The Impact of Deep Brain Stimulation on Sleep in Parkinson’s Disease: An update

Abstract

Background:

Parkinson’s disease (PD) can have a significant impact on sleep. Deep brain stimulation (DBS) is an effective treatment for motor features of PD, but less is understood about the impact DBS may have on sleep architecture and various sleep issues commonly seen in PD.

Objective:

To review the impact of DBS on various sleep issues in PD.

Methods:

We reviewed the literature regarding the impact of DBS on sleep patterns, nocturnal motor and non-motor symptoms, and sleep disorders in PD.

Results:

Objective sleep measures on polysomnography (PSG), including sleep latency and wake after sleep onset improve after subthalamic nucleus (STN) and globus pallidus interna (GPi) DBS. Subjective sleep measures, nocturnal motor symptoms, and some non-motor symptoms (nocturia) also may improve. Current evidence suggests STN DBS has no impact on Rapid Eye Movement Behavior Disorder (RBD), while STN DBS may improve symptoms of Restless Legs Syndrome (RLS). There are no studies that have evaluated the impact of GPi DBS on RBD, while it is unclear if GPi has an effect on RLS in PD.

Conclusion:

DBS therapy at either site appears to improve objective and subjective sleep parameters in patients with PD. Most likely, the improvement of motor and some non-motor nocturnal symptoms leads to an increase in total sleep time by up to an hour, as well as reduction of sleep fragmentation. DBS most likely has no impact on RBD, while there is evidence that STN DBS appears to help reduce RLS severity. Further studies are needed.

Keywords

Deep brain stimulation Parkinson’s disease sleep rapid eye movement behavior disorder restless legs syndrome

INTRODUCTION

Parkinson’s disease (PD) is a neurodegenerative disorder that is typically characterized by progressive rest tremor, bradykinesia, rigidity and gait instability. Non-motor features are often just as disabling as the motor features and can precede the clinical diagnosis of PD by many years [1]. Sleep disturbances are common in PD and are related to medication effect, as well as nocturnal motor and non-motor symptoms [1, 2, 1, 2]. This includes but is not limited to tremor, painful dystonia, and nocturia leading to difficulty with sleep initiation and fragmentation of sleep [1, 2, 1, 2]. Reductions in total sleep time, stage N3 sleep and quality of life are common (Fig. 1) [2 –5]. Other sleep disorders in PD may include restless legs syndrome (RLS) and rapid eye movement behavior disorder (RBD) also negatively impact sleep and quality of life (Fig. 1) [2 –5].

Fig.1

Sleep disturbances in PD and the impact of DBS. This is representative of STN DBS given the relative paucity of data for GPi DBS.+++ = significant impact; ++ = moderate impact; + = mild impact; +/– = unknown or no impact.

Deep brain stimulation (DBS) is an established treatment for PD motor symptoms, but less is understood about the effect of DBS on sleep. More literature is emerging that describes changes in sleep after DBS using polysomnography (PSG) testing and various questionnaires. (Table 2). Here, we review the impact of DBS therapy on sleep architecture, nocturnal motor and non-motor PD symptoms, and sleep disorders in PD.

METHODS

We searched the literature using a combination of the following keywords: sleep, deep brain stimulation, Parkinson’s disease, subthalamic nucleus, globus pallidus, restless legs syndrome, rapid eye movement behavior disorder. Databases searched included PubMED/Medline and The Cochrane Library. For the purposes of this review, studies evaluating objective and subjective sleep disturbances and/or disorders in patients with PD who underwent DBS were included. The evaluation of sleep disturbances needed to include PSG or validated questionnaires. Case studies, clinical trials and reviews were all included given the relatively small amount of literature on this subject. The methodological approach for this review differs from other analyses as it includes nearly the entire literature on this topic. We included 72 peer-reviewed studies published from 1986 to late 2019 in this review.

RESULTS

Relationship of common PD DBS targets to sleep circuitry

Wakefulness and sleep are promoted by a number of distinct neuronal circuits and neurotransmitters that interact in a complex fashion to regulate the sleep-wake cycle. Wakefulness is promoted by a number of neurotransmitters that are released by a diffuse system throughout the brainstem, hypothalamus and basal forebrain (Fig. 2). Important structures and neurotransmitters involved in wakefulness include the locus coeruleus (norepinephrine), parabrachial nucleus/precoeruleus area (glutamate), raphe nucleus (serotonin), ventral periaqueductal gray matter (vlPAG; dopamine), tuberomammillary nucleus (histamine) and the pedunculopontine tegmental nuclei (PPN; acetylcholine) [6]. Sleep is modulated by circuits in the brain and brainstem that promote both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep [6]. NREM appears to be initiated by release of GABA by the ventrolateral preoptic area and median preoptic nuclei that inhibit the promotion of wakefulness system in the brainstem, thalamus and cerebral cortex [6]. The transition from NREM to REM occurs via a reciprocal switch in the brainstem. The lateral pontine tegmentum (LPT) and vlPAG inhibit the sublaterodorsal nucleus (SLD) and precoeruleus area (PA) during NREM. When REM is “turned on”, the SLD and PA reciprocally inhibit the LPT and vlPAG, as well as activate the basal forebrain [6]. This switch also allows for suppression of motor activity during REM sleep that originates from the SLD and PA and ultimately inhibiting spinal cord motor neurons via the nucleus magnocellularis (Fig. 2) [6]. Control of NREM to REM sleep transition and the descending control of muscle tone may be disrupted by alpha-synuclein protein deposition in these nuclei in PD, which is suspected to lead to loss of REM atonia or RBD [7, 8].

Fig.2

Areas of sleep-wake control and proposed connection to DBS targets: STN and GPi. A) Wakefulness is promoted by the excitatory interaction between orexin, locus coeruleus (LC), precoeruleus area (PA), raphe nucleus, ventral periaqueductal gray matter (vlPAG), tuberomammillary nucleus (TMN) and pedunculopontine tegmental nuclei (PPN). Sleep is induced by the ventrolateral preoptic area (VLPO) which inhibits the above nuclei. During REM, the sublateral dorsal nucleus (SLD), PA and PPN inhibit the lateral pontine tegmentum (LPT) and vlPAG. The SLD and PA also inhibit spinal cord motor neurons via the nucleus magnocellularis (NMC) to promote REM atonia. B) The STN receives excitatory cholinergic projections from the PPN and may act as a relay for information regarding wakefulness and REM sleep. The GPi sends inhibitory GABA projections to the PPN, likely reducing wakefulness and suppressing REM sleep.

