Treadmill exercise training could attenuate the upregulation of Interleukin-1 beta and tumor necrosis factor alpha in the skeletal muscle of mouse model of chronic/progressive Parkinson disease
Restricted accessResearch articleFirst published online January 2, 2019
Treadmill exercise training could attenuate the upregulation of Interleukin-1 beta and tumor necrosis factor alpha in the skeletal muscle of mouse model of chronic/progressive Parkinson disease
Induction of Parkinson disease (PD) causes interleukin-1 beta (IL-1β) and tumor
necrosis factor-alpha (TNF-α) upregulation in gastrocnemius skeletal muscles. Endurance
exercise suppresses iNOS and HSP90 overexpression in PD skeletal muscle. The purpose of
this study is to test the impact of treadmill exercise training on PD-associated IL-1β
and TNF-α upregulation in the gastrocnemius muscle.
METHODS:
Thirty normal albino mice were randomly selected and divided into three equal groups:
sedentary control (SC), sedentary PD (SPD), and Exercised PD (EPD). Chronic Parkinsonism
was induced by treating mice in the SPD and EPD groups with
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probenecid (MPTP/p). Gastrocnemius
muscles were examined for the expression of IL-1β and TNF-α using
immunohistochemistry in the three different groups.
RESULTS:
Endurance exercise training significantly decreased both IL-1β and
TNF-α expression in skeletal muscle in EPD (P
value < 0.01) compared with that in the SPD.
CONCLUSION:
Our present data suggest that PD-induced upregulation of IL-1β and
TNF-α in the gastrocnemius muscle could be reversed following
endurance exercise training. Accordingly, IL-1β and TNF-α might be
considered therapeutically to ameliorate skeletal muscle abnormalities characterizing
PD.
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