This paper theoretically analyzed the influence of symbiosis intimacy, cultural coupling, betrayal cost, degree of lock-in, geographic distance, and economic development on the stability of the coupling symbiosis network of industry-university-research (IUR), and conducted empirical analysis. The study found that symbiosis intimacy, cultural coupling, betrayal cost, degree of lock-in, and economic development all play a role in promoting the stability of the coupling symbiosis network of IUR, while geographical location is related to the stability of the coupling symbiosis network of IUR, but does not have a direct impact. Based on the empirical analysis results, the countermeasures and suggestions to improve the stability of coupling symbiosis network of the IUR were proposed.
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