The subthalamic nucleus (STN) is a common target for DBS in patients with PD. However, connectivity to the sleep-wake circuitry has not been well-established. Animal models demonstrate the PPN strongly modulates the neuronal activity of the STN via excitatory cholinergic projections, which may suggest a role of STN in processing information during REM sleep or wakefulness (Fig. 2B) [9 –11]. A recent study evaluated the microlesion effect of STN DBS lead placement with fMRI and demonstrated a general increase in activity throughout the brainstem, though specific nuclei were not identified [12, 13]. This suggests the STN heavily influences neuronal activity in the brainstem. Although a specific role for the subthalamic nucleus (STN) in sleep remains unclear, it appears to have significant connections with and influence on structures involved in the regulation of wakefulness and sleep.

Table 1

Summary of questionnaires used to evaluate daytime sleepiness and various measures of subjective sleep quality and nocturnal symptoms in Parkinson’s disease

Questionnaire	Range	Sleep issue evaluated
Pittsburgh Sleep Quality Index (PSQI) [23]	0–21	Seven-component questionnaire that assesses subjective measures of sleep and daytime dysfunction. Higher scores represent worse sleep. Scores of 5 or more indicate poor sleep quality
Epworth Sleepiness Scale (ESS) [25]	0–24	Eight-point questionnaire that assesses overall tendency to fall asleep during the day. Higher scores represent worse sleep. Scores greater than 10 represent excessive daytime sleepiness.
Insomnia Severity Index (ISI) [30]	0–28	Seven-point questionnaire that assesses severity of difficulty falling or maintaining sleep. Higher scores represent worse sleep. Scores of 10 or more identify insomnia.
Unified Parkinson’s Disease Rating Scale (UPDRS) [32]		Six section questionnaire that assesses the impact and severity of Parkinson’s disease in multiple domains including mood, activities of daily living, motor skills and complications of therapy. Part II and IV of this questionnaire evaluate general problems turning in bed and sleep disturbances, respectively.
Parkinson’s Disease Sleepiness Scale (PDSS) [35]	0–150	Fifteen-point questionnaire that assesses quality of sleep, as well as motor and non-motor symptoms of Parkinson’s disease that may disrupt sleep. Lower scores represent worse nocturnal symptoms.
Parkinson’s Disease Sleepiness Scale version 2 (PDSS-2) [36]	0–60	Fifteen-point questionnaire that assesses quality of sleep, as well as motor and non-motor symptoms of Parkinson’s disease that may disrupt sleep. Higher scores represent worse nocturnal symptoms.
NMS Questionnaire (NMSQuest) [45]	0–30	Thirty-point questionnaire which assesses non-motor symptoms of Parkinson’s disease, including sleep. Higher scores represent worse nocturnal symptoms.
International Restless Legs Syndrome Study Group Rating Scale (IRLSS) [63]	0–40	Ten-point questionnaire that assesses the severity of restless legs. Higher scores represent worse symptoms. Mild = 0–10, moderate = 11–20, severe = 21–30, very severe = 31–40.

Table 2

Summary of studies evaluating the impact of DBS on sleep issues in PD

Study	DBS site	Study size	Evaluation method	Follow-up	Effect of DBS
Arnulf et al. [18]	STN	10	PSG	3–6 months	Mean improvement in total sleep time by 47%, reduction in wakefulness after sleep onset by 51 min
Iranzo et al. [19]	STN	11	ESS, PSG, PSQI	6 months	No significant PSG changes, mean PSQI improvement by 63%
Monaca et al. [20]	STN	10	PSG, PSQI	3 months	Mean improvement in total sleep time by 28%, sleep efficiency by 40%, PSQI by 55%
Lyons et al. [21]	STN	11	ESS, UDPRS, time asleep	24 months	Slight increase in ESS, improvement of total sleep time by 1.3 hours
Bargiotas et al. [24]	STN	74	Actigraphy, ESS, PSG	12 months	Mean ESS improvement by ∼2, PSG not performed post-DBS
Baumann-Vogel et al. [26]	STN	50	Actigraphy, ESS, PSG	6 months	Mean improvement in total sleep time by 1 hour, reduction in ESS by 2.1 and increase of sleep efficiency by 5.2%
Amara et al. [27]	STN	57	PSG, PSQI	6 months	Mean PSQI improvement by 15% overall, however, only significant in right STN group
Tolleson et al. [29]	GPi	5	ESS, IRLSS, ISI, PDSS, PSG	6 months	Trend for improvement in all measures, but no significant changes
Odekerken et al. [31]	STN/GPi	118	PDSS, UPDRS	36 months	Mean PDSS improvement of 16% with STN, 8% with GPI
Follett et al. [32]	STN/GPi	299	UPDRS, time asleep	24 months	Improvement of total sleep time by 0.9 hours in GPi and 1 hour in STN group
Weaver et al. [33]	STN/GPi	121	UPDRS, time asleep	6 months	Improvement of total sleep time by 0.4 hours in both groups
Schuepbach et al. [34]	STN	251	UPDRS, time asleep	24 months	Improvement of total sleep time by 0.5 hours in DBS group
Chahine et al. [37]	STN	17	ESS, IRLSS, PDSS	6 months	Mean PDSS improvement by 33%, reduction of IRLSS by 9.2
Nishida et al. [38]	STN	10	PDSS, PSG	1–3 months	Mean PDSS improvement by 18%, reduction in wakefulness after sleep onset by 72 min, increase in REM time by 31 min (6%) and REM atonia by 30 min
Breen et al. [39]	STN	11	PDSS	6 months	Mean PDSS improvement by 18%
Kurcova et al. [40]	STN	24	PDSS, NMS Quest	4 months	Mean PDSS improvement by 9%
Choi et al. [41]	STN	46	PDSS	3 years	Mean PDSS improvement by 15%
Deli et al. [42]	STN	13	PDSS-2	12 months	Mean PDSS-2 improvement by 58%
Hjort et al. [43]	STN	10	PDSS-2	6 months	Mean PDSS improvement by 32%
Hidding et al. [44]	STN/SNr	15	PDSS-2		Mean restlessness and immobility scores lower in STN/SNr group
Rukmini Mridula et al. [46]	STN	56	NMSQuest	23 months	Sleep disturbances (25%) and nocturia (21%) less frequent in DBS group
Dafsari et al. [47]	STN	60	NMSQuest	6 months	Sleep (44%) and urinary disturbances (27%) less frequent in DBS group
Kim et al. [54]	STN	90	RBD diagnostic criteria	12 months	Onset of RBD in 18%
Kedia et al. [64]	STN	195	RLS criteria	4 months	New onset RLS after DBS at rate of 6%
Marques et al. [65]	STN	31	RLS criteria	6 months	New onset RLS after DBS at rate of 19%
Driver-Dunckley et al. [66]	STN	6	IRLS rating scale	3–24 months	Mean reduction of score by 20.8
Klepitskaya et al. [67]	STN	22	IRLS rating scale	24 months	Mean reduction of score by 7.8, 27% with complete resolution

The other common PD DBS target is the globus pallidus interna (GPi). This area receives dopaminergic projections from the midbrain and projects inhibitory GABA neurons to the PPN [11 , 14–16]. In a study of sleep-wake behavior in rats, GPi lesioning led to a 45.5% increase in wakefulness [14]. Furthermore, GPi DBS in monkey primates restored inhibitory activity over the PPN, an important nucleus in the promotion of wakefulness and REM sleep [15]. Although its specific role still remains unclear, GPi appears to promote sleep via inhibition of the PPN when activated by dopamine neurons (Fig. 2B) [16].

