Abstract
Elucidation of the intricacies of carbohydrate recognition by proteins undoubtedly paves the way for a rational design of carbohydrate-based drugs. Progress towards this goal demands a detailed structural characterisation of the protein target, identification of the ligand determinants essential for recognition and a thorough thermodynamic characterisation of the binding process. To this aim, X-ray crystallography, chemical mapping and calorimetric studies have proved to be highly valuable tools.
Keywords
Get full access to this article
View all access options for this article.