Restricted accessResearch articleFirst published online 2017-6-23
Exploring Potential Electrophysiological Biomarkers in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis of Event-Related Potential Studies
Background: Early diagnosis and effective management are pivotal steps in preventing the transition from mild cognitive impairment (MCI) to Alzheimer’s disease. Previous investigations indicated that some event-related potential (ERP) components in MCI are sensitive to cognitive decline. However, several comparative analyses of these components in MCI and healthy controls (HC) yielded inconsistent results.
Objective: The aim was to perform a systematic review and meta-analysis of ERP studies on MCI patients.
Methods: We systematically searched on PubMed and Web of Science for MCI-related ERP studies published from April 1986 to August 2016. Standard mean difference estimates of all components were compared between MCI and HC.
Results: Our study showed increased P50 amplitude at the Cz site; reduced N2pc amplitude and delayed P200 latency at the Cz site; N200 latency at the Cz and Pz sites, and P300 latency at the Cz and Pz sites in MCI patients compared to HC.
Conclusions: In summary, our study indicated that some ERP components, such as P50 and N2pc amplitude, P200, N200, and P300 latency might be potential electrophysiological biomarkers for MCI diagnosis.
GrundmanM, PetersenRC, FerrisSH, ThomasRG, AisenPS, BennettDA, FosterNL, JackCRJr, GalaskoDR, DoodyR (2004) Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. JAMA Neurol61, 59–66.
2.
BischkopfJ, BusseA, AngermeyerMC (2002) Mild cognitive impairment— A review of prevalence, incidence and outcome according to current approaches. Acta Psychiatr Scand106, 403–414.
3.
NunezPL, SrinivasanR (2006) Electric fields of the brain: The neurohysics of EEG, Oxford University Press.
4.
CesponJ, Galdo-AlvarezS, PereiroAX, DiazF (2015) Differences between mild cognitive impairment subtypes as indicated by event-related potential correlates of cognitive and motor processes in a Simon task. J Alzheimers Dis43, 631–647.
5.
Ramos-GoicoaM, Galdo-AlvarezS, DiazF, ZurronM (2016) Effect of normal aging and of mild cognitive impairment on event-related potentials to a Stroop Color-Word Task. J Alzheimers Dis52, 1487–1501.
6.
JiangS, QuC, WangF, LiuY, QiaoZ, QiuX, YangX, YangY (2015) Using event-related potential P300 as an electrophysiological marker for differential diagnosis and to predict the progression of mild cognitive impairment: A meta-analysis. Neurol Sci36, 1105–1112.
7.
CesponJ, Galdo-AlvarezS, DiazF (2015) Inhibition deficit in the spatial tendency of the response in multiple-domain amnestic mild cognitive impairment. An event-related potential study. Front Aging Neurosci7, 68.
8.
YamasakiT, HorieS, OhyagiY, TanakaE, NakamuraN, GotoY, KanbaS, KiraJ, TobimatsuS (2016) A potential VEP biomarker for mild cognitive impairment: Evidence from selective visual deficit of higher-level dorsal pathway. J Alzheimers Dis53, 661–676.
9.
OlichneyJM, YangJC, TaylorJ, KutasM (2011) Cognitive event-related potentials: Biomarkers of synaptic dysfunction across the stages of Alzheimer’s disease. J Alzheimers Dis26(Suppl 3), 215–228.
10.
GolobEJ, JohnsonJK, StarrA (2002) Auditory event-related potentials during target detection are abnormal in mild cognitive impairment. Clin Neurophysiol113, 151–161.
11.
ListerJJ, Harrison BushAL, AndelR, MatthewsC, MorganD, EdwardsJD (2016) Cortical auditory evoked responses of older adults with and without probable mild cognitive impairment. Clin Neurophysiol127, 1279–1287.
12.
PapaliagkasV, KimiskidisV, TsolakiM, AnogianakisG (2008) Usefulness of event-related potentials in the assessment of mild cognitive impairment. BMC Neurosci9, 107.
13.
CesponJ, Galdo-AlvarezS, DiazF (2013) Electrophysiological correlates of amnestic mild cognitive impairment in a simon task. PLoS One8, e81506.
14.
WangP, ZhangX, LiuY, LiuS, ZhouB, ZhangZ, YaoH, ZhangX, JiangT (2013) Perceptual and response interference in Alzheimer’s disease and mild cognitive impairment. Clin Neurophysiol124, 2389–2396.
15.
WaldoMC, FreedmanR (1986) Gating of auditory evoked responses in normal college students. Psychiatry Res19, 233–239.
16.
EarlsHA, CurranT, MittalV (2016) A meta-analytic review of auditory event-related potential components as endophenotypes for schizophrenia: Perspectives from first-degree relatives. Schizophr Bull42, 1504–1516.
17.
KarlA, MaltaLS, MaerckerA (2006) Meta-analytic review of event-related potential studies in post-traumatic stress disorder. Biol Psychol71, 123–147.
18.
ArciniegasDB, TopkoffJL (2004) Applications of the P50 evoked response to the evaluation of cognitive impairments after traumatic brain injury. Phys Med Rehabil Clin N Am15, 177–203, viii.
19.
LiuJ, HarrisA, KanwisherN (2002) Stages of processing in face perception: An MEG study. Nat Neurosci5, 910–916.
20.
WolpawJR, PenryJK (1975) A temporal component of the auditory evoked response. Electroencephalogr Clin Neurophysiol39, 609–620.
21.
CrowleyKE, ColrainIM (2004) A review of the evidence for P2 being an independent component process: Age, sleep and modality. Clin Neurophysiol115, 732–744.