Impact of DBS on overall sleep in PD

Though sleep disturbances have significant impact on quality of life in PD patients, careful study of the effect of DBS on sleep has only recently been evaluated in more detail. Early studies included no greater than twelve patients, with most demonstrating subjective improvements and benefit in total sleep time, sleep efficiency, continuous sleep time, and reduced wakefulness after sleep onset (WASO) up to two years post implantation (Table 2) [17 –21]. Multiple studies have now evaluated the impact of both unilateral and bilateral STN DBS on objective and subjective sleep measures. The majority of these studies have used validated surveys to evaluate changes in sleep following STN DBS placement. One study evaluated the sleep quality of 53 patients prior to and following unilateral STN DBS placement with the Pittsburgh Sleep Quality Index (PSQI) [22]. This patient rated questionnaire measures sleep latency and overall sleep quality on a scale of 0–21 (Table 1) [23]. Higher scores represent worse sleep, while scores of 5 or more represent poor sleep quality. Significant improvement of the global PSQI was noted at six months in all patients (9.3±0.6 to 7.9±0.6, p = 0.013) [22]. When stratified by laterality, however, this improvement only remained significant in patients with right STN DBS therapy (n = 28) who had a higher baseline PSQI score than those with left STN DBS therapy (n = 25; right STN baseline 10.3±3.8 to 7.8±3.5 at six months post-op; left STN baseline 8.3±3.7 to 7.9±3.9 at six months post-op) [22]. Bargiotas et al. reviewed 74 cases of patients with PD who underwent STN DBS and were surveyed with the Epworth Sleepiness Scale (ESS) [24]. The ESS has a total score ranging from 0–24 and scores greater than 10 representing excessive daytime sleepiness [25]. This study noted a significant improvement in the ESS one year following DBS, though the mean ESS scores at baseline and after intervention were not listed in the study [24].

The largest prospective study to date evaluating the impact of STN DBS on sleep with PSG included 50 patients with PD [26]. This study also included assessment with the ESS before and six months after DBS placement, as well as two-week actigraphy. Significant improvements were noted in the ESS score in this study after DBS (9.4±4.6 to 7.4±3.9). Sleep efficiency (%; 73.6±16.0 to 78.9±16.1), total sleep time (min; 275.4±68.1 to 296.6±71.0) and total slow wave sleep (min; 42.6±34.9 to 53.8±43.3) also significantly improved on PSG findings [26]. This corroborated previous smaller studies that STN DBS placement improves both objective and subjective sleep measures.

Interestingly, one study evaluated different DBS stimulation frequencies and the impact on objective sleep measures [27]. Twenty PD patients with STN DBS were blindly randomized to three nights of PSG evaluation with one night at high frequency (≥130 Hz), one night at low frequency (60 Hz) and one night with DBS turned off. Settings were adjusted at 8pm on the night of each PSG, with at least three nights between PSGs. No significant differences were noted in objective sleep measures, including sleep efficiency (%; 77.8±17.3 vs. 71.6±22.5 vs. 77.0±15.8) and total sleep time (min; 357.9±98.7 vs. 321.9±123.4 vs. 349.1±73.6). As patients were evaluated for only one night on each setting, the lack of change in sleep measures may be related to a delay in treatment effect. Future study of other stimulation settings may be of interest.

GPi DBS may also have an impact on overall sleep quality, though only one prospective study with five patients has evaluated this with the use of PSG [28, 29]. Increases in stage N2 and REM sleep were noted on PSG after DBS. There were also trends toward improvement in sleep latency (min; 60±76.2 to 28.4±39.1), sleep efficiency (%; 59.2±32.3 to 72.6±14.6) and periodic limb movement index (events per hour; 32±39.1 to 6.8±9.8) for the pooled data [29]. None of these changes were statistically significant, however. This study also included the ESS and Insomnia Severity Index (ISI). The ISI ranges from 0–28 and identifies insomnia with a score greater than 10 [30]. A high score on this survey represents worse sleep (Table 1). The ESS did not significantly change (10.6±4.5 vs. 11.0±4.7; p = 0.85), while the ISI trended towards improvement (14.4±7.0 vs. 9.0±2.6; p = 0.07). The study size was likely too small to draw conclusions, though these positive trends are interesting.

Direct comparisons of DBS target on overall sleep effect are very limited. There has been only one study that evaluated the impact of DBS on sleep where patients (n = 90) were randomized to DBS target (STN or GPi) [31]. This study used the Parkinson’s Disease Sleep Scale (PDSS) to identify the presence and severity of nocturnal symptoms that can occur in PD (Table 1). This tool has fifteen domains with an overall score that ranges from 0–150. A lower score represents worse sleep, though clinically relevant values for this survey are not yet established. An improvement in mean overall PDSS scores of 12.1 was seen in the GPi group (n = 47) three years after DBS, while a mean overall improvement of 15.4 was seen in the STN group [31]. Analysis of each individual domain (tremor, akinesia, nocturia, etc.) was not performed, however, limiting assessment of these results.

Impact of DBS on nocturnal motor and non-motor symptoms in PD

Several randomized clinical trials have shown STN or GPi DBS is superior to best medical therapy for motor complications in PD [32 –34]. These studies largely focused on evaluating changes in motor symptoms based on the United Parkinson’s Disease Rating Scale Part III (UPDRS-III), while the patient is awake. A subjective evaluation of time spent asleep was measured by patient motor diaries in each trial. Total sleep time increased by nearly an hour in the three trials (range 0.4–0.9 hours) and trended towards significance, though recall bias may limit this result [32 –34]. Nocturnal symptoms of PD were not specifically assessed in these studies, however, all studies evaluated UPDRS Part II and IV, which include an assessment of the patient’s ability to turn in bed and adjust clothes, as well as any sleep disturbance. While individual assessments of these specific questions were not performed, a trend for improvement in overall scores for UPDRS part II and IV was found in each of the DBS groups in each trial [32 –34].

