matched with the MCI group in gender, age and education were selected as the control group.

RESULTS:

The levels of serum K1 protein and insulin-like growth factor-1 in the MCI group were lower than those in the control group ( $P<$ 0.05). Both IGF-1 and K1 had predictive value for MCI ( $P<$ 0.05). The area under the curve (AUC) of IGF-1 for predicting MCI was 0.859 (95% CI: 0.790 $\sim$ 0.929), and the AUC of K1 for predicting MCI was 0.793 (95% CI: 0.694 $\sim$ 0.892). The value of joint prediction of the two indicators was the highest, with an AUC of 0.939 (95% CI: 0.896–0.993).

CONCLUSION:

High serum K1 and insulin-like growth factor-1 are the protective factors of cognitive impairment in MCI patients. Both IGF-1 and serum K1 proteins have predictive value for MCI, and the combination of the two indicators has the highest predictive value.