22.
BennysK, PortetF, TouchonJ, RondouinG (2007) Diagnostic value of event-related evoked potentials N200 and P300 subcomponents in early diagnosis of Alzheimer’s disease and mild cognitive impairment. J Clin Neurophysiol24, 405–412.
23.
EimerM (1996) The N2pc component as an indicator of attentional selectivity. Electroencephalogr Clin Neurophysiol99, 225–234.
24.
PatelSH, AzzamPN (2005) Characterization of N200 and P300: Selected studies of the event-related potential. Int J Med Sci2, 147–154.
25.
PictonTW, AlainC, OttenL, RitterW, AchimA (2000) Mismatch negativity: Different water in the same river. Audiol Neurootol5, 111–139.
26.
PolichJ (2007) Updating P300: An integrative theory of P3a and P3b. Clin Neurophysiol118, 2128–2148.
27.
QuirozGY (2003) [N400: An electrophysiological measure of semantic processing.]. Rev Neurol36, 1176–1180.
28.
TaylorJR, OlichneyJM (2007) From amnesia to dementia: ERP studies of memory and language. Clin EEG Neurosci38, 8–17.
29.
SchefterM, WerheidK, AlmkvistO, Lonnqvist-AkenineU, KathmannN, WinbladB (2013) Recognition memory for emotional faces in amnestic mild cognitive impairment: An event-related potential study. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn20, 49–79.
30.
HoppstadterM, KingAV, FrolichL, WessaM, FlorH, MeyerP (2013) A combined electrophysiological and morphological examination of episodic memory decline in amnestic mild cognitive impairment. Front Aging Neurosci5, 51.
31.
FriedmanD, JohnsonR (2000) Event-related potential (ERP) studies of memory encoding and retrieval: A selective review. Microsc Res Tech51, 6–28.
32.
FriedmanD (2013) The cognitive aging of episodic memory: A view based on the event-related brain potential. Front Behav Neurosci7, 111.
33.
XuH, ZhangQ, LiB, GuoC (2015) Dissociable effects of valence and arousal on different subtypes of old/new effect: Evidence from event-related potentials. Front Hum Neurosci9, 650.
34.
LindinM, CorreaK, ZurronM, DiazF (2013) Mismatch negativity (MMN) amplitude as a biomarker of sensory memory deficit in amnestic mild cognitive impairment. Front Aging Neurosci5, 79.
35.
StothartG, KazaninaN, NaatanenR, HaworthJ, TalesA (2015) Early visual evoked potentials and mismatch negativity in Alzheimer’s disease and mild cognitive impairment. J Alzheimers Dis44, 397–408.
LiBY, TangHD, ChenSD (2016) Retrieval deficiency in brain activity of working memory in amnesic mild cognitive impairment patients: A brain event-related potentials study. Front Aging Neurosci8, 54.
38.
MissonnierP, DeiberMP, GoldG, HerrmannFR, MilletP, MichonA, Fazio-CostaL, IbanezV, GiannakopoulosP (2007) Working memory load-related electroencephalographic parameters can differentiate progressive from stable mild cognitive impairment. Neuroscience150, 346–356.
39.
PhillipsNA, ChertkowH, LeblancMM, PimH, MurthaS (2004) Functional and anatomical memory indices in patients with or at risk for Alzheimer’s disease. J Int Neuropsychol Soc10, 200–210.
40.
GolobEJ, IrimajiriR, StarrA (2007) Auditory cortical activity in amnestic mild cognitive impairment: Relationship to subtype and conversion to dementia. Brain130, 740–752.
41.
GreenDL, PayneL, PolikarR, MobergPJ, WolkDA, KouniosJ (2015) P50: A candidate ERP biomarker of prodromal Alzheimer’s disease. Brain Res1624, 390–397.
HoweAS (2013) Meta-analysis of the endogenous N200 latency event-related potential subcomponent in patients with Alzheimer’s disease and mild cognitive impairment. Clin Neurophysiol125, 1145–1151.
44.
HoweAS, Bani-FatemiA, LucaVD (2014) The clinical utility of the auditory P300 latency subcomponent event-related potential in preclinical diagnosis of patients with mild cognitive impairment and Alzheimer’s disease. Brain Cogn86, 64–74.
45.
NieuwenhuisS, YeungN, WildenbergWVD, RidderinkhofKR (2003) Electrophysiological correlates of anterior cingulate function in a go/no-go task: Effects of response conflict and trial type frequency. Cogn Affect Behav Neurosci3, 17–26.
46.
SmithJL, JohnstoneSJ, BarryRJ (2008) Movement-related potentials in the Go/NoGo task: The P3 reflects both cognitive and motor inhibition. Clin Neurophysiol119, 704–714.
McBrideDM, Anne DosherB (2002) A comparison of conscious and automatic memory processes for picture and word stimuli: A process dissociation analysis. Conscious Cogn11, 423–460.
49.
AllyBA, GoldCA, BudsonAE (2009) The picture superiority effect in patients with Alzheimer’s disease and mild cognitive impairment. Neuropsychologia47, 595–598.
50.
AngelL, FayS, BouazzaouiB, BaudouinA, IsingriniM (2010) Protective role of educational level on episodic memory aging: An event-related potential study. Brain Cogn74, 312–323.
51.
AngelL, FayS, BouazzaouiB, GranjonL, IsingriniM (2009) Neural correlates of cued recall in young and older adults: An event-related potential study. Neuroreport20, 75–79.
52.
PolichJ, Corey-BloomJ (2005) Alzheimer’s disease and P300: Review and evaluation of task and modality. Curr Alzheimer Res2, 515–525.