Development and utilization of newer sleep scales including two versions of the Parkinson’s Disease Sleep Scale (PDSS and PDSS-2) has helped to tease out specific improvement of nocturnal symptoms that may occur in PD (Table 1) [35, 36]. These 15-point questionnaires focus on subjective sleep measures, as well as nocturnal motor and non-motor features of PD, to provide an overall score for the impact of these features on sleep. Individual questions include motor features of tremor, immobility in bed and dystonia, as well as non-motor features such as nocturia, hallucinations and paresthesias. Clinically relevant thresholds have not yet been developed for these surveys.

Parkinson’s Disease Sleep Scale and Parkinson’s Disease Sleep Scale-2 outcomes

A number of studies have used the PDSS to evaluate changes in sleep quality following STN DBS for PD. This survey is scored from 0–150 with a lower score indicating worse nocturnal symptoms [35]. One early study (n = 17) demonstrated a statistically significant improvement in overall PDSS scores following DBS at six months (94.2 to 122.9; p < 0.001) [37]. Individual questions regarding motor and non-motor symptoms were not assessed specifically by this study. A similar study of ten patients also found that overall PDSS scores significantly improved at a mean follow-up of 68.8 days (96.0±18.4 to 115.3±16.5; p = 0.01) [38]. There was no significant improvement in individual motor and non-motor questions, but a trend for improvement in the motor subset of questions was seen. [38]. Breen et al. evaluated 11 patients and found a trend for improvement in nocturnal restlessness (6.06 to 7.49; p = 0.206) and nocturia (5.69 to 6.91.4; p = 0.13) at six months follow-up compared to baseline values, though none of these were statistically significant [39]. A similar study of 24 patients showed that overall PDSS scores significantly improved four months after DBS (111.2±21.3 to 121.7±23.4; p < 0.05) [40]. The largest study with longest follow-up to date evaluated 46 patients up to three years after DBS, demonstrating significant and sustained improvement in overall PDSS scores compared to baseline (79.0±30.0 to 93.3±28.0; p < 0.006) [41]. The nocturnal motor symptoms subset improved from 23.0±9.5 to 29.2±8.9 (p < 0.001), while no other subsets demonstrated significant improvement [41].

Only one study has used the PDSS to evaluate sleep changes following GPi DBS [29]. Five patients were evaluated with the PDSS six months after DBS, showing an overall improvement from 90.2±20.4 to 106.4±17.4. Individual subsets were not analyzed and overall change was not statistically significant.

The PDSS-2 was revised to include more specific questions regarding restlessness, tremor, cramping and other motor symptoms [36]. The range was also changed to 0–60, where a higher score indicates worse nocturnal symptoms. One study evaluated 25 PD patients with bilateral STN DBS one year after implantation [42]. Although a statistically significant improvement was seen in the total PDSS-2 score (24.8±9.9 to 14.2±11.4; p < 0.01), only a subset of questions showed significant improvement (tremor, akinesia, restlessness, cramps; p < 0.05). Improvements in non-motor symptoms including nocturia and daytime fatigue were not significant [42]. Similar results were found in an earlier study of ten patients at three months post-implantation, where non-motor symptoms did not appear to improve significantly [43]. A recent double-blind, cross-over study used the PDSS-2 to evaluate 15 patients with STN stimulation alone versus simultaneous STN and substantia nigra pars reticulata stimulation (SNr). The overall PDSS-2 scores were not significantly different between the STN and STN-SNr groups after stimulation. The STN-SNr significantly improved restlessness at night (1.0±1.8; p = 0.039) compared to STN alone (1.9±2.7), as well as akinesia (0.6±0.8 vs. 1.5±1.4; p = 0.041) highlighting the possible impact SNr stimulation may have on sleep in PD [44].

NMS Questionnaire outcomes

A handful of studies have specifically evaluated the frequency of non-motor symptoms in PD following STN DBS using the NMS Questionnaire (NMS Quest), a 30-item comprehensive questionnaire which assesses gastrointestinal, urinary, cardiovascular, sexual, cognition, mood, hallucinations/delusions and sleep dysfunction (Table 1) [45]. Though this questionnaire is not specifically geared towards only sleep, many of the symptoms evaluated occur at night and have been shown to disrupt sleep. The scale ranges from 0–30 and a higher score represents worse nocturnal symptoms. Clinically relevant thresholds have not yet been developed for this survey.

One recent study with 116 patients demonstrated a significantly lower mean NMS Quest score in DBS patients (6.7±3.8 vs. 8.4±3.7, p = 0.02) than controls at a mean follow-up of 1.9 years [46]. The DBS group also had significantly less overall percentage of sleep (44.6% vs. 69.8; p = 0.01) and urinary complaints (62.5% vs. 83.0%; p = 0.02) compared to controls [46]. Kurcova et al. evaluated 24 patients and found a significant improvement in NMS scores four months after DBS (37.2±22 to 26.6±23.7; p < 0.001) [37]. Although a significant difference in the sleep subsection was seen at one month (baseline 11.5±10.1 to 4.9±6.6; p = 0.001), this was not sustained at four months after DBS (11.5±10.1 to 6.3±7.6; p = 0.123) [40]. The most conclusive data to date is from a multi-center study of 67 patients treated with STN DBS showing a significant improvement in overall NMS Quest scores at 24 months (63.2±34.3 to 50.4±31.3; p = 0.001) [47]. Significant improvements in the urinary, hallucinations and sleep domains were also noted (p < 0.05) [47]. An analysis of stimulation location in this same group suggested that more ventral stimulation with DBS may be beneficial for sleep, possibly due to spread of current to the PPN area in the brainstem [48].

Despite the heterogeneity in surveys used to measure changes in sleep quality in patients with PD, there is now reasonable evidence to support the conclusion that DBS improves overall subjective quality of sleep, motor, and some non-motor symptoms of PD to varying degrees. Though these surveys rely on recall by either the patient or caretaker, which may introduce bias and confound the results, STN DBS appears to mediate sleep improvement through tremor and dystonia control throughout the night. The impact of STN DBS on nocturnal non-motor features of PD remains less clear and require further investigation.

Impact of DBS on RBD in PD

Rapid Eye Movement Behavior Disorder is a parasomnia that arises out of REM sleep and can present with an array of clinical symptoms ranging from vocalizations to violent motor behaviors in the setting of elevated tonic or phasic electromyographic chin or arm tone during REM sleep, known as loss of REM atonia [49]. RBD is a sleep disorder most commonly associated with alpha-synucleinopathies including PD, multiple system atrophy and Lewy body dementia. This disorder can lead to both self-injury and injury of bed partners. Long-term studies of “idiopathic” RBD have demonstrated that 91–96.6% of patients develop a neurodegenerative disorder 14 years after diagnosis [50, 51]. The majority of these cases were alpha-synucleinopathies such as PD or Lewy body dementia [50, 51].

