Abstract
In an open Phase-II study on 10 patients with POAD II the plasmatic elimination, rheological and hemostasiological parameters of a new hydroxyethyl starch with a mean molecular weight of 100,0000 Dalton, a molar substitution of 0.5 and a C2/C6 substitution ratio of 6.2 (HES 100/0.5) were determined. Measurements were carried out before and 1, 3, 6, and 24 h after infusion.
The mean molecular weight of 100,000 Dalton decreased only slightly up to 24 hours. The plasmatic molecular distribution width of the HES 100/0.5 was unchanged during the whole period of time - in contrary to other HES-types.
The decrease in the hematocrit of 5.5% is comparable to other HES-types, and is still significant up to 24 h after infusion. Similar effects can be seen for the plasma viscosity. The decrease is about 3% which is still significant 24 h after infusion (from 1.33 mPas to 1.28 mPas after 24 h). The maximal decrease of erythrocyte aggregation is about 26% (from 23 to 18 one hour after infusion), and this effect is still significant 24 h after infusion.
Plasmatic haemostasis is not influenced by hemodilution treatment with HES 100/0.5; prothrombin time and partial thromboplastin time remained unchanged.
The amount of rheological changes is comparable to HES 200/0.5 whilst the improvement of blood fluidity is lasting longer. The lack of influence on plasmatic hemostasis could offer advantages from a hemostasiological point of view.
HES 100/0.5 seems to be an interesting variant of a known and proven colloid which however has to be evaluated in further clinical biometrically stringent studies.
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