Little research is available regarding the impact of DBS on RBD, and only data on STN is currently available. One study evaluated REM sleep changes in ten patients with PD before and after DBS [38]. The amount of REM sleep and atonic REM increased on PSG in four patients with loss of REM atonia prior to DBS, suggesting that STN DBS may help to reduce RBD [35]. However, the percent of REM atonia relative to REM sleep was not evaluated in this study, limiting the applicability of this result. The most comprehensive study to date retrospectively evaluated 90 patients [54]. Forty-seven patients had RBD at baseline, with resolution of RBD in only one patient and development of RBD in 16 patients after one year of DBS [54]. The authors concluded that the incidence of RBD increased after DBS. However, the total equivalent doses of levodopa and dopamine agonists significantly decreased in the RBD group. As these medications have been suggested as possible treatments for RBD in PD, this reduction of medications may have simply unmasked RBD that was treated with dopamine [54, 55]. Disease progression may also have played a role in the development of RBD. It is unclear if STN DBS therapy affects RBD, though further research is needed. To our knowledge, no studies have evaluated the interaction between GPi DBS and RBD.

Impact of DBS on RLS in PD

Restless Leg Syndrome (RLS) is defined as the urge to move one’s extremities, often due to discomfort [56]. These sensations arise during periods of rest, often when attempting to fall asleep, and are usually relieved by movement [56]. This syndrome can significantly affect sleep latency, sleep efficiency and sleep quality, as well as cause a notable decrease in quality of life. Prevalence of RLS in PD has been estimated to range from 8% to 24%, similar to that seen in the North American population (range 4% to 29%) [57 –62]. A state of dopamine depletion in PD may be a potential etiologic factor for RLS, however, the underlying causative factors are poorly understood [57 –60].

There has been conflicting evidence whether STN DBS helps to reduce RLS symptoms in patients with PD. Studies evaluating RLS have used both the RLS diagnostic criteria and International Restless Legs Syndrome Study Group rating scale (IRLS rating scale) [56, 63]. The IRLS rating scale assesses the severity of restless legs where 0–10 is mild, 11–20 is moderate, 21–30 is severe and 31–40 is very severe (Table 1). An early retrospective study evaluated 195 PD patients for RLS after treatment with STN DBS [64]. Only two patients reported mild RLS symptoms prior to DBS and suffered significant worsening of RLS symptoms, while nine patients reported new onset of RLS within 16 weeks of DBS implantation (mean IRLS rating scale 15.0±5.9). This followed a reduction in mean levodopa equivalent daily doses (LEDD) of 79%, suggesting that emergence of RLS may have been confounded by withdrawal of medications that are known treatments for this disorder. Those who did not have RLS after surgery only had a mean LEDD reduction of 40.4% suggesting dopamine medications were still high enough to treat RLS symptoms [64]. A clear study limitation was that patients were not screened for RLS at baseline. A more recent prospective study evaluated 31 patients with PD treated with STN DBS for occurrence of RLS following implantation [65]. No patients had RLS at baseline and six patients developed RLS symptoms up to 6 months following DBS surgery (median IRLS rating scale 16[14;19]). These patients were on a higher LEDD than those without RLS symptoms post-operatively, again suggesting either DBS unmasked RLS symptoms or the development of RLS was a side effect of dopamine medications, known as augmentation [65].

In contrast, a smaller prospective study of six patients with PD and RLS used the IRLS rating scale to evaluate severity of symptoms before and after STN DBS [66]. After STN DBS, there was a decrease in mean IRLS rating scale from 24.8±8.3 to 4.0±5.8. This was despite a 56% decrease in mean LEDD, suggesting that STN DBS can help reduce RLS symptoms [66]. These findings were confirmed by Chahine et al who studied 17 PD patients before and after STN DBS [37]. Six patients had RLS prior to STN DBS implantation with a mean IRLS rating scale of 23.0 at baseline. These scores significantly decreased to 14.8 at four weeks and 13.8 at six months post-implantation [37]. More recently, a prospective trial of 22 patients with PD undergoing STN DBS demonstrated that mean IRLS rating scale significantly improved from 19.6 to 11.8 two years post-implantation, despite a reduction in LEDD [67]. Twenty seven percent of patients experienced complete resolution, while 11 patients experienced at least 50% improvement. No correlation was found between RLS improvement and reduction in PD medications, suggesting that STN DBS may have mediated this improvement [67]. Though the results of these studies are likely influenced by medication adjustments, the most recent evidence appears to suggest that STN DBS may help with RLS symptoms in the long-term.

One study has evaluated the impact of GPi DBS on RLS in five patients with PD (29). The IRLS rating scale improved from 9.8±14.0 to 3.4±4.7, but this was not statistically significant most likely due to study size. Other reports of the effect of GPi DBS on RLS are in non-PD patients. A case report of a patient with generalized dystonia found that RLS symptoms resolved after bilateral GPi DBS [68]. One other study found that GPi DBS implanted specifically for severe isolated RLS did not appear to significantly improve symptoms [69]. Further research is needed in this area.

CONCLUSION

Parkinson’s disease has a negative impact on sleep via presence of motor and non-motor symptoms that disrupt normal sleep architecture. Various sleep disorders associated with PD also negatively impact quality of sleep. While STN and GPi DBS are proven therapies for treatment of motor complications from PD, the impact on sleep has only recently been explored. Both the STN and GPi have been shown to influence the interaction between wakefulness and sleep, with likely more impact on REM sleep in particular. DBS at both sites improves objective and subjective sleep measures in patients with PD, though there is considerably more data on STN DBS. Notably, nocturnal motor symptoms appear to significantly improve with DBS therapy. Non-motor symptoms, such as nocturia, do not appear to respond as well to DBS. Given the paucity of data, the impact of STN DBS on RBD is unclear and requires further investigation. Recent data have suggested that improvements in RLS may be mediated by STN DBS itself, despite mixed results in earlier studies. Literature regarding GPi DBS is also limited overall.

Despite the findings from studies of DBS in PD, it is difficult to separate the effect of medication adjustments from the impact of DBS as it relates to sleep issues. After DBS implantation, equivalent dopamine dosages are typically reduced. L-dopa and dopamine agonists appear to impact sleep by reducing wake after sleep onset and improving sleep efficiency, likely through treatment of nocturnal symptoms of PD [70, 71]. This may suggest DBS mediates improvement either as a direct influence on sleep circuitry or by improving PD symptoms as medications are lowered. Dopamine medications can also effectively treat RLS symptoms or create augmentation of them, with earlier onset and/or spread of symptoms from legs to other body parts. Because of this dual effect, the impact of medication adjustment on RLS symptoms following DBS is also difficult to assess. Given the complexities of interaction between the progression of PD, DBS and medications, further investigation is needed into the long-term impact of DBS on sleep architecture and sleep disorders in PD.

CONFLICT OF INTEREST

Dr. Zuzuárregui reports no disclosures. Dr. Ostrem has received grant support from the Michael J. Fox Foundation, Boston Scientific, Medtronic, Cala Health, DOD Defense Advanced Research Projects Agency, Biogen, Acadia, Allergan and AbbVie.

Footnotes

ACKNOWLEDGMENTS

This study was not funded.

References

Martinez-Martin

, Rodriguez-Blazquez

, Kurtis

, Chaudhuri

, NMSS Validation Group (2011) The impact of non-motor symptoms on health-related quality of life of patients with Parkinson’s disease. Mov Disord 26, 399–406.

Gómez-Esteban

, Tijero

, Somme

, Ciordia

, Berganzo

, Rouco

, Bustos

, Valle

, Lezcano

, Zarranz

(2011) Impact of psychiatric symptoms and sleep disorders on the quality of life of patients with Parkinson’s disease. J Neurol 258, 494–9.

Rolinski

, Szewczyk-Krolikowski

, Tomlinson

, Nithi

, Talbot

, Ben-Shlomo

, Hu

(2014) REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson’s disease. J Neurol Neurosurg Psychiatry 85, 560–566.

Rijsman

, Schoolderman

, Rundervoort

, Louter

(2014) Restless legs syndrome in Parkinson’s disease. Relat Disord 20, S5–S9.

Mantovani

, Smith

, Gordon

, O’Sullivan

(2018) An overview of sleep and circadian dysfunction in Parkinson’s disease. J Sleep Res 27, e12673.

Horner

, Peever

(2017) Brain circuitry controlling sleep and wakefulness. Continuum 23, 955–972.

Boeve

, Dickson

, Olson

, Shepard

, Silber

, Ferman

, Ahlskog

, Benarroch

(2007) Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Med 8, 60–64.

Postuma

, Adler

, Dugger

, Hentz

, Shill

, Driver-Dunckley

, Sabbagh

, Jacobson

, Belden

, Sue

, Serrano

, Beach

(2015) REM sleep behavior disorder and neuropathology in Parkinson’s disease. Mov Disord 30, 1413–1417.

Fernández-Mendoza

, Lozano

, Seijo

, Santamarta-Liébana

, Ramos-Platón

, Vela-Bueno

, Fernández-González

(2009) Evidence of subthalamic PGO-like waves during REM sleep in humans: A deep brain polysomnographic study. Sleep 32, 1117–1126.

10.

Bevan

, Bolam

(2009) Cholinergic, GABAergic, and glutamate-enriched inputs from the mesopontine tegmentum to the subthalamic nucleus in the rat. J Neurosci 15, 7105–7120.

11.

Kita

, Kita

(2011) Cholinergic and non-cholinergic mesopontine tegmental neurons projecting to the subthalamic nucleus in the rat. Eur J Neurosci 33, 433–443.

12.

Merlino

, Lettieri

, Mondani

, Belgrado

, Devigili

, Mucchiut

, Rinaldo

, Craighero

, D’Auria

, Skrap

, Eleopra

(2014) Microsubthalamotomy improves sleep in patients affected by advanced Parkinson’s disease. Med 15, 637–641.

13.

Holiga

, Mueller

, Möller

, Urgošík

, Růžička

, Schroeter

, Jech

(2015) Resting-state functional magnetic resonance imaging of the subthalamic microlesion and stimulation effects in Parkinson’s disease: Indications of a principal role of the brainstem. Neuroimage Clin 21, 264–274.

14.

Qiu

, Vetrivelan

, Fuller

, Lu

(2010) Basal ganglia control of sleep-wake behavior and cortical activation. Eur J Neurosci 31, 499–507.

15.

Zhang

, Wang

, Baker

, Vitek

(2012) Effect of globus pallidus internus stimulation on neuronal activity in the pedunculopontine tegmental nucleus in the primate model of Parkinson’s disease. Exp Neurol 233, 575–580.

16.

Qiu

, Yao

, Vetrivelan

, Chen

, Lu

(2016) Nigrostriatal Dopamine Acting on Globus Pallidus Regulates Sleep. Cereb Cortex 26, 1430–1439.

17.

Antonini

, Landi

, Mariani

, DeNotaris

, Pezzoli

(2004) Deep brain stimulation and its effect on sleep in Parkinson’s disease. Med 5, 211–214.

18.

Arnulf

, Bejjani

, Garma

, Bonnet

, Houeto

, Damier

, Derenne

, Agid

(2000) Improvement of sleep architecture in PD with subthalamic nucleus stimulation. Neurology 55, 1732–1734.

19.

Iranzo

, Valldeoriola

, Santamaría

, Tolosa

, Rumià

(2002) Sleep symptoms and polysomnographic architecture in advanced Parkinson’s disease after chronic bilateral subthalamic stimulation. J Neurol Neurosurg Psychiatry 72, 661–664.

20.

Monaca

, Ozsancak

, Jacquesson

, Poirot

, Blond

, Destee

, Guieu

, Derambure

(2004) Effects of bilateral subthalamic stimulation on sleep in Parkinson’s disease. J Neurol 251, 214–218.

21.

Lyons

, Pahwa

(2006) Effects of bilateral subthalamic nucleus stimulation on sleep, daytime sleepiness, and early morning dystonia in patients with Parkinson disease. J Neurosurg 104, 502–505.

22.

Amara

, Standaert

, Guthrie

, Cutter

, Watts

, Walker

(2012) Unilateral subthalamic nucleus deep brain stimulation improves sleep quality in Parkinson’s disease. Parkinsonism Relat Disord 18, 63–68.

23.

Buysse

, Reynolds CF

III

, Monk

, Berman

, Kupfer

(1989) The pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Res 28, 193–213.

24.

Bargiotas

, Eugster

, Oberholzer

, Debove

, Lachenmayer

, Mathis

, Pollo

, Schüpbach

WMM

, Bassetti

(2017) Sleep-wake functions and quality of life in patients with subthalamic deep brain stimulation for Parkinson’s disease. PLoS One 12, e0190027.

25.

Johns

(1991) A new method for measuring daytime sleepiness: The Epworth sleepiness scale. Sleep 14, 540–545.

26.

Baumann-Vogel

, Imbach

, Sürücü

, Stieglitz

, Waldvogel

, Baumann

, Werth

(2017) The impact of subthalamic deep brain stimulation on sleep-wake behavior: A prospective electrophysiological study in 50 Parkinson patients. Sleep 40, 5.

27.

Amara

, Walker

, Joop

, Cutter

, DeWolfe

, Harding

, Standaert

(2017) Effects of subthalamic nucleus deep brain stimulation on objective sleep outcomes in Parkinson’s disease. Mov Disord Clin Pract 4, 183–190.

28.

Eugster

, Bargiotas

, Bassetti

, Michael Schuepbach

(2016) Deep brain stimulation and sleep-wake functions in Parkinson’s disease: A systematic review. Parkinsonism Relat Disord 32, 12–19.

29.

Tolleson

, Bagai

, Walters

, Davis

(2016) A pilot study assessing the effects of pallidal deep brain stimulation on sleep quality and polysomnography in Parkinson’s patients. Neuromodulation 19, 724–730.

30.

Bastien

, Vallières

, Morin

(2001) Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med 2, 297–307.

31.

Odekerken

, Boel

, Schmand

, de Haan

, Figee

, van den Munckhof

, Schuurman

, de Bie

, NSTAPS study group (2016) GPi vs STN deep brain stimulation for Parkinson disease: Three-year follow-up. Neurology 86, 755–761.

32.

Follett

, Weaver

, Stern

, Hur

, Harris

, Luo

, Marks

Jr , Rothlind

, Sagher

, Moy

, Pahwa

, Burchiel

, Hogarth

, Lai

, Duda

, Holloway

, Samii

, Horn

, Bronstein

, Stoner

, Starr

, Simpson

, Baltuch

, De Salles

, Huang

, Reda

; CSP 468 Study Group (2010) Pallidal versus subthalamic deep-brain stimulation for Parkinson’s disease. N Engl J Med 362, 2077–2091.

33.

Weaver

, Follett

, Stern

, Hur

, Harris

, Marks

Jr , Rothlind

, Sagher

, Reda

, Moy

, Pahwa

, Burchiel

, Hogarth

, Lai

, Duda

, Holloway

, Samii

, Horn

, Bronstein

, Stoner

, Heemskerk

, Huang

; CSP 468 Study Group (2009) Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: A randomized controlled trial. JAMA 301, 63–73.

34.

Schuepbach

, Rau

, Knudsen

, Volkmann

, Krack

, Timmermann

, Hälbig

, Hesekamp

, Navarro

, Meier

, Falk

, Mehdorn

, Paschen

, Maarouf

, Barbe

, Fink

, Kupsch

, Gruber

, Schneider

, Seigneuret

, Kistner

, Chaynes

, Ory-Magne

, Brefel Courbon

, Vesper

, Schnitzler

, Wojtecki

, Houeto

, Bataille

, Maltête

, Damier

, Raoul

, Sixel-Doering

, Hellwig

, Gharabaghi

, Krüger

, Pinsker

, Amtage

, Régis

, Witjas

, Thobois

, Mertens

, Kloss

, Hartmann

, Oertel

, Post

, Speelman

, Agid

, Schade-Brittinger

, Deuschl

; EARLYSTIM Study Group (2013) Neurostimulation for Parkinson’s disease with early motor complications. N Engl J Med 368, 610–622.

35.

Chaudhuri

, Pal

, DiMarco

, Whately-Smith

, Bridgman

, Mathew

, Pezzela

, Forbes

, Högl

, Trenkwalder

(2002) The Parkinson’s disease sleep scale: A new instrument for assessing sleep and nocturnal disability in Parkinson’s disease. J Neurol Neurosurg Psychiatry 73, 629–635.

36.

Trenkwalder

, Kohnen

, Högl

, Metta

, Sixel-Döring

, Frauscher

, Hülsmann

, Martinez-Martin

, Chaudhuri

(2011) Parkinson’s disease sleep scale–validation of the revised version PDSS-2. Mov Disord 26, 644–652.

37.

Chahine

, Ahmed

, Sun

(2011) Effects of STN DBS for Parkinson’s disease on restless legs syndrome and other sleep-related measures. Parkinsonism Relat Disord 17, 208–211.

38.

Nishida

, Murakami

, Kadoh

, Tohge

, Yamanegi

, Saiki

, Ueda

, Matsumoto

, Ishikawa

, Takahashi

, Toda

(2011) Subthalamic nucleus deep brain stimulation restores normal rapid eye movement sleep in Parkinson’s disease. Mov Disord 26, 2418–2422.

39.

Breen

, Low

, Misbahuddin

(2015) The impact of deep brain stimulation on sleep and olfactory function in Parkinson’s disease. Open Neurol J 30, 70–72.

40.

Kurcova

, Bardon

, Vastik

, Vecerkova

, Frolova

, Hvizdosova

, Nevrly

, Mensikova

, Otruba

, Krahulik

, Kurca

, Sivak

, Zapletalova

, Kanovsky

(2018) Bilateral subthalamic deep brain stimulation initial impact on nonmotor and motor symptoms in Parkinson’s disease: An open prospective single institution study. Medicine 97, e9750.

41.

Choi

, Kim

, Lee

, Yoo

, Im

, Paek

, Jeon

(2019) Long-term effects of bilateral subthalamic nucleus stimulation on sleep in patients with Parkinson’s disease. PLoS One 14, e0221219.

42.

Deli

, Aschermann

, Ács

, Bosnyák

, Janszky

, Faludi

, Makkos

, Kovács

, Komoly

, Balás

, Dóczi

, Kovács

(2015) Bilateral subthalamic stimulation can improve sleep quality in Parkinson’s disease. J Parkinsons Dis 5, 361–368.

43.

Hjort

, Ostergaard

, Dupont

(2004) Improvement of sleep quality in patients with advanced Parkinson’s disease treated with deep brain stimulation of the subthalamic nucleus. Mov Disord 19, 196–199.

44.

Hidding

, Gulberti

, Pflug

, Choe

, Horn

, Prilop

, Braaß

, Fründt

, Buhmann

, Weiss

, Westphal

, Engel

, Gerloff

, Köppen

, Hamel

, Moll

CKE

, Pötter-Nerger

(2019) Modulation of specific components of sleep disturbances by simultaneous subthalamic and nigral stimulation in Parkinson’s disease. Parkinsonism Relat Disord 62, 141–147.

45.

Chaudhuri

, Martinez-Martin

, Schapira

, Stocchi

, Sethi

, Odin

, Brown

, Koller

, Barone

, MacPhee

, Kelly

, Rabey

, MacMahon

, Thomas

, Ondo

, Rye

, Forbes

, Tluk

, Dhawan

, Bowron

, Williams

, Olanow

(2006) International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson’s disease: The NMSQuest study. Mov Disord 21, 916–923.

46.

Rukmini Mridula

, Borgohain

, Jabeen

, Padmaja

, Bandaru

, Ankathi

, Kanikannan

, Ali Khan

(2015) Comparison of frequencies of non motor symptoms in Indian Parkinson’s disease patients on medical management versus deep brain stimulation: A case-control study. Iran J Neurol 14, 86–93.

47.

Dafsari

, Silverdale

, Strack

, Rizos

, Ashkan

, Mahlstedt

, Sachse

, Steffen

, Dembek

, Visser-Vandewalle

, Evans

, Antonini

, Martinez-Martin

, Ray-Chaudhuri

, Timmermann

; EUROPAR and the IPMDS Non Motor PD Study Group (2018) Nonmotor symptoms evolution during 24 months of bilateral subthalamic stimulation in Parkinson’s disease. Mov Disord 33, 421–430.

48.

Dafsari

, Petry-Schmelzer

, Ray-Chaudhuri

, Ashkan

, Weis

, Dembek

, Samuel

, Rizos

, Silverdale

, Barbe

, Fink

, Evans

, Martinez-Martin

, Antonini

, Visser-Vandewalle

, Timmermann

; EUROPAR; IPMDS Non Motor PD Study Group (2018) Non-motor outcomes of subthalamic stimulation in Parkinson’s disease depend on location of active contacts. Brain Stimul 11, 904–912.

49.

Arnaldi

, Antelmi

, St Louis

, Postuma

, Arnulf

(2017) Idiopathic REM sleep behavior disorder and neurodegenerative risk: To tell or not to tell to the patient? How to minimize the risk? Med Rev 36, 82–95.

50.

Iranzo

, Fernández-Arcos

, Tolosa

, Serradell

, Molinuevo

, Valldeoriola

, Gelpi

, Vilaseca

, Sánchez-Valle

, Lladó

, Gaig

, Santamaría

(2014) Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: Study in 174 patients. PLoS One 9, e89741.

51.

Galbiati

, Verga

, Giora

, Zucconi

, Ferini-Strambi

(2019) The risk of neurodegeneration in REM sleep behavior disorder: A systematic review and meta-analysis of longitudinal studies. Sleep Med Rev 34, 37–46.

52.

Zibetti

, Rizzi

, Colloca

, Cinquepalmi

, Angrisano

, Castelli

, Lanotte

, Lopiano

(2010) Probable REM sleep behaviour disorder and STN-DBS outcome in Parkinson’s disease. Parkinsonism Relat Disord 16, 265–269.

53.

Bargiotas

, Debove

, Bargiotas

, Lachenmayer

, Ntafouli

, Vayatis

, Schüpbach

, Krack

, Bassetti

(2019) Effects of bilateral stimulation of the subthalamic nucleus in Parkinson’s disease with and without REM sleep behaviour disorder. J Neurol Neurosurg Psychiatry 90, 1310–1316.

54.

Kim

, Jeon

, Paek

, Yun

, Yang

, Kim

, Ehm

, Kim

, Lee

, Kim

(2015) Rapid eye movement sleep behavior disorder after bilateral subthalamic stimulation in Parkinson’s disease. J Clin Neurosci 22, 315–319.

55.

Aurora

, Zak

, Maganti

, Auerbach

, Casey

, Chowdhuri

, Karippot

, Ramar

, Kristo

, Morgenthaler

; Standards of Practice Committee; American Academy of Sleep Medicine (2010) Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med 6, 85–95.

56.

Allen

, Picchietti

, Garcia-Borreguero

, Ondo

, Walters

, Winkelman

, Zucconi

, Ferri

, Trenkwalder

, Lee

; International Restless Legs Syndrome Study Group (2014) Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: Updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria—history, rationale, description, and significance. Sleep Med 15, 860–873.

57.

Innes

, Selfe

, Agarwal

(2011) Prevalence of restless legs syndrome in North American and Western European populations: A systematic review. Sleep Med 12, 623–634.

58.

Koo

(2015) Restless leg syndrome across the globe: Epidemiology of the restless legs syndrome/Willis-Ekbom disease. Sleep Med Clin 10, 189–205.

59.

Trenkwalder

, Allen

, Högl

, Paulus

, Winkelmann

(2016) Restless legs syndrome associated with major diseases: A systematic review and new concept. Neurology 86, 1336–1343.

60.

Peralta

, Frauscher

, Seppi

, Wolf

, Wenning

, Högl

, Poewe

(2009) Restless legs syndrome in Parkinson’s disease. Mov Disord 24, 2076–2080.

61.

Iranzo

, Comella

, Santamaria

, Oertel

(2007) Restless legs syndrome in Parkinson’s disease and other neurodegenerative diseases of the central nervous system. Mov Disord 22, S424–S430.

62.

Bhalsing

, Suresh

, Muthane

, Pal

(2013) Prevalence and profile of Restless Legs Syndrome in Parkinson’s disease and other neurodegenerative disorders: A case-control study. Relat Disord 19, 426–430.

63.

Walters

, LeBrocq

, Dhar

, Hening

, Rosen

, Allen

, Trenkwalder

; International Restless Legs Syndrome Study Group (2003) Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 4, 121–132.

64.

Kedia

, Moro

, Tagliati

, Lang

, Kumar

(2004) Emergence of restless legs syndrome during subthalamic stimulation for Parkinson disease. Neurology 63, 2410–2412.

65.

Marques

, Fantini

, Morand

, Pereira

, Derost

, Ulla

, Debilly

, Lemaire

, Durif

(2015) Emergence of restless legs syndrome after subthalamic stimulation in Parkinson’s disease: A dopaminergic overstimulation? Sleep Med 16, 583–588.

66.

Driver-Dunckley

, Evidente

, Adler

, Hillman

, Hernandez

, Fletcher

, Lyons

(2006) Restless legs syndrome in Parkinson’s disease patients may improve with subthalamic stimulation. Mov Disord 21, 1287–1289.

67.

Klepitskaya

, Liu

, Sharma

, Sillau

, Tsai

, Walters

(2018) Deep brain stimulation improves restless legs syndrome in patients with Parkinson disease. Neurology 91, e1013–e1021.

68.

Okun

, Fernandez

, Foote

(2005) Deep brain stimulation of the GPi treats restless legs syndrome associated with dystonia. Mov Disord 20, 500–501.

69.

Ondo

, Jankovic

, Simpson

, Jimenez-Shahed

(2012) Globus pallidus deep brain stimulation for refractory idiopathic restless legs syndrome. Sleep Med 13, 1202–1204.

70.

Ferreira

, Prabhakar

, Kharbanda

(2014) Sleep disturbances in drug naïve Parkinson’s disease (PD) patients and effect of levodopa on sleep. Ann Indian Acad Neurol 17, 416–419.

71.

Pierantozzi

, Placidi

, Liguori

, Albanese

, Imbriani

, Marciani

, Mercuri

, Stanzione

, Stefani

(2016) Rotigotine may improve sleep architecture in Parkinson’s disease: A double-blind, randomized, placebo-controlled polysomnographic study. Sleep Med 21, 140–144.